Modulation of use‐dependent plasticity by d‐amphetamine
Abstract
Use‐dependent plasticity, thought to contribute to functional recovery after brain injury, is elicited by motor training. The purpose of this study was to determine if administration of d‐amphetamine facilitates the effects of motor training on use‐dependent plasticity. Healthy human volunteers underwent a training period of voluntary thumb movements under the effects of placebo or d‐amphetamine in different sessions in a randomized double‐blind, counterbalanced design. Previous work in a drug‐naive condition showed that such training causes changes in the direction of thumb movements evoked by transcranial magnetic stimulation and in transcranial magnetic stimulation‐evoked electromyographic responses. The endpoint measure of the study was the magnitude of training‐induced changes in transcranial magnetic stimulation‐evoked kinematic and electromyographic responses in the d‐amphetamine and in the placebo conditions. Motor training resulted in increased magnitude, faster development and longer lasting duration of use‐dependent plasticity under d‐amphetamine compared to the placebo session. These results document a facilitatory effect of d‐amphetamine on use‐dependent plasticity, a possible mechanism mediating the beneficial effect of this drug on functional recovery after cortical lesions.
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Use-dependent plasticity rests on neuromodulatory transmitter function of the sort that may encode precision.
“Interestingly, this use-dependent plasticity rests on neuromodulatory transmitter function (Bütefisch et al. 2002) of the sort that may encode precision (Friston 2008).”
From Action and behavior: a free-energy formulation (2010) · cites this paper as Bütefisch et al. 2002
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Self-citationKinematic specificity of cortical reorganization associated with motor training
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“One recent study showed that dAMP can enhance use-dependent plasticity in human motor cortex (Bütefisch et al., 2002).”
BackgroundSelf-citationSawaki, L., Butler, A. J., Leng, X., Wassenaar, P., Mohammad, Y., Blanton, S., Sathian, K., Nichols-Larsen, D., Wolf, S., Good, D., et al. (2014) · NeuroRehabilitation (Reading, MA) · doi:10.3233/nre-141132 · Cited by 45
“It is known that several drugs could exert beneficial or detrimental effects on motor recovery(Boroojerdi et al., 2001, Butefisch et al., 2002, Goldstein, 1990, Goldstein and Davis, 1990, Sawaki et al., 2002, Sawaki et al., 2003a, Ziemann et al., 1999).”
BackgroundSelf-citationNeurobiological bases of rehabilitation
Bütefisch, C. (2006) · Neurological Sciences · doi:10.1007/s10072-006-0540-z · Cited by 45 · see citing works
Self-citationSSRI and Motor Recovery in Stroke: Reestablishment of Inhibitory Neural Network Tonus
Pinto, C. B., Vélez, F. G. S., Lopes, F., Piza, P. V. D. T., Dipietro, L., Wang, Q. M., Mazwi, N., Camargo, E. C., Black‐Schaffer, R. M., & Fregni, F. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00637 · Cited by 43 · see citing works
“Some of these pharmacological candidates are SSRIs (Pariente et al., 2001; Chollet et al., 2011), dopamine agonist (Scheidtmann et al., 2001), amphetamines (Bütefisch et al., 2002; Sawaki et al., 2002b) and cholinergic substances (ACR) (Sawaki et al., 2002a; Meintzschel and Ziemann, 2006).”
BackgroundPhillips, J., Devier, D. J., & Feeney, D. M. (2003) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-200307000-00005 · Cited by 42 · see citing works
Karim, A., Schüler, A., Hegner, Y. L., Friedel, E., & Godde, B. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.9.1577 · Cited by 40 · see citing works
“So far it has been demonstrated in neuropharmacological investigations that excitabilityenhancing pharmacological agents, such as amphetamine, improve use-dependent plasticity (Bütefisch et al., 2002), whereas g-aminobutyric acid agonists diminish it (Blin et al., 2001).”
BackgroundAmphetamine enhances training‐induced motor cortex plasticity
Tegenthoff, M., Cornelius, B., Pleger, B., Malin, J., & Schwenkreis, P. (2004) · Acta Neurologica Scandinavica · doi:10.1046/j.1600-0404.2003.00235.x · Cited by 38 · see citing works
“The results therefore suggest that amphetamine is able to enhance training-induced motor cortex plasticity, a finding which is also supported by recent studies using a different TMSand motor-training paradigm (19, 20).”
BackgroundResultEffect of an α1-adrenergic blocker on plasticity elicited by motor training
Sawaki, L., Werhahn, K., Barco, R., Kopylev, L., & Cohen, L. (2003) · Experimental Brain Research · doi:10.1007/s00221-002-1328-x · Cited by 38 · see citing works
“In the last few years, new strategies were developed to enhance processes (Butefisch et al. 2002; Hovda et al. 1989; Walker-Batson et al. 2001).”
BackgroundSelf-citationSchwenkreis, P., Witscher, K., Pleger, B., Malin, J., & Tegenthoff, M. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-35 · Cited by 37 · see citing works
“Similar effects of GABAA agonists, NMDA antagonists and amphetamine were reported in series of studies using different paradigms to study training-induced motor cortex plasticity by TMS [14-16], and coactivation-induced plasticity in the primary somatosensory cortex [17-19].”
BackgroundGuidelines for Quality Management of Apallic Syndrome / Vegetative State
Wild, K., Gerstenbrand, F., Dolce, G., Binder, H., Vos, P., Saltuari, L., Alekseenko, Y., Formisano, R., Ritz, A., Ortega-Suhrkamp, E., et al. (2007) · European Journal of Trauma and Emergency Surgery · doi:10.1007/s00068-007-6138-1 · Cited by 36
Amphetamine promotes task-dependent recovery following focal cortical ischaemic lesions in the rat.
Gilmour, G., Iversen, S., O'Neill, M. F., O'Neill, M. J., Ward, M., & Bannerman, D. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.06.027 · Cited by 36 · see citing works
Dexamphetamine treatment in stroke
Long, D., & Young, J. (2003) · QJM · doi:10.1093/qjmed/hcg113 · Cited by 32 · see citing works
Sprigg, N., Willmot, M. R., Gray, L. J., Sunderland, A., Pomeroy, V. M., Walker, M. F., & Bath, P. M. (2007) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002205 · Cited by 37 · see citing works
Back to the future: rehabilitation of children after brain injury
Forsyth, R. (2010) · Archives of Disease in Childhood · doi:10.1136/adc.2009.161083 · Cited by 34 · see citing works
Korchounov, A., Ilic, T. V., & Ziemann, U. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0523-5 · Cited by 36 · see citing works
“Disinhibition or enhanced responsiveness of the motor cortex to TMS facilitates practice-dependent plasticity (B€utefisch et al., 2000, 2002; Ziemann et al., 2001; Sawaki et al., 2002; Meintzschel and Ziemann, 2006).”
BackgroundTranslational Studies in Neurorehabilitation: From Bench to Bedside
Flöel, A., & Cohen, L. (2006) · Cognitive and Behavioral Neurology · doi:10.1097/00146965-200603000-00001 · Cited by 34 · see citing works
“In healthy humans, intake of a single oral dose of D-amphetamine can enhance MMF.(51) Motor training 1 hour after receiving a single oral dose of 10mg D-amphetamine resulted in increased magnitude, faster development, and longer-lasting duration of MMF relative to placebo.”
BackgroundSelf-citationKrutky, M. A., & Perreault, E. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00750.2007 · Cited by 33 · see citing works
“These include TMS applied during training (Butefisch et al. 2004) and pharmacologic agents given before training (Butefisch et al. 2002; Floel et al. 2005; Sawaki et al. 2002).”
BackgroundInfluentialSpeeding stroke recovery? A systematic review of amphetamine after stroke.
Sprigg, N., & Bath, P. (2009) · Journal of Neurological Sciences · doi:10.1016/j.jns.2009.04.040 · Cited by 32
“In healthy volunteers, amphetamine can modulate use dependent plasticity, as measured by task specific training performance and simultaneous transcranial magnetic stimulation evoked electromyographic responses [9].”
BackgroundPharmacological modulation of learning-induced plasticity in human auditory cortex
Thiel, C. (2007) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2007-253426 · Cited by 32 · see citing works
“In healthy humans it has been shown that amphetamine can facilitate plasticity induced by motor training (Butefisch et al., 2002; Tegenthoff et al., 2004) and language learning (Breitenstein et al., 2004).”
Alaverdashvili, M., Lim, D. H., & Whishaw, I. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05594.x · Cited by 32 · see citing works
“, 1998), and facilitation of long-term potentiation (Butefisch et al., 2002).”
BackgroundAtomoxetine enhances a short-term model of plasticity in humans.
Foster, D. J., Good, D., Fowlkes, A. M., & Sawaki, L. (2006) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2005.08.131 · Cited by 32 · see citing works
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Monoaminergic agonists for acute traumatic brain injury.
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Use-dependent plasticity of the human motor cortex in health and disease
Sawaki, L. (2005) · IEEE Engineering in Medicine and Biology Magazine · doi:10.1109/memb.2005.1384098 · Cited by 31
“have reported, in a double-blinded, randomized design, that 10 mg d-amphetamine resulted in faster induction and increased the magnitude and prolonged the duration of use-dependent plasticity measured by TMS [18].”
BackgroundMethodSelf-citationPowell, E. S., Carrico, C., Salyers, E., Westgate, P., & Sawaki, L. (2018) · NeuroRehabilitation (Reading, MA) · doi:10.3233/nre-172369 · Cited by 28 · see citing works
Self-citationExploring Motor Cortical Plasticity Using Transcranial Magnetic Stimulation in Humans
Ilić, T., & Ziemann, U. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1342.016 · Cited by 27 · see citing works
Martinsson, L., & Eksborg, S. (2004) · Drugs & Aging · doi:10.2165/00002512-200421020-00001 · Cited by 47 · see citing works
Thorstensen, J. R., Henderson, T. T., & Kavanagh, J. J. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109761 · Cited by 25 · see citing works
- Authors
- Bütefisch, C. M., Davis, B. C., Sawaki, L., Waldvogel, D., Classen, J., Kopylev, L., & Cohen, L. G.
- Affiliations
- National Institutes of Health (US)
- University of Rostock (DE)
- Corresponding author
- Cohen, Leonardo G.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2001-12-03
- Volume
- 51
- Issue
- 1
- Pages
- 59-68
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2085716451
- Cited by
- 182
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 3 · 2018: 3 · 2017: 7 · 2016: 5 · 2015: 4 · 2014: 9 · 2013: 4 · 2012: 5
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- OAM-NIH
- Humboldt Foundation
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- use-dependent plasticity, d-amphetamine, motor training, functional recovery after brain injury, cortical lesions, transcranial magnetic stimulation, electromyographic response, kinematic response, thumb movement
- MeSH terms
- Adult, Central Nervous System Stimulants, Brain Injuries, Conditioning, Psychological, Dextroamphetamine, Double-Blind Method, Electric Stimulation, Female, Humans, Magnetics, Male, Movement, Neuronal Plasticity, Thumb, Evoked Potentials, Motor
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