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Genetics in psychiatry: Methods, clinical applications and future perspectives

Fabbri, C. (2022) · Psychiatry and Clinical Neurosciences Reports · doi:10.1002/pcn5.6 · Cited by 22 · see citing works

A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity

Baltramonaityte, V., Pingault, J., Cecil, C. A. M., Choudhary, P., Järvelin, M., Penninx, B. W. J. H., Felix, J. F., Sebert, S. P., Milaneschi, Y., & Walton, E. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010508 · Cited by 19 · see citing works

Association of mood disorder with cardiometabolic multimorbidity trajectory and life expectancy, a prospective cohort study

Yin, J., Ma, T., Li, J., Zhang, G., Cheng, X., & Bai, Y. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.06.003 · Cited by 17 · see citing works

Current State of Fluid Lipid Biomarkers for Personalized Diagnostics and Therapeutics in Schizophrenia Spectrum Disorders and Related Psychoses: A Narrative Review

Couttas, T. A., Jieu, B., Rohleder, C., & Leweke, F. M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.885904 · Cited by 17 · see citing works

The shared genetic architecture of modifiable risk for Alzheimer's disease: a genomic structural equation modelling study

Foote, I. F., Jacobs, B. M., Mathlin, G., Watson, C. J., Bothongo, P. L., Waters, S., Dobson, R., Noyce, A. J., Bhui, K. S., Korszun, A., et al. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.02.016 · Cited by 16 · see citing works

Genetic and Environmental Contribution to the Co-Occurrence of Endocrine-Metabolic Disorders and Depression: A Nationwide Swedish Study of Siblings

Leone, M., Kuja‐Halkola, R., Levál, A., Butwicka, A., Skov, J., Zhang, R., Liu, S., Larsson, H., & Bergen, S. E. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.21090954 · Cited by 15 · see citing works

Overweight in mood disorders: Effects on morbidity and treatment response

Miola, A., Pinna, M., Manchia, M., Tondo, L., & Baldessarini, R. J. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.10.032 · Cited by 13 · see citing works

Multimodal fusion of brain imaging and proteomics reveals a brain–body pathway linking depression and metabolic dysfunction

Lian, Z., Liu, Z., Fan, H., Wang, J., Zhang, K., Liu, Y., Kuang, N., Yu, G., Cheng, W., Becker, B., et al. (2026) · Psychological Medicine · doi:10.1017/s003329172610436x · Cited by 15 · see citing works

Exploring the genetic correlation of cardiovascular diseases and mood disorders in the UK Biobank

Chen, C., Liao, W.-Y., Chattopadhyay, A. S., & Lu, T. (2023) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796023000252 · Cited by 11 · see citing works

Late-onset depression is associated to age-related central auditory processing disorder in an older population in Southern Italy

Lozupone, M., Sardone, R., Donghia, R., D’Urso, F., Piccininni, C., Battista, P., Gioia, I. D., Resta, E., Castellana, F., Lampignano, L., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00290-1 · Cited by 10 · see citing works

The impact of major depressive disorder on glycaemic control in type 2 diabetes: a longitudinal cohort study using UK Biobank primary care records

Gillett, A. C., Hagenaars, S. P., Handley, D., Casanova, F., Young, K., Green, H., Lewis, C. M., & Tyrrell, J. (2024) · BMC Medicine · doi:10.1186/s12916-024-03425-9 · Cited by 11 · see citing works

Anxiety disorder, depression and coronary artery disease: associations and modification by genetic susceptibility

Nakada, S., Ward, J., Strawbridge, R. J., Welsh, P. I., Celis-Morales, C. A., Ho, F. K. W., & Pell, J. P. (2025) · BMC Medicine · doi:10.1186/s12916-025-03915-4 · Cited by 9 · see citing works

Stratification of individuals with lifetime depression and low wellbeing in the UK Biobank

Fabbri, C., Mutz, J., Lewis, C. M., & Serretti, A. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.07.023 · Cited by 7 · see citing works

A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease

Banerjee, P., Chau, K. M., Kotla, S., Davis, E. L., Turcios, E. B., Li, S., Zhang, P., Wang, G., Kolluru, G. K., Jain, A., et al. (2024) · Current Atherosclerosis Reports · doi:10.1007/s11883-024-01223-5 · Cited by 7 · see citing works

Distinct genomic signatures and modifiable risk factors underly the comorbidity between major depressive disorder and cardiovascular diseasePreprint

Bergstedt, J., Pasman, J. A., Ma, Z., Harder, A., Yao, S., Parker, N., Treur, J. L., Smit, D. J. A., Frei, O., Shadrin, A. A., et al. (2023) · medRxiv · doi:10.1101/2023.09.01.23294931 · Cited by 7 · see citing works

Association between cholesterol and response to escitalopram and nortriptyline in patients with major depression: Study combining clinical and register-based information

Gasse, C., Otte, C., Gold, S. M., Elfving, B., Mors, O. N., & Köhler‐Forsberg, O. (2022) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2022.100057 · Cited by 5 · see citing works

Harnessing the Power of Population Cohorts to Study the Relationship Between Endocrine-Metabolic Disorders and Depression

Jespersen, A., Yılmaz, Z., & Vilhjálmsson, B. J. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20220798 · Cited by 5 · see citing works

Large-scale evidence of a general disease (‘d’) factor accounting for both mental and physical health disorders in different age groups

Hongyi, S., Carr, H., Garcia‐Argibay, M., Cortese, S., Solmi, M., Golm, D., & Brandt, V. C. (2025) · Psychological Medicine · doi:10.1017/s0033291725000522 · Cited by 4 · see citing works

A prospective registry analysis of psychosocial and metabolic health between women with and without metabolic syndrome after a complicated pregnancy

Aldridge, E., Schubert, K. O., Pathirana, M. M., Sierp, S., Leemaqz, S., Roberts, C. T., Dekker, G., & Arstall, M. A. (2022) · BMC Women s Health · doi:10.1186/s12905-022-02035-y · Cited by 4 · see citing works

Nonlinear association between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR), residual cholesterol (RC), and late-life depression: the potential mediating role of cardiovascular metabolic diseases in the elderly population of China

Gu, C., Long, Z., Fang, Z., Wu, L., Yang, F., & Luo, W. (2026) · BMC Geriatrics · doi:10.1186/s12877-026-07029-1 · Cited by 3 · see citing works

Genetic Comorbidity of Depression and Somatic Diseases: Rationale Study Design in a Population Cohort Using Polygenic Risk Scores

Kibitov, A. O., Mazo, G. E., Kasyanov, E. D., Gorbunova, A. P., Rukavishnikov, G. V., & Незнанов, Н. Г. (2024) · Psikhiatriya · doi:10.30629/2618-6667-2024-22-2-54-65 · Cited by 3 · see citing works

Brain-derived neurotrophic factor in the pathogenesis of comorbid coronary artery disease and depression: a review

Kytikovа, O. Y., Antonyuk, M. V., Novgorodtseva, T. P., & Gvozdenko, T. A. (2024) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2024-5945 · Cited by 3 · see citing works

Increased metabolic risk in young people with emerging mood disorders and circadian rhythm disruption.Preprint

McKenna, S., Shin, M., Park, S. H., Nichles, A., Zmicerevska, N., Crouse, J. J., Janiszewski, C. M. S., Park, M., Phung, E., Iorfino, F., et al. (2024) · doi:10.33774/coe-2024-dt89c · Cited by 3 · see citing works

Immune DNA methylation in depression: cross-sectional and longitudinal study

Herrera-Rivero, M., Nauck, M., Berger, K., & Baune, B. T. (2025) · BJPsych Open · doi:10.1192/bjo.2025.10065 · Cited by 2 · see citing works

Genetic overlap and shared risk loci between autism spectrum disorder and cardiometabolic traits

Muntané, G., Shadrin, A. A., Guardiola-Ripoll, M., O’Connell, K. S., Frei, O., Nærland, T., Vilella, E., & Andreassen, O. A. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03563-x · Cited by 2 · see citing works

Genetic architecture of DCC and influence on psychological, psychiatric and cardiometabolic traits in multiple ancestry groups in UK Biobank

Forsyth, L., Aman, A., Cullen, B., Graham, N., Lyall, D. M., Lyall, L. M., Pell, J. P., Ward, J., Smıth, D. J., & Strawbridge, R. J. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.07.052 · Cited by 2 · see citing works

Online phenotypes of depression symptoms are associated with polygenic risk scores of somatic diseases in a population-based cohort

Kibitov, A. O., Rakitko, A., Kasyanov, E. D., Rukavishnikov, G. V., Shumskaia, D. S., Ilinsky, V. V., Незнанов, Н. Г., & Mazo, G. E. (2024) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2024124111122 · Cited by 2 · see citing works

Investigating Shared Cardiovascular Factors and Genetic Overlap of Pregnancy-Related Disorders, Major Depressive Disorder, and Alzheimer’s Disease

Oppenheimer, H., Shadrin, A. A., Andersen, J. Ø., Schindler, L. S., Crestol, A., Andreassen, O. A., Westlye, L. T., de Lange, A. G., van der Meer, D., & Barth, C. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.09.018 · Cited by 3 · see citing works

Pharmacogenomic scores in psychiatry: Systematic review of existing evidencePreprint

Sharew, N. T., Clark, S. R., Schubert, K. O., & Amare, A. T. (2024) · medRxiv · doi:10.1101/2024.04.05.24305376 · Cited by 2 · see citing works

Neurodevelopmental copy number variants increase risk of internalising and cardiometabolic multimorbidity: findings from UK BiobankPreprint

Katzourou, I. K., Barroso, I., Clayton, J., Khandaker, G. M., Stow, D., Timpson, N. J., Tsang, R. S. M., Underwood, J. F. G., Wood, M. L., Kirov, G., et al. (2025) · medRxiv · doi:10.1101/2025.05.13.25326577 · Cited by 2 · see citing works

Combining polygenic risk scores to understand genetic liability to physical-mental health multimorbidity in UK Biobank

Stow, D., Tsang, R. S. M., Katzourou, I., Underwood, J. F. G., Holmans, P. A., Barroso, I., Martin, H., van den Bree, M. V. D., Finer, S., & Timpson, N. (2026) · Human Molecular Genetics · doi:10.1093/hmg/ddag012

Neurodevelopmental copy-number variants increase risk of internalizing and cardiometabolic multimorbidity: Findings from the UK Biobank

Katzourou, I. K., van den Bree, M. B. M., George, K., Owen, M. J., Walters, J. T., Holmans, P., Lynch, J., Katzourou, I. K., Underwood, J. F. J., van Heel, D. A., et al. (2026) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2026.02.021 · Cited by 3 · see citing works

The impact of major depressive disorder on glycaemic control in type 2 diabetes: a longitudinal cohort study using UK Biobank primary care recordsPreprint

Gillett, A. C., Hagenaars, S. P., Handley, D., Casanova, F., Young, K., Green, H., Lewis, C. M., & Tyrrell, J. (2022) · medRxiv · doi:10.1101/2022.01.13.22269229

Genetic architecture of DCC and influence on psychological, psychiatric and cardiometabolic traits in multiple ancestry groups in UK BiobankPreprint

Strawbridge, R. J., Forsyth, L., Cullen, B., Graham, N., Lyall, D. M., Lyall, L. M., Pell, J. P., Ward, J., & Smıth, D. J. (2022) · Research Square · doi:10.21203/rs.3.rs-2158925/v1

Homeostatic inflammation in the placenta is protective against adult cardiovascular and depressive outcomesPreprint

Fitzgerald, E., Shen, M., Yong, H. E. J., Wang, Z., Pokhvisneva, I., Patel, S. H., O’Toole, N., Chan, S., Chong, Y. S., Chen, H., et al. (2023) · medRxiv · doi:10.1101/2023.02.20.23286171

Unraveling the Genetic Interplay and Therapeutic Potentials between Major Depressive Disorder and Metabolic Syndrome: Multi-Ancestry and Multi-Trait Genome-Wide Association AnalysesPreprint

Feng, Y., Jia, N., Gu, X., Xiao, C., & Shen, J. (2024) · Research Square · doi:10.21203/rs.3.rs-4193051/v1

Clinical features of overweight in acute-phase hospitalised major depressive disorder with comorbid anxiety: a cross-sectional study

Zhang, H., Wang, J., Zhu, W., & Liu, X. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-087640

Additional file 1 of The impact of major depressive disorder on glycaemic control in type 2 diabetes: a longitudinal cohort study using UK Biobank primary care records

Gillett, A. C., Hagenaars, S. P., Handley, D., Casanova, F., Young, K. G., Green, H., Lewis, C. M., & Tyrrell, J. (2024) · Figshare · doi:10.6084/m9.figshare.26726860

Additional file 3 of The impact of major depressive disorder on glycaemic control in type 2 diabetes: a longitudinal cohort study using UK Biobank primary care records

Gillett, A. C., Hagenaars, S. P., Handley, D., Casanova, F., Young, K. G., Green, H., Lewis, C. M., & Tyrrell, J. (2024) · Figshare · doi:10.6084/m9.figshare.26726866

Additional file 2 of The impact of major depressive disorder on glycaemic control in type 2 diabetes: a longitudinal cohort study using UK Biobank primary care records

Gillett, A. C., Hagenaars, S. P., Handley, D., Casanova, F., Young, K. G., Green, H., Lewis, C. M., & Tyrrell, J. (2024) · Figshare · doi:10.6084/m9.figshare.26726863

Additional file 1 of A prospective registry analysis of psychosocial and metabolic health between women with and without metabolic syndrome after a complicated pregnancy

Aldridge, E., Schubert, K. O., Pathirana, M. M., Sierp, S., Leemaqz, S., Roberts, C. T., Dekker, G., & Arstall, M. A. (2022) · Figshare · doi:10.6084/m9.figshare.21594074

Additional file 4 of The impact of major depressive disorder on glycaemic control in type 2 diabetes: a longitudinal cohort study using UK Biobank primary care records

Gillett, A. C., Hagenaars, S. P., Handley, D., Casanova, F., Young, K. G., Green, H., Lewis, C. M., & Tyrrell, J. (2024) · Figshare · doi:10.6084/m9.figshare.26726869

Unraveling the genetic interplay and therapeutic potentials between major depressive disorder and metabolic syndrome: multi-ancestry and multi-trait genome-wide association analyses

Feng, Y., Li, Y., Zhang, H., Xia, H., Lu, Y. F., Zhou, H., & Huang, P. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-07816-5

Early-life hallmarks of polygenic liability to adult internalizing-cardiometabolic multimorbidityPreprint

Tsang, R. S. M., Stow, D., Katzourou, I. K., van den Bree, M. B. M., Khandaker, G. M., & Timpson, N. J. (2026) · medRxiv · doi:10.64898/2026.05.01.26352146

Familial coaggregation and shared genetic loading of mental disorders and cardiovascular diseases

Chen, P.-C., Pan, Y., Lin, M.-C., Su, M.-H., Fan, C.-C., Wu, C.-S., & Wang, S.-H. (2026) · Psychological Medicine · doi:10.1017/s0033291725101724

Genetic perspectives on the comorbidity of anxiety and mood disorders with cardiovascular disease

de Geus, E. J. C., Treur, J. L., & Penninx, B. W. J. H. (2026) · Nature Cardiovascular Research · doi:10.1038/s44161-026-00822-6

Depression and Diabetes: Major Studies from Germany

Gäebel, W., Mukherjee, D., Müssig, K., Wölwer, W., & Philip, S. (2026) · Springer eBooks · doi:10.1007/978-981-92-2755-6_12

Genetic comorbidity between major depression and cardio-metabolic disease, stratified by age at onset of major depressionPreprint

Hagenaars, S., Coleman, J., Choi, S., Gaspar, H., Adams, M., Howard, D., Hodgson, K., Traylor, M., Air, T., Andlauer, T., et al. (2019) · bioRxiv · doi:10.1101/645077 · Cited by 1 · see citing works

Differential associations of various depression-related phenotypes with cardiometabolic risks: Identification of shared genetic factors and implications for drug repositioningPreprint

Wong, B. C., Chau, C. K., Ao, F., Mo, C., Wong, S., Wong, Y. H., & So, H. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/140590 · Cited by 2 · see citing works

Differential associations of depression‐related phenotypes with cardiometabolic risks: Polygenic analyses and exploring shared genetic variants and pathways

Wong, B. C., Chau, C. K., Ao, F., Mo, C., Wong, S., Wong, Y. H., & So, H. (2018) · Depression and Anxiety · doi:10.1002/da.22861 · Cited by 31 · see citing works

Genetic Overlap Between Depression and Cardiometabolic Disorders

Amare, A. T., Schubert, K. O., & Baune, B. T. (2016) · Springer eBooks · doi:10.1007/978-3-319-32480-7_15

Distinct genomic signatures and modifiable risk factors underly the comorbidity between major depressive disorder and cardiovascular diseasePreprint

Bergstedt, J., Pasman, J. A., Ma, Z., Harder, A., Yao, S., Parker, N., Treur, J. L., Smit, D. J. A., Frei, O., Shadrin, A. A., et al. (2023) · medRxiv · doi:10.1101/2023.09.01.23294931 · Cited by 7 · see citing works