The DOI matches its Crossref record.
Multiple sclerosis. Updated risks for relatives
Abstract
Two important characteristics of multiple sclerosis (MS) are familial clustering and a variable age of onset. There is increasing evidence for a genetically influenced susceptibility in MS. Because of this, patients and their relatives are increasingly asking about the risk for relatives of developing MS. In the MS Clinic in Vancouver, genetic histories are taken routinely for all patients and are updated annually. Patients do not attend the clinic specifically to participate in genetic studies, which could result in over‐representation of familial cases. Data were available for 815 MS index cases and 11,345 of their relatives. Age‐specific MS risks were calculated for first‐, second‐, and third‐degree relatives of probands and are presented in an easy‐reference format. In general, first‐degree relatives of probands have a risk that is 30–50 times greater than the 0.1% risk for the general population.
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Citations
Cited by
The natural history of multiple sclerosis:a geographically based study
Cottrell, D. A., Kremenchutzky, M., Rice, G. P. A., Koopman, W. J., Hader, W., Baskerville, J., & Ebers, G. C. (1999) · Brain · doi:10.1093/brain/122.4.625 · Cited by 1,163
Genetics of multiple sclerosis
Dyment, D. A., Ebers, G. C., & Dessa Sadovnick, A. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00663-x · Cited by 563
Multiple sclerosis: risk factors, prodromes, and potential causal pathways
Ramagopalan, S. V., Dobson, R., Meier, U. C., & Giovannoni, G. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70094-6 · Cited by 548
Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis
Martin, R., McFarland, H. F., & Boggs, J. M. (1995) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369509084683 · Cited by 376
Evidence for genetic basis of multiple sclerosis
Sadovnick, A. D., the Canadian Collaborative Study Group, Dyment, D. A., Ebers, G. C., & Risch, N. J. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90807-7 · Cited by 351
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Metadata
- Authors
- Sadovnick, A. D., Baird, P. A., Ward, R. H., Optiz, J. M., & Reynolds, J. F.
- Venue
- American Journal of Medical Genetics
- Publisher
- Wiley
- Published
- 1988-03
- Volume
- 29
- Issue
- 3
- Pages
- 533-541
- ISSN
- 0148-7299 (ISSN-L)
- 1096-8628
- OpenAlex
- W2171939038
- Cited by
- 315
- References
- 0
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sadovnick, A. D., Baird, P. A., Ward, R. H., Optiz, J. M., & Reynolds, J. F. (1988). Multiple sclerosis. Updated risks for relatives. American Journal of Medical Genetics. https://doi.org/10.1002/ajmg.1320290310
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
