Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge: A Scientific Statement From the American Heart Association Council on Cardiovascular Disease in the Young: Endorsed by the American Academy of Pediatrics
Abstract
Prevention of congenital cardiovascular defects has been hampered by a lack of information about modifiable risk factors for abnormalities in cardiac development. Over the past decade, there have been major breakthroughs in the understanding of inherited causes of congenital heart disease, including the identification of specific genetic abnormalities for some types of malformations. Although relatively less information has been available on noninherited modifiable factors that may have an adverse effect on the fetal heart, there is a growing body of epidemiological literature on this topic. This statement summarizes the currently available literature on potential fetal exposures that might alter risk for cardiovascular defects. Information is summarized for periconceptional multivitamin or folic acid intake, which may reduce the risk of cardiac disease in the fetus, and for additional types of potential exposures that may increase the risk, including maternal illnesses, maternal therapeutic and nontherapeutic drug exposures, environmental exposures, and paternal exposures. Information is highlighted regarding definitive risk factors such as maternal rubella; phenylketonuria; pregestational diabetes; exposure to thalidomide, vitamin A cogeners, or retinoids; and indomethacin tocolysis. Caveats regarding interpretation of possible exposure-outcome relationships from case-control studies are given because this type of study has provided most of the available information. Guidelines for prospective parents that could reduce the likelihood that their child will have a major cardiac malformation are given. Issues related to pregnancy monitoring are discussed. Knowledge gaps and future sources of new information on risk factors are described.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
No clear association has been found in humans between moderate doses of caffeine ingestion during pregnancy and birth defects, including congenital heart disease.
“No clear association has been found in humans between moderate doses of caffeine ingestion during pregnancy and birth defects, including congenital heart disease (132).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [132]
Cites
Rosamond, W., Flegal, K., Friday, G., Furie, K., Go, A., Greenlund, K., Haase, N., Ho, M., Howard, V., Kissela, B., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.179918 · Cited by 3,277 · see citing works
The Continuing Epidemics of Obesity and Diabetes in the United States
Mokdad, A. H. (2001) · JAMA · doi:10.1001/jama.286.10.1195 · Cited by 2,730 · see citing works
Harris, M. I., Flegal, K. M., Cowie, C. C., Eberhardt, M. S., Goldstein, D. E., Little, R. R., Wiedmeyer, H.-M., & Byrd-Holt, D. D. (1998) · Diabetes Care · doi:10.2337/diacare.21.4.518 · Cited by 2,703 · see citing works
Buchanan, T. A., & Xiang, A. H. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524531 · Cited by 2,123 · see citing works
Maternal Pesticide Exposure from Multiple Sources and Selected Congenital Anomalies
Shaw, G. M., Wasserman, C. R., O’Malley, C. D., Nelson, V. E., & Jackson, R. J. (1999) · Epidemiology · doi:10.1097/00001648-199901000-00011 · Cited by 1,783 · see citing works
Clarren, S. K., & Smith, D. W. (1978) · New England Journal of Medicine · doi:10.1056/nejm197805112981906 · Cited by 1,359 · see citing works
Major congenital malformations after first-trimester exposure to ACE inhibitors
Cooper, W. O., Hernandez-Diaz, S., Arbogast, P. G., Dudley, J. A., Dyer, S., Gideon, P. S., Hall, K., & Ray, W. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055202 · Cited by 1,192 · see citing works
CONGENITAL HEART DISEASE: PREVALENCE AT LIVEBIRTH
Ferencz, C., Rubin, J. D., McCarter, R., Brenner, J. I., Neill, C. A., Perry, L. W., Hepner, S. I., & Downing, J. W. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113979 · Cited by 1,025 · see citing works
Genetic Basis for Congenital Heart Defects: Current Knowledge
Pierpont, M. E., Basson, C. T., Benson, D. W., Gelb, B. D., Giglia, T. M., Goldmuntz, E., McGee, G., Sable, C., Srivastava, D., & Webb, C. L. (2007) · Circulation · doi:10.1161/circulationaha.106.183056 · Cited by 844 · see citing works
Self-citationCongenital Cataract Following German Measles in the Mother
Gregg, N. M. (1941) · Springer eBooks · doi:10.1007/978-94-011-6621-8_22 · Cited by 839 · see citing works
Folic Acid Antagonists during Pregnancy and the Risk of Birth Defects
Hernández–Dı́az, S., Werler, M. M., Walker, A. M., & Mitchell, A. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011303432204 · Cited by 788 · see citing works
Birth defects and drugs in pregnancy
Heinonen, O. P., Slone, D., & Shapiro, S. (1977) · Medical Entomology and Zoology · Cited by 777 · see citing works
Roulston, A., Marcellus, R. C., & Branton, P. E. (1999) · Annual Review of Microbiology · doi:10.1146/annurev.micro.53.1.577 · Cited by 757 · see citing works
Teratogenicity of high vitamin A intake
Rothman, K. J., Moore, L. L., Singer, M. R., Nguyen, U.-S. D. T., Mannino, S., & Milunsky, A. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511233332101 · Cited by 754 · see citing works
Increasing Prevalence of Gestational Diabetes Mellitus (GDM) Over Time and by Birth Cohort
Dabelea, D., Snell‐Bergeon, J. K., Hartsfield, C. L., Bischoff, K. J., Hamman, R. F., & McDuffie, R. S. (2005) · Diabetes Care · doi:10.2337/diacare.28.3.579 · Cited by 707 · see citing works
The National Birth Defects Prevention Study
Yoon, P., Rasmussen, S., Lynberg, M. C., Moore, C., Anderka, M., Carmichael, S. L., Costa, P., Druschel, C. M., Hobbs, C., Romitti, P., et al. (2001) · Public Health Reports · doi:10.1093/phr/116.s1.32 · Cited by 696 · see citing works
Becerra, J. E., Khoury, M. J., Cordero, J. F., & Erickson, J. D. (1990) · PEDIATRICS · doi:10.1542/peds.85.1.1 · Cited by 622 · see citing works
Maternal Phenylketonuria and Hyperphenylalaninemia
Lenke, R. R., & Levy, H. L. (1980) · New England Journal of Medicine · doi:10.1056/nejm198011203032104 · Cited by 598 · see citing works
Åberg, A., Westbom, L., & Källén, B. A. J. (2001) · Early Human Development · doi:10.1016/s0378-3782(00)00125-0 · Cited by 597 · see citing works
Racial and Temporal Variations in the Prevalence of Heart Defects
Botto, L. D., Correa, A., & Erickson, J. D. (2001) · PEDIATRICS · doi:10.1542/peds.107.3.e32 · Cited by 567 · see citing works
Self-citationChemically induced birth defects
Schardein, J. L. (1986) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(86)90073-3 · Cited by 492 · see citing works
A Reevaluation of Risk of In Utero Exposure to Lithium
Cohen, L. S. (1994) · JAMA · doi:10.1001/jama.1994.03510260078033 · Cited by 475 · see citing works
Ambient Air Pollution and Risk of Birth Defects in Southern California
Ritz, B. R. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.1.17 · Cited by 463 · see citing works
An Increase in the Incidence of Gestational Diabetes Mellitus: Northern California, 1991–2000
Ferrara, A. M., Kahn, H. S., Quesenberry, C. P., Riley, C., & Hedderson, M. M. (2004) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000113623.18286.20 · Cited by 450 · see citing works
Ray, J. G. (2001) · QJM · doi:10.1093/qjmed/94.8.435 · Cited by 430 · see citing works
The Continuing Epidemic of Obesity in the United States
Mokdad, A. H., Serdula, M. K., Dietz, W. H., Bowman, B. A., Marks, J. S., & Koplan, J. P. (2000) · JAMA · doi:10.1001/jama.284.13.1650 · Cited by 415 · see citing works
Public Drinking Water Contamination and Birth Outcomes
Bove, F., Fulcomer, M. C., Klotz, J. B., Esmart, J., Dufficy, E. M., & Savrin, J. E. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117521 · Cited by 393 · see citing works
Warram, J. H., Królewski, A. S., Gottlieb, M. S., & Kahn, C. R. (1984) · New England Journal of Medicine · doi:10.1056/nejm198407193110304 · Cited by 392 · see citing works
Shaw, G. M., O’Malley, C. D., Wasserman, C. R., Tolarová, M. M., & Lammer, E. J. (1995) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320590428 · Cited by 354 · see citing works
Vogel, F., & Rathenberg, R. (1975) · Springer eBooks · doi:10.1007/978-1-4615-9068-2_4 · Cited by 342 · see citing works
Congenital heart block in newborns of mothers with connective tissue disease.
McCue, C. M., Mantakas, M. E., Tingelstad, J. B., et al. (1977) · Circulation · doi:10.1161/01.cir.56.1.82 · Cited by 332 · see citing works
Prospective multicentre study of pregnancy outcome after lithium exposure during first trimester
Jacobson, S., Ceolin, L. G., Kaur, P., Pastuszak, A. L., Einarson, T. R., Koren, G., Jones, K. L., Johnson, K., Sahn, D. J., Donnenfeld, A. E., et al. (1992) · The Lancet · doi:10.1016/0140-6736(92)90346-5 · Cited by 320 · see citing works
Safety of metronidazole in pregnancy: A meta-analysis
Burtin, P., Taddio, A., Ariburnu, O., Einarson, T. R., & Koren, G. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90567-7 · Cited by 313 · see citing works
Recognition of thalidomide defects.
SMITHELLS, R. W., & Newman, C. G. H. (1992) · Journal of Medical Genetics · doi:10.1136/jmg.29.10.716 · Cited by 276 · see citing works
Association of Maternal Systemic Lupus Erythematosus with Congenital Complete Heart Block
Chameides, L., Truex, R. C., Vetter, V. L., Rashkind, W. J., Galioto, F. M., & Noonan, J. A. (1977) · New England Journal of Medicine · doi:10.1056/nejm197712012972203 · Cited by 271 · see citing works
Schaefer-Graf, U. M., Buchanan, T. A., Xiang, A., Songster, G., Montoro, M., & Kjos, S. L. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(00)70217-1 · Cited by 270 · see citing works
Are obese women at higher risk for producing malformed offspring?
Waller, D. K., Mills, J. L., Simpson, J. L., Cunningham, G. C., Conley, M. R., Lassman, M. R., & Rhoads, G. G. (1994) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(94)70224-1 · Cited by 269 · see citing works
Neural Tube Defects in Embryos of Diabetic Mice: Role of the Pax-3 Gene and Apoptosis
Phelan, S. A., Ito, M., & Loeken, M. R. (1997) · Diabetes · doi:10.2337/diab.46.7.1189 · Cited by 264 · see citing works
Maternal corticosteroid use and risk of selected congenital anomalies
Carmichael, S. L., & Shaw, G. M. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990917)86:3 · Cited by 262 · see citing works
Multivitamin Supplementation and Risk of Brith Defects
Werler, M. M., Hayes, C., Louik, C., et al. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010070 · Cited by 258 · see citing works
Occurrence of Congenital Heart Defects in Relation to Maternal Multivitamin Use
Botto, L. D., Mulinare, J., & Erickson, J. D. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010291 · Cited by 257 · see citing works
Self-citationReefhuis, J., & Honein, M. A. (2004) · Birth Defects Research Part A: Clinical and Molecular Teratology · doi:10.1002/bdra.20065 · Cited by 253 · see citing works
Fluconazole-induced congenital anomalies in three infants
Pursley, T. J., Blomquist, I. K., Abraham, J., Andersen, H. F., & Bartley, J. A. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.2.336 · Cited by 246 · see citing works
Chemically Induced Birth Defects
Schardein, J. L. (2000) · CRC Press eBooks · doi:10.3109/9780203909904 · Cited by 246 · see citing works
Gilboa, S. M., Mendola, P., Olshan, A. F., Langlois, P. H., Savitz, D. A., LOOMIS, D. P., Herring, A. H., & Fixler, D. E. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi189 · Cited by 240 · see citing works
Cardiovascular malformations in infants of diabetic mothers
Wren, C., Birrell, G., & Hawthorne, G. (2003) · Heart · doi:10.1136/heart.89.10.1217 · Cited by 230 · see citing works
Maternal diabetes mellitus and infant malformations
Sheffield, J. S. (2002) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(02)02242-1 · Cited by 230 · see citing works
No Association between Coffee Consumption and Adverse Outcomes of Pregnancy
Linn, S., Schoenbaum, S. C., Monson, R. R., ROSNER, B. A., Stubblefield, P. G., & Ryan, K. J. (1982) · New England Journal of Medicine · doi:10.1056/nejm198201213060304 · Cited by 225 · see citing works
Brenner, H., Berg, G., Lappus, N., Kliebsch, U., Bode, G., & Boeing, H. (1999) · PubMed · Cited by 216 · see citing works
Ylinen, K., Aula, P., Stenman, U., Kesäniemi-Kuokkanen, T., & Teramo, K. A. (1984) · BMJ · doi:10.1136/bmj.289.6441.345 · Cited by 212 · see citing works
Is metronidazole teratogenic? A meta‐analysis
Caro-Paton, T., Carvajal, A., de Diego, I. M., Arias, L. H. M., Alvarez-Requejo, A., & Pinilla, E. R. (1997) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1997.00660.x · Cited by 209 · see citing works
First-trimester drug use and congenital disorders
Jick, H. (1981) · JAMA · doi:10.1001/jama.246.4.343 · Cited by 207 · see citing works
Relationship between gestational cocaine use and pregnancy outcome: A meta‐analysis
Lutiger, B., Graham, K., Einarson, T. R., & Koren, G. (1991) · Teratology · doi:10.1002/tera.1420440407 · Cited by 207 · see citing works
Moore, L. L., Singer, M. R., Bradlee, M. L., Rothman, K. J., & Milunsky, A. (2000) · Epidemiology · doi:10.1097/00001648-200011000-00013 · Cited by 206 · see citing works
Johnson, F. N. (1980) · Springer eBooks · doi:10.1007/978-94-011-7197-7 · Cited by 197 · see citing works
Congenital Cataract Following German Measles in the Mother
Gregg, N. M. (1991) · Epidemiology and Infection · doi:10.1017/s0950268800048627 · Cited by 196 · see citing works
Moise, K. J. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(11)90763-7 · Cited by 194 · see citing works
Macias, E. G. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92165-0 · Cited by 194 · see citing works
First-Trimester Drug Use and Congenital Disorders
Jick, H. (1981) · JAMA · doi:10.1001/jama.1981.03320040015021 · Cited by 191 · see citing works
Vitamin E Decreases the Occurrence of Malformations in the Offspring of Diabetic Rats
Simán, C. M., & Eriksson, U. J. (1997) · Diabetes · doi:10.2337/diab.46.6.1054 · Cited by 189 · see citing works
Why Don't Women With Diabetes Plan Their Pregnancies?
Holing, E. V., Beyer, C. S., Brown, Z. A., & Connell, F. A. (1998) · Diabetes Care · doi:10.2337/diacare.21.6.889 · Cited by 182 · see citing works
Cardiovascular Birth Defects and Antenatal Exposure to Female Sex Hormones
Heinonen, O. P., Slone, D., Monson, R. R., et al. (1977) · New England Journal of Medicine · doi:10.1056/nejm197701132960202 · Cited by 180 · see citing works
Periconceptional folic acid containing multivitamin supplementation
Czeizel, A. E. (1998) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(98)00061-x · Cited by 176 · see citing works
Bracken, M. (1990) · PubMed · Cited by 168 · see citing works
Attributable Fraction for Cardiac Malformations
Wilson, P. D., Loffredo, C. A., Correa, A., & Ferencz, C. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009666 · Cited by 168 · see citing works
Self-citationAn association of human congenital cardiac malformations and drinking water contaminants
Goldberg, S. J., Lebowitz, M. D., Graver, E. J., & Hicks, S. (1990) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(90)90473-3 · Cited by 167 · see citing works
Influence of paternal age, smoking, and alcohol consumption on congenital anomalies
Savitz, D. A., Schwingl, P. J., & Keels, M. A. (1991) · Teratology · doi:10.1002/tera.1420440409 · Cited by 165 · see citing works
EXOGENOUS HORMONES AND OTHER DRUG EXPOSURES OF CHILDREN WITH CONGENITAL HEART DISEASE1
Rothman, K. J., Fyler, D. C., Goldblatt, A., et al. (1979) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112701 · Cited by 164 · see citing works
Congenital Heart Disease in Relation to Maternal Use of Bendectin and Other Drugs in Early Pregnancy
Zierler, S., & Rothman, K. J. (1985) · New England Journal of Medicine · doi:10.1056/nejm198508083130603 · Cited by 158 · see citing works
Nonsteroidal anti-inflammatory drugs in early pregnancy
Ericson, A., & Källén, B. A. J. (2001) · Reproductive Toxicology · doi:10.1016/s0890-6238(01)00137-x · Cited by 152 · see citing works
Ebstein's malformation of the tricuspid valve: Genetic and environmental factors
Correa, A., Ferencz, C., Neill, C. A., Wilson, P. D., & Boughman, J. A. (1994) · Teratology · doi:10.1002/tera.1420500208 · Cited by 152 · see citing works
Self-citationWrensch, M., Yost, M. G., Miike, R., Lee, G., & Touchstone, J. (1999) · Epidemiology · doi:10.1097/00001648-199909000-00010 · Cited by 152 · see citing works
Trihalomethanes in Public Water Supplies and Adverse Birth Outcomes
Dodds, L., King, W. D., Woolcott, C. G., & Pole, J. D. (1999) · Epidemiology · doi:10.1097/00001648-199905000-00007 · Cited by 152 · see citing works
Maternal Life Event Stress and Congenital Anomalies
Carmichael, S. L., & Shaw, G. M. (2000) · Epidemiology · doi:10.1097/00001648-200001000-00008 · Cited by 151 · see citing works
Hagay, Z. J., Weiss, Y., Zusman, I., Peled-Kamar, M., Reece, E. A., Eriksson, U. J., & Groner, Y. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)91323-8 · Cited by 149 · see citing works
Preconception Care of Women With Diabetes
Kendrick, J. M. (2004) · The Journal of Perinatal & Neonatal Nursing · doi:10.1097/00005237-200401000-00003 · Cited by 143 · see citing works
Maternal Risk Factors and Major Associated Defects in Infants with Down Syndrome
Torfs, C. P., & Christianson, R. E. (1999) · Epidemiology · doi:10.1097/00001648-199905000-00013 · Cited by 143 · see citing works
Takizawa, T., Ohashi, K., & Nakanishi, Y. (1996) · Journal of Virology · doi:10.1128/jvi.70.11.8128-8132.1996 · Cited by 142 · see citing works
Croen, L., Shaw, G. M., Sanbonmatsu, L., Selvin, S., & Buffler, P. A. (1997) · Epidemiology · doi:10.1097/00001648-199707000-00001 · Cited by 142 · see citing works
Paternal age and the occurrence of birth defects.
Lian, Z.-H., Zack, M. M., & Erickson, J. D. (1986) · PubMed · Cited by 140 · see citing works
Cardiovascular abnormalities in infants prenatally exposed to cocaine
Lipshultz, S. E., Frassica, J. J., & Orav, E. J. (1991) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)81842-6 · Cited by 138 · see citing works
Preconception Care of Women With Diabetes
American Diabetes Association (2004) · Diabetes Care · doi:10.2337/diacare.27.2007.s76 · Cited by 138 · see citing works
The teratogenic risk of trimethoprim-sulfonamides: a population based case-control study
Czeizel, A. E., Rockenbauer, M., Sørensen, H. T., & Olsen, J. (2001) · Reproductive Toxicology · doi:10.1016/s0890-6238(01)00178-2 · Cited by 136 · see citing works
Green, D. M., Zevon, M. A., Lowrie, G. S., Seigelstein, N., & Hall, B. C. (1991) · New England Journal of Medicine · doi:10.1056/nejm199107183250301 · Cited by 134 · see citing works
Risk of specific congenital abnormalities in offspring of women with diabetes
Nielsen, G. L., Nørgård, B. M., Puhó, E., et al. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01477.x · Cited by 132 · see citing works
Prenatal use of metronidazole and birth defects: no association.
Piper, J. M., Mitchel, E. F., & Ray, W. A. (1993) · PubMed · Cited by 131 · see citing works
Birth Defects Related to Bendectin Use in Pregnancy
Mitchell, A. A. (1981) · JAMA · doi:10.1001/jama.1981.03310470025020 · Cited by 127 · see citing works
Congenital Heart Defects, Maternal Febrile Illness, and Multivitamin Use: A Population-Based Study
Botto, L. D., Lynberg, M. C., & Erickson, J. D. (2001) · Epidemiology · doi:10.1097/00001648-200109000-00004 · Cited by 126 · see citing works
Self-citationLeading Major Congenital Malformations Among Minority Groups in the United States, 1981-1986
Chavez, G. F., Cordero, J. F., & Becerra, J. E. (1989) · JAMA · doi:10.1001/jama.1989.03420020047012 · Cited by 125 · see citing works
The use of lithium and management of women with bipolar disorder during pregnancy and lactation.
Llewellyn, A., Stowe, Z. N., & Strader, J. R. (1998) · PubMed · Cited by 122 · see citing works
CONGENITAL RUBELLA SYNDROME IN THE UNITED STATES, 1970–1985
Cochi, S. L., EDMONDS, L. E., Dyer, K., Greaves, W. L., Marks, J. S., Rovira, E. Z., Preblud, S. R., & Orenstein, W. A. (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115138 · Cited by 120 · see citing works
Teratogenic effects of diabetes mellitus in the rat. Prevention by vitamin E
Viana, M., Herrera, E., & Bonet, B. (1996) · Diabetologia · doi:10.1007/bf00400652 · Cited by 118 · see citing works
Epilepsy and pregnancy: Report of an Epilepsy Research Foundation Workshop
Barrett, C., & Richens, A. (2003) · Epilepsy Research · doi:10.1016/s0920-1211(02)00237-1 · Cited by 118 · see citing works
Loffredo, C. A., Silbergeld, E. K., Ferencz, C., et al. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.6.529 · Cited by 118 · see citing works
Watanabe, M., Choudhry, A., Berlan, M., et al. (1998) · Development · doi:10.1242/dev.125.19.3809 · Cited by 117 · see citing works
Scanlon, K. S., Ferencz, C., Loffredo, C. A., Wilson, P. D., Correa, A., Khoury, M. J., & Willett, W. C. (1998) · PubMed · Cited by 117 · see citing works
Self-citationExposure to prescribed drugs in pregnancy and association with congenital malformations.
Bracken, M. B., & Tr, H. (1981) · PubMed · Cited by 117 · see citing works
Risk factors for conotruncal cardiac defects in Atlanta
Adams, M. M., Mulinare, J., & Dooley, K. J. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90199-x · Cited by 116 · see citing works
Hanson, J. W. (1986) · Teratology · doi:10.1002/tera.1420330314 · Cited by 115 · see citing works
Maternal hyperthermia during pregnancy and cardiovascular malformations in the offspring
Tikkanen, J., & Heinonen, O. P. (1991) · European Journal of Epidemiology · doi:10.1007/bf00218673 · Cited by 115 · see citing works
Paternal age and the risk of congenital heart defects
Olshan, A. F., Schnitzer, P. G., & Baird, P. A. (1994) · Teratology · doi:10.1002/tera.1420500111 · Cited by 114 · see citing works
Selected birth defects in relation to caffeine-containing beverages
Rosenberg, L. (1982) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1982.03320350033024 · Cited by 114 · see citing works
Total anomalous pulmonary venous return: Familial and environmental factors
Correa‐Villaseñor, A., Ferencz, C., Boughman, J. A., et al. (1991) · Teratology · doi:10.1002/tera.1420440408 · Cited by 113 · see citing works
Maternal Prepregnancy Weight and Congenital Heart Defects in the Offspring
Watkins, M. L., & Botto, L. D. (2001) · Epidemiology · doi:10.1097/00001648-200107000-00014 · Cited by 111 · see citing works
Self-citationMaternal diabetes: The risk for specific birth defects
Ramos-Arroyo, M. A., Rodríguez‐Pinilla, E., & Cordero, J. F. (1992) · European Journal of Epidemiology · doi:10.1007/bf00146367 · Cited by 109 · see citing works
TIMING OF STRICT DIET IN RELATION TO FETAL DAMAGE IN MATERNAL PHENYLKETONURIA
Drogari, E., Beasley, M., Smith, I., et al. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91418-8 · Cited by 108 · see citing works
Martínez‐Frías, M. L., Bermejo, E., Rodríguez‐Pinilla, E., et al. (2004) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20017 · Cited by 108 · see citing works
Maternal lifestyle factors and risk for ventricular septal defects
Williams, L. J., Correa, A., & Rasmussen, S. A. (2004) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.10145 · Cited by 108 · see citing works
Self-citationPreconceptional Folate Intake and Malformations of the Cardiac Outflow Tract
Scanlon, K. S., Ferencz, C., Loffredo, C. A., Wilson, P. D., Correa, A., Khoury, M. J., & Willett, W. C. (1998) · Epidemiology · doi:10.1097/00001648-199801000-00019 · Cited by 108 · see citing works
Self-citationLevy, H. L., Guldberg, P., Güttler, F., et al. (2001) · Pediatric Research · doi:10.1203/00006450-200105000-00005 · Cited by 107 · see citing works
Multifactorial basis of the syndrome of diabetic embryopathy
Reece, E. A., Homko, C. J., & Wu, Y.-K. (1996) · Teratology · doi:10.1002/(sici)1096-9926(199610)54:4 · Cited by 105 · see citing works
Genetic Assembly of the Heart: Implications for Congenital Heart Disease
Srivastava, D. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.451 · Cited by 103 · see citing works
Maternal height and prepregnancy body mass index as risk factors for selected congenital anomalies
Shaw, G. M., Todoroff, K., Schaffer, D., & Selvin, S. (2000) · Paediatric and Perinatal Epidemiology · doi:10.1046/j.1365-3016.2000.00274.x · Cited by 102 · see citing works
Maternal Fever, Multivitamin Use, and Selected Birth Defects: Evidence of Interaction?
Botto, L. D., Erickson, J. D., Mulinare, J., Lynberg, M. C., & Liu, Y. (2002) · Epidemiology · doi:10.1097/00001648-200207000-00019 · Cited by 101 · see citing works
Self-citationEriksson, U. J., & Simán, C. M. (1996) · Diabetes · doi:10.2337/diab.45.11.1497 · Cited by 100 · see citing works
Health Deficiencies in Cape Breton County, Nova Scotia, Canada, 1950–1995
Veugelers, P. J., & Guernsey, J. R. (1999) · Epidemiology · doi:10.1097/00001648-199909000-00006 · Cited by 98 · see citing works
Mills, J. L., Simpson, J. L., Cunningham, G. C., Conley, M. R., & Rhoads, G. G. (1997) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(97)70434-4 · Cited by 97 · see citing works
The Relation of Aspirin Use during the First Trimester of Pregnancy to Congenital Cardiac Defects
Werler, M. M., Mitchell, A. A., & Shapiro, S. (1989) · New England Journal of Medicine · doi:10.1056/nejm198912143212404 · Cited by 97 · see citing works
White-Black Differences in Cardiovascular Malformations in Infancy and Socioeconomic Factors
Correa, A., McCarter, R., Downing, J. W., & Ferencz, C. (1991) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116101 · Cited by 95 · see citing works
Self-citationTeratogenic Risk with Etretinate and Acitretin Treatment
Geiger, J.-M., Baudin, M., & Saurat, J. ‐. (2009) · Dermatology · doi:10.1159/000246811 · Cited by 94 · see citing works
Congenital malformations in an infant born to a woman treated with fluconazole.
Be, L., Feinberg, M., Jj, A., & Ar, M. (1992) · PubMed · Cited by 94 · see citing works
The Precautionary Principle and Medical Decision Making
Resnik, D. B. (2004) · The Journal of Medicine and Philosophy A Forum for Bioethics and Philosophy of Medicine · doi:10.1080/03605310490500509 · Cited by 93 · see citing works
Pregnancy Outcomes after Maternal Exposure to Fluconazole
Jick, S. S. (1999) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.19.3.221.30919 · Cited by 92 · see citing works
Janssen, P. A., Rothman, I. K., & Schwartz, S. M. (1996) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.1996.tb00026.x · Cited by 92 · see citing works
The National Children's Study of environmental effects on child health and development.
Branum, A. M., Collman, G. W., Correa, A., Keim, S. A., Kessel, W., Kimmel, C. A., Klebanoff, M. A., Longnecker, M. P., Mendola, P., Rigas, M. L., et al. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.111-1241458 · Cited by 89 · see citing works
Self-citationShaw, G. M. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg013 · Cited by 88 · see citing works
Maternal smoking and congenital heart defects
Källén, K. (1999) · European Journal of Epidemiology · doi:10.1023/a:1007671631188 · Cited by 87 · see citing works
Drinking water chlorination and delivery outcome—a registry-based study in Sweden
Källén, B. A. J., & Robert, E. (2000) · Reproductive Toxicology · doi:10.1016/s0890-6238(00)00086-1 · Cited by 87 · see citing works
Teratogenicity of anticonvulsant drugs. II: A prospective study
Kelly, T. E., Edwards, P., Rein, M., et al. (1984) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320190303 · Cited by 87 · see citing works
CONGENITAL MALFORMATIONS IN AN INFANT BORN TO A WOMAN TREATED WITH FLUCONAZOLE
&NA; (1992) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199211120-00017 · Cited by 86 · see citing works
Is Moderate Drinking During Pregnancy Associated With an Increased Risk for Malformations?
Mills, J. L., & Graubard, B. I. (1987) · PEDIATRICS · doi:10.1542/peds.80.3.309 · Cited by 85 · see citing works
Lipshultz, S. E., Easley, K. A., Orav, E. J., Kaplan, S., Starc, T. J., Bricker, J. T., Lai, W. W., Moodie, D. S., Sopko, G. S., SCHLUCHTER, M. D., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09607-1 · Cited by 85 · see citing works
Mulder, G. B., Manley, N. R., Grant, J. H., Schmidt, K., Zeng, W., Eckhoff, C., & Maggio‐Price, L. (2000) · Teratology · doi:10.1002/1096-9926(200010)62:4 · Cited by 84 · see citing works
Issues and Reviews in Teratology
(1990) · Springer eBooks · doi:10.1007/978-1-4613-0521-7 · Cited by 83 · see citing works
Sharpe, P., Chan, A. C., Haan, E., & Hiller, J. E. (2005) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20172 · Cited by 83 · see citing works
Socio‐economic status and risk of conotruncal heart defects and orofacial clefts
Carmichael, S. L., Nelson, V. E., Shaw, G. M., et al. (2003) · Paediatric and Perinatal Epidemiology · doi:10.1046/j.1365-3016.2003.00498.x · Cited by 83 · see citing works
Etiology and Prevention of Congenital Anomalies Among Infants of Overt Diabetic Women
Cousins, L. M. (1991) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-199134030-00002 · Cited by 83 · see citing works
Antenatal Indomethacin‐Adverse Fetal Effects Confirmed
Souter, D. J., Harding, J. E., McCowan, L. M. E., O’Donnell, C. P., McLeay, E., & Baxendale, H. (1998) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.1998.tb02949.x · Cited by 82 · see citing works
Risk factors for heart disease associated with abnormal sidedness
KUEHL, K. S., & Loffredo, C. A. (2002) · Teratology · doi:10.1002/tera.10099 · Cited by 81 · see citing works
Maternal Periconceptional Vitamins: Interactions with Selected Factors and Congenital Anomalies?
Shaw, G. M., Nelson, V. E., Carmichael, S. L., et al. (2002) · Epidemiology · doi:10.1097/00001648-200211000-00005 · Cited by 81 · see citing works
Do Multivitamin Supplements Attenuate the Risk for Diabetes-Associated Birth Defects?
Correa, A., Botto, L. D., Liu, Y., Mulinare, J., & Erickson, J. D. (2003) · PEDIATRICS · doi:10.1542/peds.111.s1.1146 · Cited by 80 · see citing works
Self-citationPlace of Maternal Rubella in the Aetiology of Congenital Heart Disease
Campbell, M. (1961) · BMJ · doi:10.1136/bmj.1.5227.691 · Cited by 80 · see citing works
Parental age effects on the occurrence of new mutations for the Marfan syndrome
Murdoch, J. L., Walker, B. A., & McKusick, V. A. (1972) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1957.tb01406.x · Cited by 79 · see citing works
Rasanen, J. P., & Jouppila, P. I. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90163-9 · Cited by 78 · see citing works
Maternal vitamin A supplementation in relation to selected birth defects
Werler, M. M., Lammer, E. J., Rosenberg, L. A., & Mitchell, A. A. (1990) · Teratology · doi:10.1002/tera.1420420506 · Cited by 76 · see citing works
Wilkinson, A., Aynsley-Green, A., & Mitchell, M. D. (1979) · Archives of Disease in Childhood · doi:10.1136/adc.54.12.942 · Cited by 74 · see citing works
Reece, E. A., & Wu, Y.-K. (1997) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(97)70602-1 · Cited by 74 · see citing works
Nausea during Pregnancy and Congenital Heart Defects: A Population-based Case-Control Study
Boneva, R. S., Moore, C. A., Botto, L. D., Wong, L.-Y., & Erickson, J. D. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009880 · Cited by 72 · see citing works
Self-citationZenker, M., Klinge, J., Krüger, C., et al. (1998) · PubMed · Cited by 72 · see citing works
Risk of malformations and other outcomes in children exposed to fluconazole in utero
Sørensen, H. T., Nielsen, G. L., Olesen, C., Larsen, H., Steffensen, F. H., Schønheyder, H. C., Olsen, J., & Czeizel, A. E. (1999) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1999.00989.x · Cited by 71 · see citing works
Indomethacin Tocolysis Increases Postnatal Patent Ductus Arteriosus Severity
Hammerman, C., Glaser, J., Kaplan, M., Schimmel, M. S., Ferber, B., & Eidelman, A. I. (1998) · PEDIATRICS · doi:10.1542/peds.102.5.e56 · Cited by 71 · see citing works
THE OCCURRENCE OF CONGENITAL DEFECTS IN CHILDREN FOLLOWING MATERNAL RUBELLA DURING PREGNANCY
Gregg, N. M., Beavis, W. R., Heseltine, M., et al. (1945) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1945.tb96480.x · Cited by 71 · see citing works
Role of Nutrition in Pregnancy With Phenylketonuria and Birth Defects
Matalon, K. M., Acosta, P. B., & Azen, C. G. (2003) · PEDIATRICS · doi:10.1542/peds.112.s4.1534 · Cited by 69 · see citing works
Prostaglandin Synthetase Inhibitors in Pregnancy
den Veyver, I. B. V., & Moise, K. J. (1993) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199307000-00026 · Cited by 69 · see citing works
Risk factors for conal malformations of the heart
Tikkanen, J., & Heinonen, O. P. (1992) · European Journal of Epidemiology · doi:10.1007/bf03334972 · Cited by 68 · see citing works
Risk factors for ventricular septal defect in finland
Tikkanen, J., & Heinonen, O. P. (1991) · Public Health · doi:10.1016/s0033-3506(05)80283-5 · Cited by 68 · see citing works
Cardiac Complications in Children With Human Immunodeficiency Virus Infection
Starc, T. J., Lipshultz, S. E., Kaplan, S., et al. (1999) · PEDIATRICS · doi:10.1542/peds.104.2.e14 · Cited by 67 · see citing works
Dolk, H. M., & Nichols, R. (1999) · International Journal of Epidemiology · doi:10.1093/ije/28.5.941 · Cited by 66 · see citing works
Association of the Common Cold in the First Trimester of Pregnancy With Birth Defects
Zhang, J., & Cai, W.-W. (1993) · PEDIATRICS · doi:10.1542/peds.92.4.559 · Cited by 65 · see citing works
Moore, J. A. (1995) · Reproductive Toxicology · doi:10.1016/0890-6238(94)00069-7 · Cited by 65 · see citing works
Teratogen update: Fetal effects of indomethacin administration during pregnancy
Norton, M. E. (1997) · Teratology · doi:10.1002/(sici)1096-9926(199710)56:4 · Cited by 64 · see citing works
Lithium Treatment of Women During Pregnancy and in the Post-Delivery Period
Weinstein, M. R. (1980) · Springer eBooks · doi:10.1007/978-94-011-7197-7_48 · Cited by 63 · see citing works
Risk factors for atrial septal defect
Tikkanen, J., & Heinonen, O. P. (1992) · European Journal of Epidemiology · doi:10.1007/bf00146368 · Cited by 62 · see citing works
Orr, M. F., Bove, F., Kaye, W., et al. (2002) · International Journal of Hygiene and Environmental Health · doi:10.1078/1438-4639-00126 · Cited by 61 · see citing works
Holmes, L. B. (1999) · Teratology · doi:10.1002/(sici)1096-9926(199901)59:1 · Cited by 61 · see citing works
Association between maternal obesity and fetal cardiac malformations in African Americans.
Mikhail, L., Walker, C. K., & Mittendorf, R. L. (2002) · PubMed · Cited by 60 · see citing works
Coffee Consumption, Birthweight, and Reproductive Failures
Olsen, J., Overvad, K., & Frische, G. (1991) · Epidemiology · doi:10.1097/00001648-199109000-00011 · Cited by 60 · see citing works
Infants with single ventricle: A population‐based epidemiological study
Steinberger, E. K., Ferencz, C., & Loffredo, C. A. (2002) · Teratology · doi:10.1002/tera.10017 · Cited by 59 · see citing works
Risk factors for cardiovascular malformations in Finland
Tikkanen, J., & Heinonen, O. P. (1990) · European Journal of Epidemiology · doi:10.1007/bf00151707 · Cited by 58 · see citing works
Safety of Pregnancy After Discontinuation of Isotretinoin
Dai, W. S. (1989) · Archives of Dermatology · doi:10.1001/archderm.1989.01670150052005 · Cited by 54 · see citing works
Maternal smoking and the risk of congenital birth defects: a cohort study.
Woods, S. E., & Raju, U. (2002) · PubMed · Cited by 54 · see citing works
Cholesterol biosynthesis inhibited by BM15.766 induces holoprosencephaly in the rat
Kolf‐Clauw, M., Chevy, F., Siliart, B. S., Wolf, C., Mulliez, N., & Roux, C. (1997) · Teratology · doi:10.1002/(sici)1096-9926(199709)56:3 · Cited by 53 · see citing works
Rouse, B. M., & Azen, C. G. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2003.10.062 · Cited by 53 · see citing works
CONGENITAL HEART DEFECTS FOLLOWING MATERNAL RUBELLA DURING PREGNANCY
Stuckey, D. S. (1956) · Heart · doi:10.1136/hrt.18.4.519 · Cited by 52 · see citing works
Wiseman, R. A., & Dodds-Smith, I. C. (1984) · Teratology · doi:10.1002/tera.1420300308 · Cited by 52 · see citing works
Nonsteroidal anti-inflammatory drugs during pregnancy
Ostensen, M. (1998) · Scandinavian Journal of Rheumatology · doi:10.1080/03009742.1998.11720787 · Cited by 52 · see citing works
Trihalomethane Exposures from Municipal Water Supplies and Selected Congenital Malformations
Shaw, G. M., Ranatunga, D. K., Quach, T., Neri, E., Correa, A., & Neutra, R. (2003) · Epidemiology · doi:10.1097/01.ede.0000050697.18634.a6 · Cited by 50 · see citing works
Self-citationHornberger, L. K., Lipshultz, S. E., Easley, K. A., et al. (2000) · American Heart Journal · doi:10.1067/mhj.2000.109645 · Cited by 49 · see citing works
Expression of the Sonic Hedgehog gene in human embryos with neural tube defects
Kirillova, I. A., Novikova, I., Augé, J., Audollent, S., Esnault, D., Encha‐Razavi, F., Lazjuk, G. I., Attié‐Bitach, T., & Vekemans, M. J. J. (2000) · Teratology · doi:10.1002/(sici)1096-9926(200005)61:5 · Cited by 48 · see citing works
Purkinje cell deficits in nonhuman primates following weekly exposure to ethanol during gestation
Bonthius, D. J., Bonthius, D. J., Napper, R. M. A., Astley, S. J., Clarren, S. K., & West, J. R. (1996) · Teratology · doi:10.1002/(sici)1096-9926(199604)53:4 · Cited by 47 · see citing works
Shaw, G. M., Malcoe, L. H., Swan, S. H., et al. (1992) · European Journal of Epidemiology · doi:10.1007/bf00145398 · Cited by 46 · see citing works
Person-to-Person Transfer of Transdermal Drug-Delivery Systems: A Case Report
Reed, M. T., & Hamburg, E. L. (1986) · New England Journal of Medicine · doi:10.1056/nejm198604243141717 · Cited by 45 · see citing works
A population-based case-control teratologic study of ampicillin treatment during pregnancy
Czeizel, A. E., Rockenbauer, M., Sørensen, H. T., et al. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.113907 · Cited by 44 · see citing works
CONGENITAL HEART DISEASE FOLLOWING MATERNAL RUBELLA DURING PREGNANCY
Gibson, S. (1952) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1952.02040070063007 · Cited by 44 · see citing works
Vitamin A and Cardiac Outflow Tract Defects
Botto, L. D., Loffredo, C. A., Scanlon, K. S., Ferencz, C., Khoury, M. J., Wilson, P. D., & Correa, A. (2001) · Epidemiology · doi:10.1097/00001648-200109000-00005 · Cited by 44 · see citing works
Self-citationTeratogenicity of psychotherapeutic medications.
Elia, J., Katz, I. R., & Gm, S. (1987) · PubMed · Cited by 43 · see citing works
Krämer, W., Saade, G. R., Belfort, M. A., et al. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70221-8 · Cited by 43 · see citing works
Warkany, J. (1988) · Teratology · doi:10.1002/tera.1420380607 · Cited by 42 · see citing works
Can the Pill Cause Birth Defects?
Nora, J. J., & Nora, A. H. (1974) · New England Journal of Medicine · doi:10.1056/nejm197410032911410 · Cited by 40 · see citing works
Maternal hormone therapy and congenital heart disease
Ferencz, C., Matanoski, G. M., Wilson, P. D., et al. (1980) · Teratology · doi:10.1002/tera.1420210213 · Cited by 40 · see citing works
KUEHL, K. S., & Loffredo, C. A. (2003) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.10015 · Cited by 39 · see citing works
Prenatal Zidovudine Use and Congenital Anomalies in a Medicaid Population
Newschaffer, C. J., Cocroft, J. R., Anderson, C. E., et al. (2000) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200007010-00009 · Cited by 38 · see citing works
Effect of fathers' age and birth order on occurrence of congenital heart disease.
Zhan, S. Y., Lian, Z.-H., Zheng, D. Z., et al. (1991) · Journal of Epidemiology & Community Health · doi:10.1136/jech.45.4.299 · Cited by 38 · see citing works
Etiology and Prevention of Congenital Anomalies Among Infants of Overt Diabetic Women
Cousins, L. M. (1991) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-199109000-00002 · Cited by 37 · see citing works
Maternal Water Consumption During Pregnancy and Congenital Cardiac Anomalies
Shaw, G. M., Sh, S., Harris, J. A., et al. (1990) · Epidemiology · doi:10.1097/00001648-199005000-00005 · Cited by 37 · see citing works
Shaw, G., Wasserman, C. R., Block, G., et al. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91377-x · Cited by 37 · see citing works
Pharmacotherapy of Psychiatric Disorder in Pregnancy and during Breastfeeding: A Review
Thiels, C. (1987) · Pharmacopsychiatry · doi:10.1055/s-2007-1017092 · Cited by 37 · see citing works
Muntoni, S., Batetta, B., Dessì, S., Muntoni, S., & Pani, P. (1992) · European Journal of Epidemiology · doi:10.1007/bf00145349 · Cited by 37 · see citing works
Kousseff, B. G. (1999) · Current Opinion in Pediatrics · doi:10.1097/00008480-199908000-00014 · Cited by 37 · see citing works
Risk factors for coarctation of the aorta
Tikkanen, J., & Heinonen, O. P. (1993) · Teratology · doi:10.1002/tera.1420470608 · Cited by 35 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591 · see citing works
Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000757 · Cited by 9,175 · see citing works
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036 · see citing works
Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Beaton, A. Z., Boehme, A. K., Buxton, A. E., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001123 · Cited by 8,300 · see citing works
Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146 · see citing works
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333 · see citing works
Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Alonso, A., Beaton, A. Z., Bittencourt, M. S., Boehme, A. K., Buxton, A. E., Carson, A. P., Commodore-Mensah, Y., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001052 · Cited by 5,987 · see citing works
Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149 · see citing works
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797 · see citing works
Heart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192667 · Cited by 5,700 · see citing works
Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31828124ad · Cited by 5,292 · see citing works
Birth prevalence of congenital heart disease worldwide
van der Linde, D., Konings, E. E. M., Slager, M. A., Witsenburg, M., Helbing, W. A., Takkenberg, J. J. M., & Roos-Hesselink, J. W. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.08.025 · Cited by 3,452 · see citing works
Donofrio, M. T., Moon-Grady, A. J., Hornberger, L. K., Copel, J. A., Sklansky, M. S., Abuhamad, A., Cuneo, B. F., Huhta, J. C., Jonas, R. A., Krishnan, A., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437597.44550.5d · Cited by 1,275 · see citing works
Pierpont, M. E., Brueckner, M., Chung, W. K., Garg, V., Lacro, R. V., McGuire, A. L., Mital, S., Priest, J. R., Pu, W. T., Roberts, A., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000606 · Cited by 654 · see citing works
The Safety of Ingested Caffeine: A Comprehensive Review
Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00080 · Cited by 557 · see citing works
The neural crest in cardiac congenital anomalies
Keyte, A., & Hutson, M. R. (2012) · Differentiation · doi:10.1016/j.diff.2012.04.005 · Cited by 259 · see citing works
Self-organizing human cardiac microchambers mediated by geometric confinement
Ma, Z., Wang, J., Loskill, P., Huebsch, N., Koo, S., Svedlund, F. L., Marks, N. C., Hua, E. W., Grigoropoulos, C. P., Conklin, B. R., et al. (2015) · Nature Communications · doi:10.1038/ncomms8413 · Cited by 214 · see citing works
Wu, Y., Liu, B., Sun, Y., Du, Y., Santillan, M. K., Santillan, D. A., Snetselaar, L. G., & Bao, W. (2020) · Diabetes Care · doi:10.2337/dc20-0261 · Cited by 185 · see citing works
N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes
Moazzen, H., Lu, X., Ma, N. L., Velenosi, T. J., Urquhart, B. L., Wisse, L. J., Gittenberger-de Groot, A. C., & Feng, Q. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-46 · Cited by 111 · see citing works
Mlynarski, E. E., Sheridan, M. B., Xie, M., Guo, T., Racedo, S. E., McDonald-McGinn, D. M., Gai, X., Chow, E. W. C., Vorstman, J., Swillen, A., et al. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.03.007 · Cited by 74 · see citing works
Agha, M. M., Glazier, R. H., Moineddin, R., Moore, A. M., & Guttmann, A. (2011) · Birth Defects Research Part A: Clinical and Molecular Teratology · doi:10.1002/bdra.22857 · Cited by 58 · see citing works
- Authors
- Jenkins, K. J., Correa, A., Feinstein, J. A., Botto, L., Britt, A. E., Daniels, S. R., Elixson, M., Warnes, C. A., & Webb, C. L.
- Affiliations
- Boston Children's Hospital (US)
- ORCID
- Venue
- Circulation
- Published
- 2007-06-12
- Volume
- 115
- Issue
- 23
- Pages
- 2995-3014
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2617245041
- Cited by
- 818
- References
- 232
- Citations by year
- 2026: 21 · 2025: 26 · 2024: 50 · 2023: 42 · 2022: 52 · 2021: 42 · 2020: 50 · 2019: 48 · 2018: 52 · 2017: 38 · 2016: 43 · 2015: 61 · 2014: 55 · 2013: 52 · 2012: 48
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- congenital heart disease, modifiable risk factors, fetal heart development, periconceptional folic acid supplementation, maternal rubella infection, phenylketonuria, pregestational diabetes, thalidomide, retinoids, prenatal drug exposure, environmental exposure, paternal exposure, pregnancy monitoring
- MeSH terms
- Female, Fetal Diseases, Heart Defects, Congenital, Humans, Pregnancy, Risk Factors, Cardiovascular Abnormalities, Maternal Exposure, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review