Precision prevention of Alzheimer's and other dementias: Anticipating future needs in the control of risk factors and implementation of disease‐modifying therapies
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Empirical evidence suggests that a fair proportion of dementia cases are preventable, that some preventive actions can be taken immediately, and others may soon be implemented. Primary prevention may target cognitively normal persons with modifiable risk factors through lifestyle and multiple domain interventions (including general cardiovascular health). While the effect on individuals may be modest, it might have a large societal impact by decreasing overall dementia incidence by up to 35%. Secondary prevention will target cognitively normal persons at high risk of dementia due to Alzheimer's disease pathology with future anti-amyloid, anti-tau, or other drugs. This approach is likely to have major benefits to both individuals and society. Memory clinics will need structural and functional changes to adapt to novel technologies and increased patients' demands, and brand-new services may need to be developed with specific skills on risk profiling, risk communication, and personalized risk reduction plans.
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Dementia research has predominantly focused on cure or care, much less so on the prevention of dementia.
“Dementia research has predominantly focused on cure or care, much less so on the prevention of dementia.3”
From Dementia prevention and the GP’s role: a qualitative interview study (2024) · cites this paper as [3]
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- Authors
- Frisoni, G. B., Molinuevo, J. L., Altomare, D., Carrera, E., Barkhof, F., Berkhof, J., Delrieu, J., Dubois, B., Kivipelto, M., Nordberg, A., Schott, J. M., van der Flier, W. M., Vellas, B., Jessen, F., Scheltens, P., & Ritchie, C.
- Affiliations
- University of Geneva (CH)
- Barcelonaβeta Brain Research Center Pasqual Maragall Foundation Barcelona Spain
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Inserm (FR)
- Karolinska University Hospital (SE)
- UCL Queen Square Institute of Neurology (GB)
- Department of Epidemiology and Biostatistics Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam the Netherlands
- University of Cologne (DE)
- University of Edinburgh (GB)
- Corresponding author
- Frisoni, Giovanni B.
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2020-08-20
- Volume
- 16
- Issue
- 10
- Pages
- 1457-1468
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W3076113041
- Cited by
- 78
- References
- 46
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 20 · 2023: 11 · 2022: 9 · 2021: 19
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (acceptedVersion)
- HAL (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- DZNE Pub (submittedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- EU Joint Programme – Neurodegenerative Disease Research
- Health~Holland
- National Institute for Health and Care Research (115952)
- ZonMw (733051102)
- University College London Hospitals NHS Foundation Trust
- Medical Research Council (MR/L023784/1)
- Engineering and Physical Sciences Research Council (EP/J020990/1)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- dementia prevention, Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Dementia, Humans, Primary Prevention, Risk Factors, Risk Reduction Behavior, Secondary Prevention
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