Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

Yu, Haitao; Chen, Jia; Wang, Fangzhou; Jia, Dongdong; Bi, Shuguang; Mao, Yuming; Zhang, Yu‐qi; Gao, Tian‐long; Yang, Liu; Du, Jia‐xu; Zhou, Zi‐han; Zhu, Xi‐Chen; Chai, Gao‐shang

doi:10.1002/advs.202502707

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

Autophagy‐lysosomal pathway deficits contribute to the accumulation of amyloid‐β (Aβ), Tau, and lipid droplets in Alzheimer's disease (AD). Capsaicin, a specific agonist of transient receptor potential vanilloid 1 (TRPV1), can improve cognitive function in AD patients, but the detailed mechanism …