Heritability and components of phenotypic expression in skin reflectance of Mestizos from the Peruvian lowlands
Abstract
Skin reflectance was measured on the inner arm and forehead of a sample of 209 Mestizos ranging in age from 2 to 64 years living in the town of Lamas in the Eastern peruvian Lowlands. The sample consisted of 43 father-son, 42 father-daughter, 62 mother-son, and 70 mother-daughter pairs. The sample also consisted of 57 brother-brother, 60 sister-sister and 139 brother-sister pairs. The reflectance measurements were made with a Photovolt Reflection Meter, model 670. Stepwise polynomial regression techniques were used to derive standardized residual values. Then using these residual values parent-offspring, sibling intraclass correlations and components of the phenotype expression of skin reflectance were calculated. The study indicates that 1) the parent-offspring and sibling correlation coefficients conformed with the theoretical correlations expected assuming polygenic inheritance; 2) the husband-wife correlations indicate a high degree of assortative mating for skin color, but despite this effect the parent-offspring and sibling correlation coefficients are lower that the values expected under the influence of autosomal genes; 3) estimates of heritability and components of phenotypic expression indicate that about 55% of the total variability in skin reflectance could be attributed to the influence of additive genetic factors; and 4) there is no evidence of X-linkage in the inheritance of skin color.
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Skin pigmentation is a polygenic quantitative trait with high heritability in humans.
“Epidemiological studies in humans show that skin pigmentation is a polygenic quantitative trait with high heritability, [8][9][10]”
From A Genomewide Association Study of Skin Pigmentation in a South Asian Population (2007) · cites this paper as [9]
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- Authors
- Frisancho, A. R., Wainwright, R., & Way, A.
- Affiliations
- University of Michigan (US)
- Texas Tech University (US)
- Venue
- American Journal of Physical Anthropology
- Publisher
- Wiley
- Published
- 1981-06
- Volume
- 55
- Issue
- 2
- Pages
- 203-208
- ISSN
- 0002-9483 (ISSN-L)
- 1096-8644
- OpenAlex
- W2094818406
- Cited by
- 34
- References
- 13
- Citations by year
- 2024: 1 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 1 · 2013: 3 · 2012: 2
- FWCI
- 0.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physical Anthropology (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Race, Genetics, and Society
- Keywords
- skin reflectance, skin color, heritability, phenotypic expression, additive genetic variance, polygenic inheritance, assortative mating, parent-offspring correlation, sibling correlation, X-linked inheritance, mestizo population
- MeSH terms
- Adolescent, Adult, Age Factors, Child, Child, Preschool, Female, Genetics, Population, Humans, Indians, South American, Male, Middle Aged, Peru, Phenotype, Sex Factors, Skin Pigmentation
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