Cited by 437Multiple Sclerosis Research StudiesPregnancy and Medication ImpactPsoriasis: Treatment and Pathogenesis

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Treatment of multiple sclerosis with the pregnancy hormone estriol

Sicotte, Nancy L., Liva, Stephanie M., Klutch, Rochelle, Pfeiffer, Paul, Bouvier, Seth, Odesa, Sylvia, Wu, T. C. Jackson, Voskuhl, Rhonda R.·2002·Annals of Neurology

DOI 10.1002/ana.10301

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Abstract

Multiple sclerosis patients who become pregnant experience a significant decrease in relapses that may be mediated by a shift in immune responses from T helper 1 to T helper 2. Animal models of multiple sclerosis have shown that the pregnancy hormone, estriol, can ameliorate disease and can cause an immune shift. We treated nonpregnant female multiple sclerosis patients with the pregnancy hormone estriol in an attempt to recapitulate the beneficial effect of pregnancy. As compared with pretreatment baseline, relapsing remitting patients treated with oral estriol (8mg/day) demonstrated significant decreases in delayed type hypersensitivity responses to tetanus, interferon‐γ levels in peripheral blood mononuclear cells, and gadolinium enhancing lesion numbers and volumes on monthly cerebral magnetic resonance images. When estriol treatment was stopped, enhancing lesions increased to pretreatment levels. When estriol treatment was reinstituted, enhancing lesions again were significantly decreased. Based on these results, a larger, placebo‐controlled trial of estriol is warranted in women with relapsing remitting multiple sclerosis. This novel treatment strategy of using pregnancy doses of estriol in multiple sclerosis has relevance to other autoimmune diseases that also improve during pregnancy.

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Emerging Oral Medications for Multiple Sclerosis
Fredrikson, S., & Hillert, J. A. (2012) · doi:10.2217/9781780840482
Sex hormones and multiple sclerosis: another informative failur e
Hooton, I. (2016)
Immunomodulatory Therapy for Multiple Sclerosis
Cortese, I. C. M., & Nath, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-44022-4_43
Sex Differences in Autoimmune Diseases
Voskuhl, R. R., & Wang, T. T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00113-9
Self-citation
The role of oral contraceptives in optic neuritis: the story behind the study, initial experiences, and lessons learned
Trufyn, J. (2013) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/28340
The Effects of Multiple Sclerosis and Disease Modifying Therapy on Pregnancy
Johal, T. K. (2017) · University of Ottawa Journal of Medicine · doi:10.18192/uojm.v7i1.1758
The initial results from a Brazilian database
Fragoso, Y. D., Finkelsztejn, A., Comini-Frota, E. R., da Gama, P. D., Grzesiuk, A. K., Mathias, J., Khouri, N., Alves‐Leon, S. V., Morales, R. R., Lana–Peixoto, M. A., et al. (2009)
Other therapeutics in the pipeline & future directions
Karmon, Y., Mehta, B. K., & Weinstock‐Guttman, B. (2011) · doi:10.2217/ebo.11.156
Estrogen Therapy in a Viral Murine Model of Multiple Sclerosis
Gomez, F. P. (2012) · OakTrust (Texas A&M University Libraries)

Authors: Sicotte, N. L., Liva, S. M., Klutch, R., Pfeiffer, P., Bouvier, S., Odesa, S., Wu, T. C. J., & Voskuhl, R. R.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Voskuhl, Rhonda R.
ORCID: Sicotte, Nancy L.
Voskuhl, Rhonda R.
Venue: Annals of Neurology
Publisher: Wiley
Published: 2002-08-19
Volume: 52
Issue: 4
Pages: 421-428
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.10301
OpenAlex: W2135551891
Cited by: 435
References: 41
Citations by year: 2026: 7 · 2025: 8 · 2024: 10 · 2023: 13 · 2022: 13 · 2021: 9 · 2020: 14 · 2019: 12 · 2018: 22 · 2017: 11 · 2016: 24 · 2015: 19 · 2014: 30 · 2013: 25 · 2012: 30
FWCI: 12.95
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: multiple sclerosis, estriol, pregnancy hormones, relapsing-remitting multiple sclerosis, interferon-gamma, delayed-type hypersensitivity, gadolinium-enhancing lesions, disease-modifying therapy
MeSH terms: Adolescent, Adult, Estriol, Female, Humans, Hypersensitivity, Delayed, Magnetic Resonance Imaging, Middle Aged, Multiple Sclerosis, Pregnancy, Recurrence, Biomarkers, Th1 Cells, Cross-Over Studies

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Treatment of multiple sclerosis with the pregnancy hormone estriol

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