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Increased HTLV‐I proviral load and preferential expansion of HTLV‐I tax‐specific CD8+ T cells in cerebrospinal fluid from patients with HAM/TSP
Abstract
To date, high human T‐cell lymphotropic virus type I proviral load in patients with human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis has been reported and is thought to be related to the pathogenesis of human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis. However, the proviral load in cerebrospinal fluid has not been well investigated. We measured human T‐cell lymphotropic virus type I proviral load in cerebrospinal fluid cells from human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis patients using real‐time quantitative polymerase chain reaction (TaqMan). Human T‐cell lymphotropic virus type I proviral load in cerebrospinal fluid cells were significantly higher than that of the matched peripheral blood mononuclear cells, and a high ratio of human T‐cell lymphotropic virus type I proviral load in cerebrospinal fluid cells to peripheral blood mononuclear cells were observed in patients with short duration of illness. Human T‐cell lymphotropic virus type I Tax‐specific CD8+ T cells, as detected by peptide‐loaded HLA tetramers, accumulated in cerebrospinal fluid compared with that in peripheral blood mononuclear cells, while the frequency of cytomegalovirus‐specific CD8+ T cells in cerebrospinal fluid was reduced. These observations suggest that accumulation of both human T‐cell lymphotropic virus type I‐infected cells and preferential expansion of human T‐cell lymphotropic virus type I‐specific CD8+ cells in cerebrospinal fluid may play a role in the pathogenesis of human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis.
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“It is associated with T cell transformation, resulting in the activation and proliferation of infected cells and HTLV-1 leukaemogenesis [46,68,215,216].”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [216]
In the citing paper
“There is strong evidence suggesting that increased HTLV-1 PVL in PBMCs is a potent risk factor for disease progression [216,271,272,273].”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [216]
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Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells
Johnson-Nauroth, J. M., Graber, J. J., Yao, K., Jacobson, S., & Calabresi, P. A. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.03.013 · Cited by 15
Self-citationAnalysis of a hepatitis B viral infection model with immune response delay
Pang, J., & Cui, J. (2016) · International Journal of Biomathematics · doi:10.1142/s1793524517500206 · Cited by 14
de Sá, K. S. G., Santana, B. B., Ferreira, T. C. D. S., Sousa, R. C. M., Caldas, C. A. M., Azevedo, V. N., Feitosa, R. N. M., Machado, L. F. A., Ishak, M. D. O. G., Ishak, R., et al. (2015) · Cytokine · doi:10.1016/j.cyto.2015.11.004 · Cited by 14
Gudo, E. S., Silva-Barbosa, S. D., Linhares‐Lacerda, L., Alves, M. R., Côrte‐Real, S., Bou‐Habib, D. C., & Savino, W. (2015) · Virology Journal · doi:10.1186/s12985-015-0398-x · Cited by 14
Tarokhian, H., Taghadosi, M., Rafatpanah, H., Rajaei, T., Azarpazhooh, M. R., Valizadeh, N., & Rezaee, S. A. (2016) · Virus Research · doi:10.1016/j.virusres.2016.11.009 · Cited by 14
Monocyte and Macrophage Functions in Oncogenic Viral Infections
Echevarria‐Lima, J., & Moles, R. (2024) · Viruses · doi:10.3390/v16101612 · Cited by 13
Martins, M. L., Carneiro‐Proietti, A. B. F., Nicolato, R., de Miranda, D. M., & Romanelli, L. C. F. (2018) · Journal of NeuroVirology · doi:10.1007/s13365-018-0632-6 · Cited by 13
Enose-Akahata, Y., Ngouth, N., Ohayon, J., Mandel, M., Chavin, J., Turner, T. J., & Jacobson, S. (2021) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000986 · Cited by 13
Self-citationQuantification of HTLV-I proviral load in experimentally infected rabbits
Zhao, T., Hague, B. F., Caudell, D. L., Simpson, R. J., & Kindt, T. J. (2005) · Retrovirology · doi:10.1186/1742-4690-2-34 · Cited by 13
Neurologic disease due to HTLV-1 infection
McKendall, R. R. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53488-0.00024-9 · Cited by 11
Identification and tracking of HTLV-1–infected T cell clones in virus-associated neurologic disease
Nozuma, S., Matsuura, E., Tanaka, M., Kodama, D., Matsuzaki, T., Yoshimura, A., Sakiyama, Y., Nakahata, S., Morishita, K., Enose‐Akahata, Y., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.167422 · Cited by 12
Ghezeldasht, S. A., Mosavat, A., & Rezaee, S. A. (2024) · Reviews in Medical Virology · doi:10.1002/rmv.2567 · Cited by 12
Mirsaliotis, A., Lamb, D., & Brighty, D. W. (2008) · Journal of Virology · doi:10.1128/jvi.02458-07 · Cited by 11
T cell receptor repertoire analysis in HTLV-1-associated diseases
Clauze, A., Enose‐Akahata, Y., & Jacobson, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.984274 · Cited by 10
Self-citationImmunopathogenic CSF TCR repertoire signatures in virus-associated neurologic disease
Nozuma, S., Enose‐Akahata, Y., Johnson, K. R., Monaco, M. C., Ngouth, N., ELKAHLOUN, A. G., Ohayon, J. M., Zhu, J., & Jacobson, S. (2021) · JCI Insight · doi:10.1172/jci.insight.144869 · Cited by 10
Self-citationNagai, M., Tsujii, T., Iwaki, H., Nishikawa, N., & Nomoto, M. (2013) · Internal Medicine · doi:10.2169/internalmedicine.52.0869 · Cited by 10
Self-citationGutowska, A., McKinnon, K. M., Sarkis, S., Doster, M. N., Bissa, M., Moles, R., Stamos, J. D., Rahman, M. A., Washington‐Parks, R., Davis, D. A., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.897264 · Cited by 9
Metadata
- Authors
- Nagai, M., Yamano, Y., Brennan, M. B., Mora, C. A., & Jacobson, S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Jacobson, Steven
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2001-11-29
- Volume
- 50
- Issue
- 6
- Pages
- 807-812
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2085122076
- Cited by
- 144
- References
- 24
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 5
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Keywords
- HTLV-1, HTLV-1-associated myelopathy/tropical spastic paraparesis, cerebrospinal fluid, proviral load, CD8+ T cells, HLA tetramers, cytomegalovirus-specific T cells, pathogenesis, neuroinflammation
- MeSH terms
- Adolescent, Adult, Cerebrospinal Fluid, Female, Flow Cytometry, Humans, Male, Middle Aged, Peptide Fragments, Human T-lymphotropic virus 1, Biomarkers, Paraparesis, Tropical Spastic, Gene Products, tax, CD8-Positive T-Lymphocytes, Viral Load
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