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Maternal neuronal antibodies associated with autism and a language disorder
Open accessAbstract
Neurodevelopmental disorders could be caused by maternal antibodies or other serum factors. We detected serum antibodies binding to rodent Purkinje cells and other neurons in a mother of three children: the first normal, the second with autism, and the third with a severe specific language disorder. We injected the serum (0.5–1.0ml/day) into pregnant mice during gestation and found altered exploration and motor coordination and changes in cerebellar magnetic resonance spectroscopy in the mouse offspring, comparing with offspring of mice injected with sera from mothers of healthy children. This evidence supports a role for maternal antibodies in some forms of neurodevelopmental disorder. Ann Neurol 2003;53:533–537
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“animal models have yielded many intriguing insights into the effects and mechanisms of inflammation and immune activation, as well as the role of toxic agents, in inducing autism-like behaviors in rodent and other species [103, 104, 112–115, 207].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [112]
In the citing paper
“investigators injected maternal serum containing anti-brain antibodies into pregnant mice daily between E10 and E17, and observed reduced exploration and motor control in their offspring as compared with the offspring of untreated dams”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Dalton et al, 2003
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Self-citationEffects of cytotoxic hippocampal lesions in mice on a cognitive test battery
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Self-citationEarly behavioural changes in scrapie‐affected mice and the influence of dapsone
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Detection of Maternal Antibodies in Infantile Autism
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Self-citationNilsson, M., Waters, N., Waters, N., Carlsson, A., & Carlsson, M. L. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170008 · Cited by 59
Pathogenic autoantibodies to neuronal proteins in neurological disorders
Vincent, A. C., Lily, O., & Palace, J. A. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00210-6 · Cited by 45
Self-citationJames, W. H. (2000) · Teratology · doi:10.1002/1096-9926(200011)62:5 · Cited by 40
Vincent, A. C., Deacon, R. M. J., Dalton, P., Salmond, C. H., Blamire, A. M., Pendlebury, S. T., Johansen‐Berg, H., Rajogopalan, B., Styles, P., & Stein, J. F. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00226-6 · Cited by 32
Self-citationRestricted IgG1 subclass of anti-Yo antibodies in paraneoplastic cerebellar degeneration
Amyes, E., Curnow, J., Stark, Z., Corlett, L., Sutton, I., & Vincent, A. C. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00445-8 · Cited by 27
Self-citation(2008) · The MIT Press eBooks · doi:10.7551/mitpress/7649.003.0010 · Cited by 4
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Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149
“The potential role for maternal antibodies as a pathogenic factor also has been proposed.(19) Cerebrospinal fluid (CSF) studies demonstrated no evidence of inflammation by standard cell counts, protein electrophoresis, or measurements of quinolinic acid and neopterin.”
BackgroundMaternal Immune Activation Alters Fetal Brain Development through Interleukin-6
Smith, S. E. P., Li, J., Garbett, K., Mirnics, K., & Patterson, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2178-07.2007 · Cited by 1,605
“…gene expression change compared with the overall average intensity (green, decreased; red, increased; black, unchanged). react with the fetal brain, as has been proposed to occur in autism (Warren et al., 1990; Dalton et al., 2003; Vincent et al., 2003; Singer et al., 2006; Zimmerman et al., 2007).”
BackgroundMuhle, R., Trentacoste, S. V., & Rapin, I. (2004) · Pediatrics · doi:10.1542/peds.113.5.e472 · Cited by 1,207
Maternal immune activation and abnormal brain development across CNS disorders
Knuesel, I., Chicha, L., Britschgi, M., Schobel, S. A., Bodmer, M., Hellings, J. A., Toovey, S., & Prinssen, E. P. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.187 · Cited by 880
Modabbernia, A., Velthorst, E., & Reichenberg, A. (2017) · Molecular Autism · doi:10.1186/s13229-017-0121-4 · Cited by 809
“It is possible that the association of maternal autoimmune disease with risk of ASD is partly mediated through the effect of maternal inflammatory mediators and autoantibodies on fetal neurodevelopment [72, 73].”
Background
Metadata
- Authors
- Dalton, P., Deacon, R., Blamire, A., Pike, M., McKinlay, I., Stein, J., Styles, P., & Vincent, A.
- Affiliations
- University of Oxford (GB)
- John Radcliffe Hospital (GB)
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2003-03-24
- Volume
- 53
- Issue
- 4
- Pages
- 533-537
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2105371617
- Cited by
- 204
- References
- 20
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 9 · 2022: 5 · 2021: 9 · 2020: 10 · 2019: 12 · 2018: 9 · 2017: 9 · 2016: 10 · 2015: 15 · 2014: 10 · 2013: 14 · 2012: 11
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- maternal antibodies, autism spectrum disorder, specific language impairment, Purkinje cells, cerebellum, neurodevelopmental disorders, mouse offspring, motor coordination, maternal-fetal immune transfer
- MeSH terms
- Adult, Animals, Autistic Disorder, Child, Dyslexia, Postural Balance, Female, Humans, Immunoglobulin G, Immunoglobulin M, Immunity, Maternally-Acquired, Magnetic Resonance Imaging, Male, Motor Activity, Magnetic Resonance Spectroscopy, Pregnancy, Purkinje Cells, Mice
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