Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading

Significance: Neurofibrillary tangles composed of misfolded and aggregated tau protein are degraded by the autophagy–lysosomal pathway. Microglia play a central role in immune surveillance and neuroinflammation. Here, we reveal that microglial autophagy critically controls microglial metabolic an…