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Cited by 83Bipolar Disorder and TreatmentGenetic Associations and EpidemiologySchizophrenia research and treatment

Different familial transmission patterns in bipolar I disorder with onset before and after age 25

Grigoroiu‐Serbanescu, Maria, Martinez, Maria, Nöthen, Markus M., Grinberg, Mihaela, Sima, Dorina, Propping, Peter, Marinescu, Elvira, Hrestic, Mihaela·2001·American Journal of Medical Genetics
DOI 10.1002/ajmg.10047
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Abstract

Gene identification in common disorders such as Alzheimer disease and breast cancer has greatly profited from the use of age of onset as criterion to delineate subgroups of disease characterized by different inheritance patterns. In bipolar affective disorder, where the majority of linkage studies have produced conflicting results, studies reporting clinical characteristics and familial occurrence of disease have suggested that age of onset might serve as an indicator for identifying more homogeneous subgroups of disease. Our study was the first to examine this hypothesis by the means of segregation analysis. We investigated a sample of 177 bipolar I probands recruited from consecutive admissions and their first‐ and second‐degree relatives (2,407 subjects). Probands were subdivided into an early‐onset (n = 107) and a late‐onset group (n = 70) using an age of onset of 25 as a cut‐off point. This age was chosen because the observed age of onset distribution was bimodal with a cut‐off of 25 years. Morbid risks for affective disorder were found significantly higher (P = 0.01) in relatives of probands with an early onset than in probands with late onset of disease. The segregation analysis showed that the disease is transmitted differently in early‐ and late‐onset groups. In the early‐onset group, a non‐Mendelian major gene with a polygenic component was favored while the data in the late‐onset group were compatible with a multifactorial model. This result may have important implications for future molecular studies aiming at the identification of disease‐associated genes. © 2001 Wiley‐Liss, Inc.

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  • A prior study found that familial segregation of early-onset bipolar disorder was consistent with major gene effects, while late-onset segregation was consistent with multifactorial etiology.

    “Also consistent with this notion, a previous study found that segregation of early-onset bipolar disorder in families was consistent with major gene effects, whereas familial segregation of late-onset bipolar disorder was consistent with a multifactorial etiology (Grigoroiu-Serbanescu et al., 2001).”

    From CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics (2012) · cites this paper as Grigoroiu-Serbanescu et al., 2001

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Authors
Grigoroiu‐Serbanescu, M., Martinez, M., Nöthen, M. M., Grinberg, M., Sima, D., Propping, P., Marinescu, E., & Hrestic, M.
Affiliations
  • Inserm (FR)
  • University of Bonn (DE)
  • Spitalul Clinic de Psihiatrie Alexandru Obregia (RO)
ORCID
Venue
American Journal of Medical Genetics
Publisher
Wiley
Published
2001-11-07
Volume
105
Issue
8
Pages
765-773
ISSN
  • 0148-7299 (ISSN-L)
  • 1096-8628
DOI
10.1002/ajmg.10047
OpenAlex
W2059297404
Cited by
83
References
39
Citations by year
2024: 4 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 5
FWCI
3.01
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • American Journal of Medical Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
The Romanian National Agency for Research and the Deutsche Akademische Austauschdienst (DAAD)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
bipolar I disorder, age of onset, family transmission, segregation analysis, early-onset bipolar disorder, late-onset bipolar disorder, non-Mendelian inheritance, polygenic inheritance, multifactorial inheritance, genetic heterogeneity
MeSH terms
Adult, Bipolar Disorder, Family, Family Health, Female, Humans, Male, Middle Aged, Models, Genetic, Risk Factors, Age of Onset, Genetic Heterogeneity

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