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Cited by 297Bipolar Disorder and TreatmentSchizophrenia research and treatmentPersonality Disorders and Psychopathology

Early and late onset bipolar disorders: two different forms of manic-depressive illness?

Schürhoff, Franck, Bellivier, Frank, Jouvent, Roland, Mouren-Siméoni, Marie-Christine, Bouvard, Manuel, Allilaire, Jean-François, Leboyer, Marion·2000·Journal of Affective Disorders
DOI 10.1016/s0165-0327(99)00111-1
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Abstract

Background Conflicting results in genetic studies of bipolar disorders may be due to the clinical and genetic heterogeneity of the disease. Age at onset of bipolar disorders may be a key indicator for identifying more homogeneous clinical subtypes. We tested whether early onset and late onset bipolar illness represent two different forms of bipolar illness in terms of clinical features, comorbidity and familial risk.Methods Among a consecutively recruited sample of 210 bipolar patients, we compared early onset (n=58) and late onset (n=39) bipolar patients; the cut-off points were age at onset before 18 years and after 40 years for the two subgroups. The subgroups were compared by independent t tests and a contingency table by raw chi-square test. Morbid risk among first-degree relatives was measured by the survival analysis method.Results The early onset group had the most severe form of bipolar disorder with more psychotic features (P=0.03), more mixed episodes (P=0.01), greater comorbidity with panic disorder (P=0.01) and poorer prophylactic lithium response (P=0.04). First degree relatives of early onset patients also had a higher risk of affective disorders (P=0.0002), and exhibit the more severe phenotype, i.e bipolar disorder.Conclusion Our data suggest that early and late onset bipolar disorders differ in clinical expression and familial risk and may therefore be considered to be different subforms of manic-depressive illness.

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  • Schizophrenia and bipolar disorder have low prevalence in younger individuals and heterogeneous symptoms in late-onset.

    “Only patients aged 15 to 60 years were included due to the low prevalence of schizophrenia and bipolar disorder in younger individuals (eFigure 1 in Supplement 1) and heterogeneous symptoms in late-onset schizophrenia and bipolar disorder.”

    From Predicting Diagnostic Progression to Schizophrenia or Bipolar Disorder via Machine Learning (2025) · cites this paper as [20]

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Authors
Schürhoff, F., Bellivier, F., Jouvent, R., Mouren-Siméoni, M.-C., Bouvard, M., Allilaire, J.-F., & Leboyer, M.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Inserm (FR)
  • Pitié-Salpêtrière Hospital (FR)
Corresponding author
Schürhoff, Franck
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2000-06
Volume
58
Issue
3
Pages
215-221
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/s0165-0327(99)00111-1
OpenAlex
W2012850580
Cited by
297
References
26
Citations by year
2026: 3 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 7 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 13 · 2016: 7 · 2015: 19 · 2014: 14 · 2013: 14 · 2012: 12
FWCI
7.69
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords
bipolar disorder, early-onset bipolar disorder, late-onset bipolar disorder, age of onset, clinical subtypes, familial risk, first-degree relatives, comorbidities, panic disorder, mixed states, psychotic features, lithium prophylaxis, genetic heterogeneity
MeSH terms
Adolescent, Adult, Aged, Bipolar Disorder, Child, Female, Humans, Male, Middle Aged, Pedigree, Phenotype, Risk Factors, Severity of Illness Index, Comorbidity, Panic Disorder, Age of Onset

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