The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Inhibition of autoimmune encephalomyelitis by a tetracycline
Abstract
We have explored the use of minocycline, a tetracycline with antiinflammatory properties, to treat chronic relapsing-remitting experimental allergic encephalomyelitis, an animal model of multiple sclerosis. Therapeutic treatment with minocycline dramatically suppresses ongoing disease activity and limits disease progression. Disease suppression is associated with immune deviation in the periphery and with suppression of the inflammatory cascade in the central nervous system. This association is demonstrated by inhibition of microglial activation and metalloproteinase-2 expression, which results in a concomitant decrease in inflammation and demyelination. As an established antiinflammatory drug with neuroprotective properties, minocycline may provide a novel therapeutic agent for relapsing-remitting multiple sclerosis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Additionally, MS patients that were treated with the antibiotic minocycline, a broad-spectrum tetracycline, have reduced rate of relapses and amelioration of several immunological parameters (such as IL-12p40, metalloproteinase-9, and soluble vascular cell adhesion molecule-1) (145, 146).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [146]
Citations
Cites
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases
Liblau, R., Singer, S. M., & McDevitt, H. O. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80068-9 · Cited by 1,111
Chen, M., Ona, V. O., Li, M., Ferrante, R. J., Fink, K., Zhu, S., Bian, J., Guo, L., Farrell, L. A., Hersch, S. M., et al. (2000) · Nature Medicine · doi:10.1038/77528 · Cited by 1,060
Yrjänheikki, J., Kauppinen, T. M., Keinänen, R., Goldsteins, G., Chan, P. H., & Koıstınaho, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13496 · Cited by 1,040
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
Yrjänheikki, J., Keinänen, R., Pellikka, M., Hökfelt, T., & Koistinaho, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15769 · Cited by 1,006
MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES
González-Scarano, F., & Baltuch, G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.219 · Cited by 984
Tikka, T., Fiebich, B. L., Goldsteins, G., Keinänen, R., & Koistinaho, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02580.2001 · Cited by 958
Multiple Sclerosis and Chronic Autoimmune Encephalomyelitis
Kornek, B., Storch, M. K., Weissert, R., Wallstroem, E., Stefferl, A., Olsson, T. P., Linington, C., Schmidbauer, M., & Lassmann, H. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64537-3 · Cited by 935
Self-citationGlutamate excitotoxicity in a model of multiple sclerosis
Pitt, D., Werner, P., & Raine, C. S. (2000) · Nature Medicine · doi:10.1038/71555 · Cited by 744
Matrix metalloproteinases and diseases of the CNS
Yong, V. W., Forsyth, P. A., Bell, R. B., Krekoski, C. A., & Edwards, D. R. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01169-7 · Cited by 635
Storch, M., Stefferl, A., Brehm, U., Weissert, R., Wallström, E., Kerschensteiner, M., Olsson, T., Linington, C., & Lassmann, H. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00194.x · Cited by 566
Self-citationChen, D., Endres, R. L., Erickson, C. A., Weis, K. F., McGregor, M. W., Kawaoka, Y., & Payne, L. G. (2000) · Nature Medicine · doi:10.1038/80538 · Cited by 547
Tikka, T., & Koıstınaho, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7527 · Cited by 539
Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis
Benveniste, E. N. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050101 · Cited by 532
Autoimmune encephalomyelitis ameliorated by AMPA antagonists
Smith, T., Groom, A., Zhu, B., & Turski, L. (2000) · Nature Medicine · doi:10.1038/71548 · Cited by 467
Interleukin‐10 prevents experimental allergic encephalomyelitis in rats
Rott, O., Fleischer, B., & Cash, E. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240629 · Cited by 367
The link between excitotoxic oligodendroglial death and demyelinating diseases
Matute, C., Alberdi, E. M., Domercq, M., Pérez‐Cerdá, F., Pérez‐Samartín, A., & Sánchez‐Gómez, M. V. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01746-x · Cited by 346
Piddlesden, S. J. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)90424-6 · Cited by 288
Progress in determining the causes and treatment of multiple sclerosis
Noseworthy, J. H. (1999) · Nature · doi:10.1038/399a040 · Cited by 275
Safety of long-term high-dose minocycline in the treatment of acne
Goulden, V., GLASS, D., & Cunliffe, W. J. (1996) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1996.tb06972.x · Cited by 218
Peroxisomal Disorders: Genotype, Phenotype, Major Neuropathologic Lesions, and Pathogenesis
Powers, J. M., & Moser, H. W. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00139.x · Cited by 208
Matrix metalloproteinases in inflammatory demyelination
Kieseier, B. C., Seifert‐Held, T., Giovannoni, G., & Hartung, H. (1999) · Neurology · doi:10.1212/wnl.53.1.20 · Cited by 167
Greenwald, R. A., Moak, S. A., Ramamurthy, N. S., & Golub, L. M. (1992) · PubMed · Cited by 164
Interleukin‐12 induces interferon‐γ‐dependent switching of IgG alloantibody subclass
Gracie, J. A., & Bradley, J. A. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260605 · Cited by 156
Indictment of the microglia as the villain in multiple sclerosis
Sriram, S., & Rodriguez, M. (1997) · Neurology · doi:10.1212/wnl.48.2.464 · Cited by 148
Stefferl, A., Brehm, U., Storch, M. K., Lambracht‐Washington, D., Bourquin, C., Wonigeit, K., Lassmann, H., & Linington, C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.1.40 · Cited by 143
Self-citationPiddlesden, S. J., Lassmann, H., Zimprich, F., Morgan, B. P., & Linington, C. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)91046-f · Cited by 137
Self-citationEffective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors
Liedtke, W., Cannella, B., Mazzaccaro, R. J., Clements, J. M., Miller, K., Wucherpfenning, K. W., Gearing, A. J. H., & Raine, C. S. (1998) · Annals of Neurology · doi:10.1002/ana.410440110 · Cited by 128
Khoruts, A., Miller, S. D., & Jenkins, M. K. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.10.5011 · Cited by 126
Graesser, D., Mahooti, S., & Madri, J. A. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00275-7 · Cited by 88
Macrophage responses in inflammatory demyelinating neuropathies
Griffin, J. W., Stoll, G., Li, C. Y., Tyor, W. R., & Cornblath, D. R. (1990) · Annals of Neurology · doi:10.1002/ana.410270717 · Cited by 81
Schlapbach, R., Spanaus, K., Malipiero, U., Lens, S. M. A., Tasinato, A., Tschopp, J., & Fontana, A. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(200012)30:12 · Cited by 74
Self-citationTreatment of Destructive Arthritic Disorders with MMP Inhibitors
Greenwald, R. A. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb24734.x · Cited by 72
Kardong, K. V., & Berkhoudt, H. (1998) · Brain Behavior and Evolution · doi:10.1159/000006579 · Cited by 65
MINOCYCLINE FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
Alarcón, G. S. (1998) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70022-3 · Cited by 17
Interleukin‐10 is an Unequivocal Th2 Parameter in the Rat, whereas Interleukin‐4 is Not *
Vandebriel, R. J., Meredith, C., Scott, M. P., van Dijk, M., & Loveren, H. V. (2000) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2000.00804.x · Cited by 16
Sperfeld (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199911)46:5 · Cited by 2
The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2
Eugster (1998) · Pure Amsterdam UMC · doi:10.1002/(sici)1521-4141(199807)28:07 · Cited by 2
Self-citationParchi, P., Giese, A., Capellari, S., Brown, P., Schulz-Schaeffer, W., Windl, O., Zerr, I., Budka, H., Kopp, N., Piccardo, P., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199908)46:2
Cited by
Sorted by citations
Minocycline: Far beyond an Antibiotic
Garrido‐Mesa, N., Zarzuelo, A., & Gálvez, J. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12139 · Cited by 935
The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821
Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases
Hu, J., den Steen, P. E. V., Sang, Q. A., & Opdenakker, G. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2308 · Cited by 806
Pathophysiology and pharmacologic treatment of acute spinal cord injury*1
Kwon, B. K. (2004) · The Spine Journal · doi:10.1016/j.spinee.2003.07.007 · Cited by 705
Ledeboer, A., Sloane, E. M., Milligan, E. D., Frank, M. G., Mahony, J. H., Maier, S. F., & Watkins, L. R. (2005) · Pain · doi:10.1016/j.pain.2005.02.009 · Cited by 677
Metadata
- Authors
- Popovic, N., Schubart, A., Goetz, B. D., Zhang, S., Linington, C., & Duncan, I. D.
- Affiliations
- Max Planck Society (DE)
- University of Wisconsin–Madison (US)
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2001-12-21
- Volume
- 51
- Issue
- 2
- Pages
- 215-223
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2085429548
- Cited by
- 295
- References
- 39
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 8 · 2017: 14 · 2016: 14 · 2015: 7 · 2014: 7 · 2013: 11 · 2012: 9
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- minocycline, tetracycline, experimental autoimmune encephalomyelitis, multiple sclerosis, relapsing-remitting multiple sclerosis, anti-inflammatory therapy, microglial activation, MMP-2, demyelination, neuroprotection, immune deviation
- MeSH terms
- Animals, Anti-Bacterial Agents, Brain, Chronic Disease, Encephalomyelitis, Autoimmune, Experimental, Female, Immunization, Minocycline, Myelin Proteins, Recurrence, Th1 Cells, Th2 Cells, Myelin-Associated Glycoprotein, Rats, Myelin-Oligodendrocyte Glycoprotein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review