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Potential occupational risks for neurodegenerative diseases
Abstract
BACKGROUND: Associations between occupations and neurodegenerative diseases (NDD) may be discernable in death certificate data. METHODS: Hypotheses generated from 1982 to 1991 study were tested in data from 22 states for the years 1992-1998. Specific occupations and exposures to pesticides, solvents, oxidative stressors, magnetic fields, and welding fumes were evaluated. RESULTS: About one third (26/87) of the occupations hypothesized with neurodegenerative associations had statistically significant elevated mortality odds ratios (MOR) for the same outcome. Occupations with the largest MORs were (a) for presenile dementia (PSD)-dentists, graders/sorters (non-agricultural), and clergy; (b) for Alzheimer's disease (AD)-bank tellers, clergy, aircraft mechanics, and hairdressers; (c) for Parkinson's disease (PD)-biological scientists, clergy, religious workers, and post-secondary teachers; and (d) for motor neuron disease (MND)-veterinarians, hairdressers, and graders and sorters (non-agricultural). Teachers had significantly elevated MORs for all four diseases, and hairdressers for three of the four. Non-horticultural farmers below age 65 had elevated PD (MOR = 2.23, 95% CI = 1.47-3.26), PSD (MOR = 2.22, 95% CI = 1.10-4.05), and AD (MOR = 1.76, 95% CI = 1.04-2.81). Sixty hertz magnetic fields exhibited significant exposure-response for AD and, below age 65, for PD (MOR = 1.87, 95% CI = 1.14-2.98) and MND (MOR = 1.63, 95% CI = 1.10-2.39). Welding had elevated PD mortality below age 65 (MOR = 1.77, 95% CI = 1.08-2.75). CONCLUSIONS: Support was observed for hypothesized excess neurodegenerative disease associated with a variety of occupations, 60 Hz magnetic fields and welding.
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“Of the 14 studies with the highest quality ratings, eight (57%) reported positive relationships [423–430] and three (21%) reported negative relationships with cognitive function [431–433].”
From Religion, Spirituality, and Health: The Research and Clinical Implications (2012) · cites this paper as [423]
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Metadata
- Authors
- Park, R. M., Schulte, P. A., Bowman, J. D., Walker, J. T., Bondy, S. C., Yost, M. G., Touchstone, J. A., & Dosemeci, M.
- Affiliations
- National Institute for Occupational Safety and Health (US)
- University of California, Irvine (US)
- University of Washington (US)
- Division of Cancer Epidemiology and Genetics (US)
- Corresponding author
- Park, Robert M.
- Venue
- American Journal of Industrial Medicine
- Publisher
- Wiley
- Published
- 2005
- Volume
- 48
- Issue
- 1
- Pages
- 63-77
- ISSN
- 0271-3586 (ISSN-L)
- 1097-0274
- OpenAlex
- W2135848716
- Cited by
- 256
- References
- 93
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 48 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 9 · 2018: 10 · 2017: 10 · 2016: 13 · 2015: 12 · 2014: 18 · 2013: 16 · 2012: 16
- FWCI
- 31.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Industrial Medicine (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational Health and Safety in Workplaces
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Keywords
- neurodegenerative diseases, occupational exposure, occupational mortality, Alzheimer's disease, Parkinson's disease, motor neuron disease, early-onset dementia, pesticides, solvents, oxidative stress, 60 Hz magnetic fields, welding fumes, dentists, hairdressers, farmers, teachers, clergy
- MeSH terms
- Adult, Aged, Aged, 80 and over, Death Certificates, Electromagnetic Fields, Female, Humans, Male, Middle Aged, Occupational Diseases, Occupations, Risk Factors, United States, Epidemiologic Studies, Occupational Exposure, Risk Assessment, Neurodegenerative Diseases
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