The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Increased HTLV‐I proviral load and preferential expansion of HTLV‐I tax‐specific CD8+ T cells in cerebrospinal fluid from patients with HAM/TSP
Abstract
To date, high human T‐cell lymphotropic virus type I proviral load in patients with human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis has been reported and is thought to be related to the pathogenesis of human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis. However, the proviral load in cerebrospinal fluid has not been well investigated. We measured human T‐cell lymphotropic virus type I proviral load in cerebrospinal fluid cells from human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis patients using real‐time quantitative polymerase chain reaction (TaqMan). Human T‐cell lymphotropic virus type I proviral load in cerebrospinal fluid cells were significantly higher than that of the matched peripheral blood mononuclear cells, and a high ratio of human T‐cell lymphotropic virus type I proviral load in cerebrospinal fluid cells to peripheral blood mononuclear cells were observed in patients with short duration of illness. Human T‐cell lymphotropic virus type I Tax‐specific CD8+ T cells, as detected by peptide‐loaded HLA tetramers, accumulated in cerebrospinal fluid compared with that in peripheral blood mononuclear cells, while the frequency of cytomegalovirus‐specific CD8+ T cells in cerebrospinal fluid was reduced. These observations suggest that accumulation of both human T‐cell lymphotropic virus type I‐infected cells and preferential expansion of human T‐cell lymphotropic virus type I‐specific CD8+ cells in cerebrospinal fluid may play a role in the pathogenesis of human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis.
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“It is associated with T cell transformation, resulting in the activation and proliferation of infected cells and HTLV-1 leukaemogenesis [46,68,215,216].”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [216]
In the citing paper
“There is strong evidence suggesting that increased HTLV-1 PVL in PBMCs is a potent risk factor for disease progression [216,271,272,273].”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [216]
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Metadata
- Authors
- Nagai, M., Yamano, Y., Brennan, M. B., Mora, C. A., & Jacobson, S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Jacobson, Steven
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2001-11-29
- Volume
- 50
- Issue
- 6
- Pages
- 807-812
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2085122076
- Cited by
- 144
- References
- 24
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 5
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Keywords
- HTLV-1, HTLV-1-associated myelopathy/tropical spastic paraparesis, cerebrospinal fluid, proviral load, CD8+ T cells, HLA tetramers, cytomegalovirus-specific T cells, pathogenesis, neuroinflammation
- MeSH terms
- Adolescent, Adult, Cerebrospinal Fluid, Female, Flow Cytometry, Humans, Male, Middle Aged, Peptide Fragments, Human T-lymphotropic virus 1, Biomarkers, Paraparesis, Tropical Spastic, Gene Products, tax, CD8-Positive T-Lymphocytes, Viral Load
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