EGR3 as a potential susceptibility gene for schizophrenia in Korea
Abstract
Early growth response (EGR) genes play critical roles in signal transduction in the brain, which is involved in neuronal activation, brain development, and synaptic plasticity. EGR genes, including EGR2, EGR3, and EGR4, showed significant association with schizophrenia in Japanese schizophrenic pedigrees. In particular, EGR3, which resides at the chromosomal location 8p21.3, was suggested to be a potential susceptibility gene in schizophrenia based on a study of Japanese cases. However, this requires further replication with an independent sample set. We investigated the association of the EGR3 and EGR2 genes, which were suggested as potential susceptibility genes for schizophrenia supported by both genetic association and postmortem brain expression studies, with schizophrenia in Korean patients. Along with 350 healthy individuals, 244 schizophrenic patients were analyzed. Among the four examined single‐nucleotide polymorphisms (SNPs) of EGR3 (rs1008949, rs7009708, rs35201266, and rs3750192), SNP rs35201266 in intron 1 of the EGR3 gene showed a significant association with schizophrenia (P = 0.0008, χ2 = 11.156, OR = 1.493), which withstands multiple testing correction. In addition, the “T‐G‐C‐G” haplotype of EGR3 was under‐represented in the patients with schizophrenia (P = 0.0073, χ2 = 7.188, OR = 0.697). However, an association between the SNPs of EGR2 (rs2295814 and rs2297488) and schizophrenia was not found. These findings are consistent with the previous genetic association of the EGR3 gene in Japanese cohorts, which is the first replication concerning the association of EGR3 with schizophrenia in an independent cohort. Taken together, EGR3 could be suggested as a compelling susceptibility gene in schizophrenia. © 2010 Wiley‐Liss, Inc.
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Egr3 has been implicated in both schizophrenia and circadian organization.
“Another gene that has been implicated in both SZ and circadian organization is immediate early gene growth response 3 (Egr3)162,165–168.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [167]
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- Authors
- Kim, S. H., Song, J. Y., Joo, E., Lee, K. Y., Ahn, Y. M., & Kim, Y. S.
- Affiliations
- Seoul National University (KR)
- Eulji University (KR)
- Corresponding author
- Kim, Yong Sik
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2010-08-04
- Volume
- 153B
- Issue
- 7
- Pages
- 1355-1360
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W2028268440
- Cited by
- 41
- References
- 49
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 5 · 2018: 4 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 6
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- EGR3, EGR2, schizophrenia, genetic susceptibility, single nucleotide polymorphisms, haplotype association, Korean patients, replication study
- MeSH terms
- Haplotypes, Humans, Korea, Schizophrenia, Down-Regulation, Gene Expression, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Early Growth Response Protein 2, Early Growth Response Protein 3, Genetic Association Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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