Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes
Abstract
Innate/adaptive immune responses and transcript profiles of peripheral blood monocytes were studied in ASD children who exhibit fluctuating behavioral symptoms following infection and other immune insults (ASD/Inf, N=30). The ASD/Inf children with persistent gastrointestinal symptoms (ASD/Inf+GI, N=19), revealed less production of proinflammatory and counter-regulatory cytokines with stimuli of innate immunity and marked changes in transcript profiles of monocytes as compared to ASD/no-Inf (N=28) and normal (N=26) controls. This included a 4-5 fold up-regulation of chemokines (CCL2 and CCL7), consistent with the production of more CCL2 by ASD/Inf+GI cells. These results indicate dysregulated innate immune defense in the ASD/Inf+GI children, rendering them more vulnerable to common microbial infection/dysbiosis and possibly subsequent behavioral changes.
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ASD patients with comorbid GI dysfunction exhibit altered innate immune responses and distinct pro-inflammatory transcriptional profiles compared to ASD patients without GI dysfunction.
“ASD patients with comorbid GI dysfunction specifically exhibit altered innate immune responses and distinct pro-inflammatory transcriptional profiles compared to ASD patients without GI dysfunction [72, 73].”
From Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders (2018) · cites this paper as [73]
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- Authors
- Jyonouchi, H., Geng, L., Streck, D. L., & Toruner, G. A.
- Affiliations
- Rutgers New Jersey Medical School (US)
- Corresponding author
- Jyonouchi, Harumi
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 238
- Issue
- 1-2
- Pages
- 73-80
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2075746515
- Cited by
- 67
- References
- 49
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 8 · 2016: 1 · 2015: 6 · 2014: 9 · 2013: 15 · 2012: 6
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Jonty Foundation, St. Paul, MN
- Autism Research Institute, San Diego, CA
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- autism spectrum disorder, chronic gastrointestinal symptoms, innate immunity, peripheral blood monocytes, transcriptome, cytokines, chemokines, MCP-1, CCL7, infection, behavioral symptoms, dysbiosis, children
- MeSH terms
- Adolescent, Adult, Behavioral Symptoms, Child, Child Development Disorders, Pervasive, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Gastrointestinal Diseases, Humans, Immunity, Innate, Leukocytes, Mononuclear, Male, Middle Aged, RNA, Messenger, Transcription Factors, Cytokines
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