Cited by 333Cholinesterase and Neurodegenerative DiseasesMedicinal Plants and NeuroprotectionPhytochemicals and Antioxidant Activities

Comparative study on the inhibitory effect of caffeic and chlorogenic acids on key enzymes linked to Alzheimer’s disease and some pro-oxidant induced oxidative stress in rats’ brain-in vitro

Oboh, Ganiyu, Agunloye, Odunayo M., Akinyemi, Ayodele J., Ademiluyi, Adedayo O., Adefegha, Stephen A.·2013·Neurochemical Research

Abstract

This study sought to investigate and compare the interaction of caffeic acid and chlorogenic acid on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and some pro-oxidants (FeSO(4), sodium nitroprusside and quinolinic acid) induced oxidative stress in rat brain in vitro. The result revealed that caffeic acid and chlorogenic acid inhibited AChE and BChE activities in dose-dependent manner; however, caffeic acid had a higher inhibitory effect on AChE and BChE activities than chlorogenic acid. Combination of the phenolic acids inhibited AChE and BChE activities antagonistically. Furthermore, pro-oxidants such as, FeSO(4), sodium nitroprusside and quinolinic acid caused increase in the malondialdehyde (MDA) contents of the brain which was significantly decreased dose-dependently by the phenolic acids. Inhibition of AChE and BChE activities slows down acetylcholine and butyrylcholine breakdown in the brain. Therefore, one possible mechanism through which the phenolic acids exert their neuroprotective properties is by inhibiting AChE and BChE activities as well as preventing oxidative stress-induced neurodegeneration. However, esterification of caffeic acid with quinic acid producing chlorogenic acid affects these neuroprotective properties.

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Crossref · 10.1007/s11064-012-0935-6

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Authors
Oboh, G., Agunloye, O. M., Akinyemi, A. J., Ademiluyi, A. O., & Adefegha, S. A.
Affiliations
Federal University of Technology (NG)
Corresponding author
  • Oboh, Ganiyu
  • Akinyemi, Ayodele J.
Venue
Neurochemical Research
Published
2012-11-27
Volume
38
Issue
2
Pages
413-419
ISSN
  • 0364-3190 (ISSN-L)
  • 1573-6903
OpenAlex
W1973733191
Cited by
333
References
42
Citations by year
2026: 12 · 2025: 19 · 2024: 38 · 2023: 39 · 2022: 43 · 2021: 32 · 2020: 37 · 2019: 19 · 2018: 20 · 2017: 25 · 2016: 21 · 2015: 17 · 2014: 7 · 2013: 4
FWCI
6.57
Type
journal article
Language
en
Open access
closed
Locations
  • Neurochemical Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
caffeic acid, chlorogenic acid, phenolic acids, acetylcholinesterase inhibition, butyrylcholinesterase inhibition, Alzheimer's disease, oxidative stress, pro-oxidants, malondialdehyde, neuroprotection, quinolinic acid, sodium nitroprusside, iron sulfate, brain
MeSH terms
Acetylcholinesterase, Alzheimer Disease, Animals, Brain, Butyrylcholinesterase, Caffeic Acids, Chlorogenic Acid, Cholinesterase Inhibitors, Male, Rats, Wistar, Reactive Oxygen Species, Oxidative Stress, Rats

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