The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Maternal neuronal antibodies associated with autism and a language disorder
Open accessAbstract
Neurodevelopmental disorders could be caused by maternal antibodies or other serum factors. We detected serum antibodies binding to rodent Purkinje cells and other neurons in a mother of three children: the first normal, the second with autism, and the third with a severe specific language disorder. We injected the serum (0.5–1.0ml/day) into pregnant mice during gestation and found altered exploration and motor coordination and changes in cerebellar magnetic resonance spectroscopy in the mouse offspring, comparing with offspring of mice injected with sera from mothers of healthy children. This evidence supports a role for maternal antibodies in some forms of neurodevelopmental disorder. Ann Neurol 2003;53:533–537
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“animal models have yielded many intriguing insights into the effects and mechanisms of inflammation and immune activation, as well as the role of toxic agents, in inducing autism-like behaviors in rodent and other species [103, 104, 112–115, 207].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [112]
In the citing paper
“investigators injected maternal serum containing anti-brain antibodies into pregnant mice daily between E10 and E17, and observed reduced exploration and motor control in their offspring as compared with the offspring of untreated dams”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Dalton et al, 2003
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(2000) · Cited by 919
Frahm, J., Bruhn, H., Gyngell, M. L., Merboldt, K. D., Hänicke, W., & Sauter, R. (1989) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910090110 · Cited by 711
Lord, C., Cook, E. H., Leventhal, B. L., & Amaral, D. G. (2000) · Neuron · doi:10.1016/s0896-6273(00)00115-x · Cited by 555
Rapin, I., & Katzman, R. (1998) · Annals of Neurology · doi:10.1002/ana.410430106 · Cited by 288
Synphilin-1 is present in Lewy bodies in Parkinson's disease
Wakabayashi, K., Engelender, S., Yoshimoto, M., Tsuji, S., Ross, C. A., & Takahashi, H. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200004)47:4 · Cited by 269
Self-citationEffects of cytotoxic hippocampal lesions in mice on a cognitive test battery
Deacon, R. M. J., Bannerman, D. M., Kirby, B. P., Croucher, A. P., & Rawlins, J. N. P. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00451-x · Cited by 189
Self-citationAutism: recent molecular genetic advances
Lamb, J. A. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.6.861 · Cited by 164
Arthrogryposis multiplex congenita with maternal autoantibodies specific for a fetal antigen
Vincent, A. C., Newland, C., Beeson, D., Riemersma, S. A., Newsom–Davis, J., Brueton, L., & Huson, S. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92652-6 · Cited by 157
Self-citationEarly behavioural changes in scrapie‐affected mice and the influence of dapsone
Guenther, K. M., Deacon, R. M. J., Perry, V. H., & Rawlins, J. N. P. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01645.x · Cited by 150
Self-citationLougee, L., Perlmutter, S., Nicolson, R., Garvey, M. A., & Swedo, S. E. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200009000-00011 · Cited by 140
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Findings in magnetic resonance spectroscopy in patients with Autism spectrum disorder
Tenorio, I. A., Brandão, L. A., Filho, A. S., Sabrá, S., Bandeira, T. L., Bandeira, I. M., dos Santos, A. M. E. D., Manuel, N. A. M., Mitre, P. P. S., Rebello, C. M., et al. (2023) · GSC Advanced Research and Reviews · doi:10.30574/gscarr.2023.17.3.0453
O uso de ácido valproico para a indução de modelos animais de autismo: uma revisão
Ferreira, A. L. D. A. S., Doreto, A. C. F., Porfírio, A. R., Canêdo, J. A., & Barreto, S. P. S. (2024) · Journal Archives of Health · doi:10.46919/archv5n3espec-495
Metadata
- Authors
- Dalton, P., Deacon, R., Blamire, A., Pike, M., McKinlay, I., Stein, J., Styles, P., & Vincent, A.
- Affiliations
- University of Oxford (GB)
- John Radcliffe Hospital (GB)
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2003-03-24
- Volume
- 53
- Issue
- 4
- Pages
- 533-537
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2105371617
- Cited by
- 204
- References
- 20
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 9 · 2022: 5 · 2021: 9 · 2020: 10 · 2019: 12 · 2018: 9 · 2017: 9 · 2016: 10 · 2015: 15 · 2014: 10 · 2013: 14 · 2012: 11
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- maternal antibodies, autism spectrum disorder, specific language impairment, Purkinje cells, cerebellum, neurodevelopmental disorders, mouse offspring, motor coordination, maternal-fetal immune transfer
- MeSH terms
- Adult, Animals, Autistic Disorder, Child, Dyslexia, Postural Balance, Female, Humans, Immunoglobulin G, Immunoglobulin M, Immunity, Maternally-Acquired, Magnetic Resonance Imaging, Male, Motor Activity, Magnetic Resonance Spectroscopy, Pregnancy, Purkinje Cells, Mice
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