Cited by 295Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration MechanismsPeripheral Neuropathies and Disorders

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Inhibition of autoimmune encephalomyelitis by a tetracycline

Popovic, Natalija, Schubart, Anna, Goetz, Brian D., Zhang, Su‐Chun, Linington, Chris, Duncan, Ian D.·2002·Annals of Neurology

DOI 10.1002/ana.10092

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Abstract

We have explored the use of minocycline, a tetracycline with antiinflammatory properties, to treat chronic relapsing-remitting experimental allergic encephalomyelitis, an animal model of multiple sclerosis. Therapeutic treatment with minocycline dramatically suppresses ongoing disease activity and limits disease progression. Disease suppression is associated with immune deviation in the periphery and with suppression of the inflammatory cascade in the central nervous system. This association is demonstrated by inhibition of microglial activation and metalloproteinase-2 expression, which results in a concomitant decrease in inflammation and demyelination. As an established antiinflammatory drug with neuroprotective properties, minocycline may provide a novel therapeutic agent for relapsing-remitting multiple sclerosis.

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Authors: Popovic, N., Schubart, A., Goetz, B. D., Zhang, S., Linington, C., & Duncan, I. D.
Affiliations: Max Planck Society (DE)
University of Wisconsin–Madison (US)
ORCID: Schubart, Anna
Goetz, Brian D.
Zhang, Su‐Chun
Duncan, Ian D.
Venue: Annals of Neurology
Publisher: Wiley
Published: 2001-12-21
Volume: 51
Issue: 2
Pages: 215-223
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.10092
OpenAlex: W2085429548
Cited by: 295
References: 39
Citations by year: 2026: 1 · 2025: 2 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 8 · 2017: 14 · 2016: 14 · 2015: 7 · 2014: 7 · 2013: 11 · 2012: 9
FWCI: 8.48
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Max Planck Digital Library (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Keywords: minocycline, tetracycline, experimental autoimmune encephalomyelitis, multiple sclerosis, relapsing-remitting multiple sclerosis, anti-inflammatory therapy, microglial activation, MMP-2, demyelination, neuroprotection, immune deviation
MeSH terms: Animals, Anti-Bacterial Agents, Brain, Chronic Disease, Encephalomyelitis, Autoimmune, Experimental, Female, Immunization, Minocycline, Myelin Proteins, Recurrence, Th1 Cells, Th2 Cells, Myelin-Associated Glycoprotein, Rats, Myelin-Oligodendrocyte Glycoprotein

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Inhibition of autoimmune encephalomyelitis by a tetracycline

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