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No association between low density lipoprotein receptor genetic variants and Alzheimer's disease risk
Abstract
A number of studies suggest that brain cholesterol metabolism may play a role in Alzheimer's disease (AD) development, probably through modulation of amyloid beta production. The discovery that apolipoprotein E (APOE) epsilon4 allele is a risk factor for sporadic AD raises the possibility that the receptors to which APOE binds on the surface of neurons are also involved in the neurodegenerative process. To evaluate the relationship between low density lipoprotein receptor (LDLR) genetic variant and AD, independently or in concert with the APOE epsilon4 allele, we examined three LDLR polymorphisms located in exons 8 (rs 11669576), 10 (rs 5930), and 13 (rs 5925), in a large group of 322 Spanish AD patients and 314 controls. The current study does not demonstrate an association between LDLR genotypes or haplotypes and AD, neither in the total sample nor when the populations were stratified for the presence or absence of the APOE epsilon4 allele.
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Others could not replicate the earlier studies and a meta-analysis of previously reported case-control data failed to detect any significant summary odds ratios.
“However, others could not replicate the earlier studies and a meta-analysis of the previously reported case-control data failed to detect any significant summary odds ratios (Bertram et al., 2007a; Rodriguez et al., 2006).”
From Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance (2009) · cites this paper as Rodriguez et al., 2006
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References 13 · Cited by 10
Research works printed but not linked: 13
- 10.1194/jlr.R300017-JLR200 · DOI
- 10.1136/jmg.2004.024968 · DOI · Paper page
- 10.1097/00041433-200104000-00003 · DOI · Paper page
- 10.1016/j.neurobiolaging.2004.09.001 · DOI · Paper page
- 10.1016/S0896-6273(01)00234-3 · DOI
- 10.1016/S0304-3940(97)13381-X · DOI
- 10.1161/01.ATV.0000094963.07902.FB · DOI · Paper page
- 10.1212/WNL.34.7.939 · DOI · Paper page
- 10.1385/MN:27:1:1 · DOI
- 10.1016/S1471-4914(03)00007-8 · DOI · Paper page
- 10.1038/nn0403-345 · DOI · Paper page
- 10.1097/00041444-200109000-00002 · DOI · Paper page
- 10.1002/jnr.10348 · DOI
Metadata
- Authors
- Rodríguez, E., Mateo, I., Llorca, J., Sánchez‐Quintana, C., Infante, J., Berciano, J., & Combarros, O.
- Affiliations
- Universidad de Cantabria (ES)
- Corresponding author
- Combarros, Onofre
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2006-06
- Volume
- 141B
- Issue
- 5
- Pages
- 541-543
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W2069815951
- Cited by
- 10
- References
- 13
- Citations by year
- 2019: 1 · 2018: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- Alzheimer's disease, LDL receptor, APOE ε4, genetic association, brain cholesterol metabolism, amyloid-beta, Spanish population
- MeSH terms
- Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Exons, Female, Gene Frequency, Genotype, Haplotypes, Humans, Male, Middle Aged, Polymorphism, Genetic, Receptors, LDL, Risk Factors, Genetic Predisposition to Disease
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