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Cited by 354

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring

Shaw, Gary M., O'Malley, Cynthia D., Wasserman, Cathy R., Tolarova, Marie M., Lammer, Edward J.·1995·American Journal of Medical Genetics
DOI 10.1002/ajmg.1320590428
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Abstract

We investigated whether a woman's periconceptional use of a multivitamin containing folic acid was associated with a reduced risk for delivering offspring with a conotruncal heart defect or a limb deficiency. Data were derived from a population‐based case‐control study of fetuses and liveborn infants with conotruncal or limb defects among a 1987–88 cohort of births in California. Telephone interviews were conducted with mothers of 207 (87.0% of eligible) conotruncal cases, 178 (82.0%) limb defect cases, and of 481 (76.2%) randomly selected liveborn nonmalformed control infants. Reduced risks were observed for maternal use of multivitamins containing folic acid from one month before until two months after conception. Odds ratios and 95% confidence intervals for any compared to no multivitamin use were 0.70 (0.46–1.1) for conotruncal defects and 0.64 (0.41–1.0) for limb defects. Controlling for maternal race/ethnicity, age, education, gravidity, alcohol use, and cigarette use resulted in a further reduction to the odds ratio for conotruncal defects, 0.53 (0.34–0.85), but not for limb defects. Among non‐vitamin using women, consumption of cereal containing folic acid was also associated with reduced risks for both defects. Women who take multivitamins have 30–35% lower risk of delivering offspring with either conotruncal or limb defects. This association may not be attributable to folic acid specifically, but may be a consequence of other multivitamin components, or some unknown behaviors that highly correlate with regular use of a multivitamin. However, should the association prove causal, it offers an important opportunity for preventing thousands of serious birth defects. © 1995 Wiley‐Liss, Inc.

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Metadata

Authors
Shaw, G. M., O'Malley, C. D., Wasserman, C. R., Tolarova, M. M., & Lammer, E. J.
Venue
American Journal of Medical Genetics
Publisher
Wiley
Published
1995-12-04
Volume
59
Issue
4
Pages
536-545
ISSN
  • 0148-7299 (ISSN-L)
  • 1096-8628
DOI
10.1002/ajmg.1320590428
OpenAlex
W1981841305
Cited by
354
References
24
FWCI
6.28
Type
journal article
Language
en
Open access
closed

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Shaw, G. M., O'Malley, C. D., Wasserman, C. R., Tolarova, M. M., & Lammer, E. J. (1995). Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring. American Journal of Medical Genetics. https://doi.org/10.1002/ajmg.1320590428

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.