Iron metabolism and toxicity

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535 · see citing works

[1] Role of free radicals and catalytic metal ions in human disease: An overview

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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · cited 1× · see citing works

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333 · see citing works

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166 · see citing works

The ferritins: molecular properties, iron storage function and cellular regulation

Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667 · see citing works

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · cited 2× · see citing works

A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549 · see citing works

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168 · see citing works

Disorders of Iron Metabolism

Andrews, N. C. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912233412607 · Cited by 2,130 · see citing works

Iron-sulfur clusters: nature's modular, multipurpose structures

Beinert, H., Holm, R. H., & Münck, E. (1997) · Science · doi:10.1126/science.277.5326.653 · Cited by 1,944 · see citing works

Balancing Acts

Hentze, M. W., Muckenthaler, M. U., & Andrews, N. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00343-5 · Cited by 1,736 · see citing works

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667 · see citing works

Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1998) · Blood · doi:10.1182/blood.v92.9.3007.421k47_3007_3017 · Cited by 1,640 · see citing works

Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation

Ganz, T. (2003) · Blood · doi:10.1182/blood-2003-03-0672 · Cited by 1,544 · see citing works

A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422 · see citing works

The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition

Goetz, D. H., Holmes, M. A., Borregaard, N., Bluhm, M. E., Raymond, K. N., & Strong, R. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00708-6 · Cited by 1,355 · see citing works

LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

Krause, A., Neitz, S., Mägert, H.-J., Schulz, A., Forssmann, W.-G., Schulz-Knappe, P., & Adermann, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01920-7 · Cited by 1,324 · see citing works

A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism

Abboud, S., & Haile, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000713200 · Cited by 1,267 · see citing works

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( <i>USF2</i> ) knockout mice

Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., & Vaulont, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151179498 · Cited by 1,233 · see citing works

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214 · see citing works

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., & Andrews, N. C. (1997) · Nature Genetics · doi:10.1038/ng0897-383 · Cited by 1,159 · see citing works

An iron-regulated ferric reductase associated with the absorption of dietary iron

McKie, A. T., Barrow, D., Latunde-Dada, G. O., Rolfs, A., Sager, G., Mudaly, E., Mudaly, M., Richardson, C., Barlow, D., Bomford, A., et al. (2001) · Science · doi:10.1126/science.1057206 · Cited by 1,101 · see citing works

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

Vulpe, C. D., Kuo, Y.-M., Murphy, T. L., Cowley, L., Askwith, C., Libina, N., Gitschier, J., & Anderson, G. J. (1999) · Nature Genetics · doi:10.1038/5979 · Cited by 1,084 · see citing works

Hereditary Hemochromatosis — A New Look at an Old Disease

Pietrangelo, A. (2004) · New England Journal of Medicine · doi:10.1056/nejmra031573 · Cited by 992 · see citing works

Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

Papanikolaou, G., Samuels, M. E., Ludwig, E. H., MacDonald, M. L. E., Franchini, P. L., Dubé, M.-P., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1274 · Cited by 974 · see citing works

C ERULOPLASMIN M ETABOLISM AND F UNCTION

Hellman, N. E., & Gitlin, J. D. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.012502.114457 · Cited by 930 · see citing works

Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont, C., Grandchamp, B., Sirito, M., Sawadogo, M., Kahn, A., & Vaulont, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072632499 · Cited by 880 · see citing works

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

Roetto, A., Papanikolaou, G., Politou, M., Alberti, F., Girelli, D., Christakis, J., Loukopoulos, D., & Camaschella, C. (2003) · Nature Genetics · doi:10.1038/ng1053 · Cited by 860 · see citing works

The labile iron pool: characterization, measurement, and participation in cellular processes1 1This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal.

Kakhlon, O., & Cabantchik, Z. I. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01006-7 · Cited by 839 · see citing works

Penetrance of 845G→A (C282Y) HFE hereditary haemochromatosis mutation in the USA

Beutler, E., Felitti, V. J., Koziol, J. A., Ho, N. J., & Gelbart, T. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07447-0 · Cited by 823 · see citing works

The heme synthesis and degradation pathways: role in oxidant sensitivity

Ryter, S. W., & Tyrrell, R. M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00223-3 · Cited by 822 · see citing works

Chemistry and biology of eukaryotic iron metabolism

Aisen, P. (2001) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/s1357-2725(01)00063-2 · Cited by 804 · see citing works

The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22

Camaschella, C., Roetto, A., Calì, A., De Gobbi, M., Garozzo, G., Carella, M., Majorano, N., Totaro, A., & Gasparini, P. (2000) · Nature Genetics · doi:10.1038/75534 · Cited by 803 · see citing works

Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?

Ischiropoulos, H., & Beckman, J. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317638 · Cited by 748 · see citing works

An Iron Delivery Pathway Mediated by a Lipocalin

Yang, J., Goetz, D., Li, J.-Y., Wang, W., Mori, K., Setlik, D., Du, T., Erdjument-Bromage, H., Tempst, P., Strong, R., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00710-4 · Cited by 651 · see citing works

Molecular Cloning of Transferrin Receptor 2

Kawabata, H., Yang, R., Hirama, T., Vuong, P. T., Kawano, S., Gombart, A. F., & Koeffler, H. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.20826 · Cited by 646 · see citing works

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis

Bridle, K. R., Frazer, D. M., Wilkins, S. J., Dixon, J. L., Purdie, D. M., Crawford, D. H., Subramaniam, V. N., Powell, L. W., Anderson, G. J., & Ramm, G. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12602-5 · Cited by 620 · see citing works

ROS, stress‐activated kinases and stress signaling in cancer

Benhar, M., Engelberg, D., & Levitzki, A. (2002) · The EMBO Reports · doi:10.1093/embo-reports/kvf094 · Cited by 600 · see citing works

Transferrin receptor is necessary for development of erythrocytes and the nervous system

Levy, J. E., Jin, O., Fujiwara, Y., Kuo, F., & Andrews, N. (1999) · Nature Genetics · doi:10.1038/7727 · Cited by 574 · see citing works

Structure of the human transferrin receptor-transferrin complex

Cheng, Y., Zak, O., Aisen, P., Harrison, S. C., & Walz, T. (2004) · Cell · doi:10.1016/s0092-8674(04)00130-8 · Cited by 571 · see citing works

Iron-induced carcinogenesis: The role of redox regulation

Toyokuni, S. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02111-6 · Cited by 562 · see citing works

Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene

Montosi, G., Donovan, A., Totaro, A., Garuti, C., Pignatti, E., Cassanelli, S., Trenor, C. C., Gasparini, P., Andrews, N. C., & Pietrangelo, A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113468 · Cited by 557 · see citing works

Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene

Montosi, G., Donovan, A., Totaro, A., Garuti, C., Pignatti, E., Cassanelli, S., Trenor, C. C., Gasparini, P., Andrews, N. C., & Pietrangelo, A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13468 · Cited by 555 · see citing works

Tissue-Specific Regulation of Iron Metabolism and Heme Synthesis: Distinct Control Mechanisms in Erythroid Cells

Ponka, P. (1997) · Blood · doi:10.1182/blood.v89.1.1 · Cited by 544 · see citing works

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease

Curtis, A. R. J., Fey, C., Morris, C. M., Bindoff, L. A., Ince, P. G., Chinnery, P. F., Coulthard, A., Jackson, M. J., Jackson, A. P., McHale, D. P., et al. (2001) · Nature Genetics · doi:10.1038/ng571 · Cited by 537 · see citing works

Function and regulation of transferrin and ferritin.

Ponka, P., Beaumont, C., & Richardson, D. R. (1998) · PubMed · Cited by 524 · see citing works

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

LaVaute, T., Smith, S., Cooperman, S., Iwai, K., Land, W., Meyron-Holtz, E., Drake, S. K., Miller, G., Abu-Asab, M., Tsokos, M., et al. (2001) · Nature Genetics · doi:10.1038/84859 · Cited by 509 · see citing works

Iron Metabolism and the IRE/IRP Regulatory System: An Update

Pantopoulos, K. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.001 · Cited by 505 · see citing works

A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis

Njajou, O. T., Vaessen, N., Joosse, M., Berghuis, B., van Dongen, J. W. F., Breuning, M. H., Snijders, P. J. L. M., Rutten, W. P. F., Sandkuijl, L. A., Oostra, B. A., et al. (2001) · Nature Genetics · doi:10.1038/90038 · Cited by 492 · see citing works

A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans

Yoshida, K., Furihata, K., Takeda, S., Nakamura, A., Yamamoto, K., Morita, H., Hiyamuta, S., Ikeda, S.-I., Shimizu, N., & Yanagisawa, N. (1995) · Nature Genetics · doi:10.1038/ng0395-267 · Cited by 463 · see citing works

Regulators of iron balance in humans [see comments]

Finch, C. (1994) · Blood · doi:10.1182/blood.v84.6.1697.1697 · Cited by 455 · see citing works

Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal

Huang, X. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.023 · Cited by 444 · see citing works

Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factorPreprint

Bruick, R. K. (2003) · Genes & Development · doi:10.1101/gad.1145503 · Cited by 435 · see citing works

Iron homeostasis: insights from genetics and animal models

Andrews, N. C. (2000) · Nature Reviews Genetics · doi:10.1038/35042073 · Cited by 418 · see citing works

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.

Meyron‐Holtz, E. G., Ghosh, M. C., Iwai, K., LaVaute, T., Brazzolotto, X., Berger, U. V., Land, W., Ollivierre‐Wilson, H., Grinberg, A., Love, P., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600041 · Cited by 408 · see citing works

Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system

Jeong, S. Y., & David, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301988200 · Cited by 377 · see citing works

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

Muckenthaler, M. U., Roy, C. N., Custodio, Á. O., Miñana, B., DEGRAAF, J., Montross, L. K., Andrews, N. C., & Hentze, M. W. (2003) · Nature Genetics · doi:10.1038/ng1152 · Cited by 293 · see citing works

Pathogenesis and treatment of anaemia of chronic disease

Weiß, G. (2002) · Blood Reviews · doi:10.1054/blre.2002.0193 · Cited by 276 · see citing works

Decreased Liver Hepcidin Expression in the Hfe Knockout Mouse

Ahmad, K. A., Ahmann, J. R., Migas, M. C., Waheed, A., Britton, R. S., Bacon, B. R., Sly, W. S., & Fleming, R. E. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0575 · Cited by 276 · see citing works

Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis

Merryweather‐Clarke, A. T. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg225 · Cited by 262 · see citing works

Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: Oxyradical overload diseases

Hussain, S. P., Raja, K., Amstad, P., Sawyer, M., Trudel, L. J., Wogan, G. N., Hofseth, L. J., Shields, P. G., Billiar, T. R., Trautwein, C., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220416097 · Cited by 248 · see citing works

Secondary Iron Overload

Kushner, J. P., Porter, J. B., & Olivieri, N. F. (2001) · Hematology · doi:10.1182/asheducation-2001.1.47 · Cited by 246 · see citing works

Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron

Gehrke, S. G., Kulaksiz, H., Herrmann, T. R. W., Riedel, H.-D., Bents, K., Veltkamp, C., & Stremmel, W. (2003) · Blood · doi:10.1182/blood-2002-11-3610 · Cited by 244 · see citing works

Juvenile Hemochromatosis Locus Maps to Chromosome 1q

Roetto, A., Totaro, A., Cazzola, M., Cicilano, M., Bosio, S., D’Ascola, D. G., Carella, M., Zelante, L., Kelly, A., Cox, T. M., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302379 · Cited by 235 · see citing works

The Chelatable Iron Pool in Living Cells: A Methodically Defined Quantity

Petrat, F. M., de GROOT, H., Sustmann, R., & Rauen, U. (2002) · Biological Chemistry · doi:10.1515/bc.2002.051 · Cited by 230 · see citing works

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2

Iwai, K., Klausner, R. D., & Rouault, T. A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00219.x · Cited by 211 · see citing works

H-ferritin subunit overexpression in erythroid cells reduces the oxidative stress response and induces multidrug resistance properties

Epsztejn, S., Glickstein, H., Picard, V., Slotki, I. N., Breuer, W., Beaumont, C., & Cabantchik, Z. I. (1999) · Blood · doi:10.1182/blood.v94.10.3593.422k26_3593_3603 · Cited by 209 · see citing works

Iron and carcinogenesis: from Fenton reaction to target genes

Toyokuni, S. (2002) · Redox Report · doi:10.1179/135100002125000596 · Cited by 203 · see citing works

Nitric Oxide and Oxidative Stress (H₂O₂) Control Mammalian Iron Metabolism by Different Pathways

Pantopoulos, K., Weiss, G., & Hentze, M. W. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3781 · Cited by 195 · see citing works

A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption

Frazer, D. M. (2003) · Gut · doi:10.1136/gut.52.3.340 · Cited by 189 · see citing works

Identification of the ubiquitin–protein ligase that recognizes oxidized IRP2

Yamanaka, K., Ishikawa, H., Megumi, Y., Tokunaga, F., Kanie, M., Rouault, T. A., Morishima, I., Minato, N., Ishimori, K., & Iwai, K. (2003) · Nature Cell Biology · doi:10.1038/ncb952 · Cited by 181 · see citing works

Iron homeostasis: new tales from the crypt

Roy, C. N., & Enns, C. A. (2000) · Blood · doi:10.1182/blood.v96.13.4020 · Cited by 175 · see citing works

Mechanisms of Iron Accumulation in Hereditary Hemochromatosis

Fleming, R. E., & Sly, W. S. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.155838 · Cited by 172 · see citing works

Metals, Oxidative Stress, and Hepatic Fibrogenesis

Pietrangelo, A. (1996) · Seminars in Liver Disease · doi:10.1055/s-2007-1007215 · Cited by 170 · see citing works

Iron chelators for the treatment of iron overload disease: Relationship between structure, redox activity, and toxicity

Chaston, T. B., & Richardson, D. R. (2003) · American Journal of Hematology · doi:10.1002/ajh.10348 · Cited by 168 · see citing works

HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype

Jacolot, S., Gac, G. L., Scotet, V., Quéré, I., Mura, C., & Férec, C. (2003) · Blood · doi:10.1182/blood-2003-10-3366 · Cited by 164 · see citing works

Molecular and Cellular Iron Transport

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Iron and hepatocellular carcinoma

Deugnier, Y., & Turlin, B. (2001) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2001.02430.x · Cited by 145 · see citing works

Oxygen and Iron Regulation of Iron Regulatory Protein 2

Hanson, E. S., Rawlins, M. L., & Leibold, E. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302798200 · Cited by 140 · see citing works

Activation of iron regulatory protein-1 by oxidative stress in vitro

Pantopoulos, K., & Hentze, M. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10559 · Cited by 129 · see citing works

Non- HFE hemochromatosis

Pietrangelo, A. (2004) · Hepatology · doi:10.1002/hep.20007 · Cited by 127 · see citing works

An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice

Roy, C. N., Custodio, Á. O., de Graaf, J., Schneider, S., Akpan, I. J., Montross, L. K., Sánchez, M., Gaudino, A., Hentze, M. W., Andrews, N. C., et al. (2004) · Nature Genetics · doi:10.1038/ng1350 · Cited by 120 · see citing works

High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats

Tanaka, T. U., Iwasa, Y., Kondo, S., Hiai, H., & Toyokuni, S. (1999) · Oncogene · doi:10.1038/sj.onc.1202707 · Cited by 117 · see citing works

Iron-Mediated Degradation of IRP2, an Unexpected Pathway Involving a 2-Oxoglutarate-Dependent Oxygenase Activity

Wang, J., Chen, G., Muckenthaler, M. U., Galy, B., Hentze, M. W., & Pantopoulos, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.954-965.2004 · Cited by 116 · see citing works

Decreased hepcidin mRNA expression in thalassemic mice

Adamsky, K., Weizer, O., Amariglio, N., Breda, L., Harmelin, A., Rivella, S., Rachmilewitz, E., & Rechavi, G. (2004) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04734.x · Cited by 108 · cited 1× · see citing works

Myeloperoxidase-derived Hypochlorous Acid Antagonizes the Oxidative Stress-mediated Activation of Iron Regulatory Protein 1

Mütze, S., Hebling, U., Stremmel, W., Wang, J., Arnhold, J., Pantopoulos, K., & Mueller, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307159200 · Cited by 101 · see citing works

Hereditary Causes of Disturbed Iron Homeostasis in the Central Nervous System

Ponka, P. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.022 · Cited by 99 · see citing works

Repression of ferritin expression increases the labile iron pool, oxidative stress, and short-term growth of human erythroleukemia cells

Kakhlon, O., Gruenbaum, Y., & Cabantchik, Z. I. (2001) · Blood · doi:10.1182/blood.v97.9.2863 · Cited by 97 · see citing works

S-Nitrosylation of IRP2 Regulates Its Stability via the Ubiquitin-Proteasome Pathway

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