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Silicon array of elongated through‐holes for monodisperse emulsion droplets
Abstract
Monodisperse emulsions are of great significance in both scientific and industrial fields, since they have advantages such as their better stability and simplified physical properties. A novel micromachined emulsification device has been developed for monodisperse emulsion droplets. It has uniformly sized through‐holes, called straightthrough microchannel (MC), on a silicon microchip. An oblong straightthrough MC successfully yielded monodisperse oil‐in‐water (O/W) emulsion droplets with an average droplet diameter of 32.5 μm and a coefficient of variation below 2% by forcing the dispersed phase into the continuous phase through the straightthrough MC. On the other hand, a circular straightthrough MC yielded polydisperse emulsion droplets. Straightthrough MC emulsification revealed that an elongated cross‐sectional shape in the oblong straightthrough MC contributes significantly to the spontaneous formation of monodisperse emulsion droplets without any turbulent mixing.
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Cited by
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Zhu, P., & Wang, L. (2017) · Lab on a Chip · doi:10.1039/c6lc01018k · Cited by 1,238
Freitas, S., Merkle, H. P., & Gander, B. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.10.015 · Cited by 923
Okushima, S., Nisisako, T., Torii, T., & Higuchi, T. (2004) · Langmuir · doi:10.1021/la0480336 · Cited by 656
Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery
Zhao, C.-X. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.05.009 · Cited by 451
Industrial lab-on-a-chip: Design, applications and scale-up for drug discovery and delivery
Vladisavljević, G. T., Khalid, N., Neves, M. A., Kuroiwa, T., Nakajima, M., Uemura, K., Ichikawa, S., & Kobayashi, I. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.017 · Cited by 313
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Metadata
- Authors
- Kobayashi, I., Nakajima, M., Chun, K., Kikuchi, Y., & Fujita, H.
- Venue
- AIChE Journal
- Publisher
- Wiley
- Published
- 2002-08
- Volume
- 48
- Issue
- 8
- Pages
- 1639-1644
- ISSN
- 0001-1541 (ISSN-L)
- 1547-5905
- OpenAlex
- W2032752519
- Cited by
- 246
- References
- 0
- FWCI
- 9.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kobayashi, I., Nakajima, M., Chun, K., Kikuchi, Y., & Fujita, H. (2002). Silicon array of elongated through‐holes for monodisperse emulsion droplets. AIChE Journal. https://doi.org/10.1002/aic.690480807
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