The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Iron chelators for the treatment of iron overload disease: Relationship between structure, redox activity, and toxicity
Abstract
The success of the iron (Fe) chelator desferrioxamine (DFO) in the treatment of β‐thalassemia is limited by its lack of bioavailability. The design and characterization of synthetic alternatives to DFO has attracted much scientific interest and has led to the discovery of orally active chelators that can remove pathological Fe deposits. However, chelators that access intracellular Fe pools can be toxic by either inhibiting Fe‐containing enzymes or promoting Fe‐mediated free radical damage. Interestingly, toxicity does not necessarily correlate with Fe‐binding affinity or with chelation efficacy, suggesting that other factors may promote the cytopathic effects of chelators. In this review, we discuss the interactions of chelators and their Fe complexes with biomolecules that can lead to toxicity and tissue damage. Am. J. Hematol. 73:200–210, 2003. © 2003 Wiley‐Liss, Inc.
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Cites
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Cited by
Papanikolaou, G., & Pantopoulos, K. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.06.021 · Cited by 1,070
The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer
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Aldazine-based colorimetric sensors for Cu2+ and Fe3+
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Metadata
- Authors
- Chaston, T. B., & Richardson, D. R.
- Venue
- American Journal of Hematology
- Publisher
- Wiley
- Published
- 2003-06-20
- Volume
- 73
- Issue
- 3
- Pages
- 200-210
- ISSN
- 0361-8609 (ISSN-L)
- 1096-8652
- OpenAlex
- W1979703805
- Cited by
- 168
- References
- 15
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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