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Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors
Open accessAbstract
The new oral anticoagulants dabigatran, rivaroxaban and apixaban have advantages over warfarin which include no need for laboratory monitoring, less drug–drug interactions and less food‐drug interactions. However, there is no established antidote for patients who are bleeding or require emergent surgery and there is a paucity of evidence to guide the clinical care during these situations. Members of thrombosis and anticoagulation groups participating in the Thrombosis and Hemostasis Summit of North America formulated expert opinion guidance for reversing the anticoagulant effect of the new oral anticoagulants and suggest: routine supportive care, activated charcoal if drug ingestion was within a couple of hours, and hemodialysis if feasible for dabigatran. Also, the pros and cons of the possible use of four factor prothrombin complex concentrate are discussed. Am. J. Hematol. 2012. © 2012 Wiley Periodicals, Inc.
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Kearon (2012) · doi:10.1378/chest.11-2301 · Cited by 6,119
Cited by
Meschia, J. F., Bushnell, C., Boden-Albala, B., Braun, L. T., Bravata, D. M., Chaturvedi, S., Creager, M. A., Eckel, R. H., Elkind, M. S. V., Fornage, M., et al. (2014) · Stroke · doi:10.1161/str.0000000000000046 · Cited by 2,650
Smith, E. E., Saposnik, G., Biessels, G. J., Doubal, F. N., Fornage, M., Gorelick, P. B., Greenberg, S. M., Higashida, R. T., Kasner, S. E., & Seshadri, S. (2017) · Stroke · doi:10.1161/str.0000000000000116 · Cited by 404
Management of acute stroke in patients taking novel oral anticoagulants
Hankey, G. J., Norrving, B., Hacke, W., & Steiner, T. (2014) · International Journal of Stroke · doi:10.1111/ijs.12295 · Cited by 63
Walsh, M., Fritz, S., Hake, D., Son, M., Greve, S., Jbara, M., Chitta, S., Fritz, B., Miller, A., K Bader, M., et al. (2016) · Current Drug Targets · doi:10.2174/1389450117666160310153211 · Cited by 58
Metadata
- Authors
- Kaatz, S., Kouides, P. A., Garcia, D. A., Spyropolous, A. C., Crowther, M., Douketis, J. D., Chan, A. K. C., James, A., Moll, S., Ortel, T. L., Van Cott, E. M., & Ansell, J.
- Venue
- American Journal of Hematology
- Publisher
- Wiley
- Published
- 2012-04-04
- Volume
- 87
- Issue
- S1
- Pages
- S141-5
- ISSN
- 0361-8609 (ISSN-L)
- 1096-8652
- OpenAlex
- W2046186673
- Cited by
- 365
- References
- 1
- FWCI
- 45.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kaatz, S., Kouides, P. A., Garcia, D. A., Spyropolous, A. C., Crowther, M., Douketis, J. D., Chan, A. K. C., James, A., Moll, S., Ortel, T. L., Van Cott, E. M., & Ansell, J. (2012). Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. American Journal of Hematology. https://doi.org/10.1002/ajh.23202
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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