Nicotine dependence and psychosis in Bipolar disorder and Schizoaffective disorder, Bipolar type
Open accessAbstract
Patients with Bipolar disorder smoke more than the general population. Smoking negatively impacts mortality and clinical course in Bipolar disorder patients. Prior studies have shown contradictory results regarding the impact of psychosis on smoking behavior in Bipolar disorder. We analyzed a large sample of Bipolar disorder and Schizoaffective disorder, Bipolar Type patients and predicted those with a history of psychosis would be more likely to be nicotine dependent. Data from subjects and controls were collected from the Genomic Psychiatry Cohort (GPC). Subjects were diagnosed with Bipolar disorder without psychosis (N = 610), Bipolar disorder with psychosis (N = 1544). Participants were classified with or without nicotine dependence. Diagnostic groups were compared to controls (N = 10065) using logistic regression. Among smokers (N = 6157), those with Bipolar disorder had an increased risk of nicotine dependence (OR = 2.5; P < 0.0001). Patients with Bipolar disorder with psychosis were more likely to be dependent than Bipolar disorder patients without psychosis (OR = 1.3; P = 0.03). Schizoaffective disorder, Bipolar Type patients had more risk of nicotine dependence when compared to Bipolar disorder patients with or without psychosis (OR = 1.2; P = 0.02). Bipolar disorder patients experiencing more severity of psychosis have more risk of nicotine dependence. © 2015 Wiley Periodicals, Inc.
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People with bipolar disorder with psychosis were at higher risk to be addicted than people with bipolar disorder and no psychosis (OR = 1.3).
“People with BD with psychosis were on higher risk to be addicted than people with BD and no psychosis (OR = 1.3).”
From The detrimental effects of smoking on the course and outcome in adults with bipolar disorder—A narrative review (2023) · cites this paper as [23]
The Results report that, among smokers with bipolar disorder, those with psychosis had higher odds of nicotine dependence than those without psychosis (OR=1.3; p=0.03). The citing sentence omits the restriction to smokers and says “addicted” without specifying nicotine, so it is broader than the reported finding. (LLM, conf=0.84)
Experimental — accuracy not yet measuredAmong smokers, those with bipolar disorder had a significantly increased risk of nicotine dependence (OR = 2.5).
“Analysis of the large database of the Genomic Psychiatry Cohort (GPC) revealed that among smokers, those with BD had a significantly increased risk of ND (OR = 2.5).”
From The detrimental effects of smoking on the course and outcome in adults with bipolar disorder—A narrative review (2023) · cites this paper as [23]
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- Authors
- Estrada, E., Hartz, S. M., Tran, J., Hilty, D. M., Sklar, P., Smoller, J. W., Genomic Psychiatry Cohort Consortium, Pato, M. T., & Pato, C. N.
- Affiliations
- University of Southern California (US)
- Washington University in St. Louis (US)
- Icahn School of Medicine at Mount Sinai (US)
- Harvard University (US)
- Corresponding author
- Pato, Michele T.
- ORCID
- Venue
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2015-10-15
- Volume
- 171
- Issue
- 4
- Pages
- 521-524
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- PMC
- PMC4950843
- OpenAlex
- W2181556265
- Cited by
- 14
- References
- 24
- Citations by year
- 2026: 3 · 2025: 3 · 2023: 1 · 2022: 3 · 2018: 2 · 2017: 1 · 2016: 1
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (R01 MH085542, R01 MH085548)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- nicotine dependence, smoking, bipolar disorder, psychosis, psychosis severity, psychiatric comorbidity
- MeSH terms
- Adult, Bipolar Disorder, Female, Humans, Male, Tobacco Use Disorder, Logistic Models
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