Cited by 548Multiple Sclerosis Research StudiesPsoriasis: Treatment and PathogenesisPolyomavirus and related diseases

Multiple sclerosis: risk factors, prodromes, and potential causal pathways

Ramagopalan, Sreeram V, Dobson, Ruth, Meier, Ute C, Giovannoni, Gavin·2010·The Lancet Neurology

Abstract

Multiple sclerosis (MS) is a common, complex neurological disease. The precise aetiology of MS is not yet known, although epidemiological data indicate that both genetic and environmental factors are important. The evidence that the environment acts long before MS becomes clinically evident is well established and suggests the existence of a prodromal phase for the disease. The increasing incidence of MS emphasises the need for strategies to prevent this chronic disorder, and the possibility of a prodrome indicates a window of opportunity to potentially reverse early disease processes before clinical disease becomes evident. Studying a prodrome requires techniques other than clinical observation such as monitoring endophenotypes that result from associated risk factors. However, our current knowledge of causal pathways and endophenotypes in MS is limited. Identifying and studying individuals with a high risk of developing the disease provides a powerful opportunity to understand the MS causal cascade and is highly relevant to strategies that are aimed at preventing this debilitating disease.

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Crossref · 10.1016/s1474-4422(10)70094-6

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  • Mutations in various SYK-related molecules have been identified as prominent MS genetic risk factors.

    “This is surprising given that mutations in various SYK-related molecules have been identified as prominent MS genetic risk factors (Ramagopalan et al., 2010).”

    From SYK coordinates neuroprotective microglial responses in neurodegenerative disease (2022) · cites this paper as Ramagopalan et al., 2010

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Authors
Ramagopalan, S. V., Dobson, R., Meier, U. C., & Giovannoni, G.
Affiliations
  • Centre for Human Genetics (GB)
  • Queen Mary University of London (GB)
Corresponding author
Giovannoni, Gavin
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2010-07
Volume
9
Issue
7
Pages
727-739
ISSN
1474-4422 (ISSN-L)
OpenAlex
W2149134458
Cited by
548
References
155
Citations by year
2026: 18 · 2025: 25 · 2024: 19 · 2023: 33 · 2022: 38 · 2021: 33 · 2020: 32 · 2019: 36 · 2018: 24 · 2017: 39 · 2016: 39 · 2015: 31 · 2014: 38 · 2013: 41 · 2012: 49
FWCI
5.57
Type
journal article
Language
en
Open access
closed
Locations
  • The Lancet Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Rea Charitable Trust
  • Medical Research Council
  • National Multiple Sclerosis Society
  • Aims2Cure
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
Keywords
multiple sclerosis, risk factors, prodromal symptoms, etiology, causal pathways, endophenotypes, genetic factors, environmental factors, disease prevention, MS incidence
MeSH terms
Disease Susceptibility, Environment, Environmental Exposure, Humans, Multiple Sclerosis, Risk Factors, Sex Factors

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