Detection of Maternal Antibodies in Infantile Autism
Open accessAbstract
Maternal antibodies reactive with antigenic proteins expressed on the cell surface of paternal lymphocytes can be detected in couples with histories of more than one miscarriage or stillbirth. It is possible, but not proven, that these antibodies also react with tissues of the fetus and result in fetal death. Since many mothers of autistic children have a history of pregnancy disorder, antibodies were studied in 11 mothers of autistic children who were 6 years of age or younger. Six of the mothers had antibodies that reacted with lymphocytes of the autistic child. Five of these six mothers had a history of pregnancy disorder. Since antigens expressed on lymphocytes are found on cells of the central nervous system and, perhaps, other tissues of the developing embryo, it is suggested that aberrant maternal immunity may be associated with the development of some cases of infantile autism.
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Warren et al. found that six of 11 mothers of young children had circulating antibodies targeting lymphocyte antigens of their children.
“a study that examined serum from 11 mothers of young children and found six with circulating antibodies that targeted lymphocyte antigens of the children”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Warren et al, 1990
Maternal autoantibodies to fetal brain proteins have been found in mothers of autistic children.
“The notion that maternal autoantibodies to elements in the fetal compartment could elicit changes in neurodevelopment began over 25 years ago”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Warren et al, 1990
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- Authors
- WARREN, R. P., COLE, P., ODELL, J. D., PINGREE, C. B., WARREN, W. L., WHITE, E., YONK, J., & SINGH, V. K.
- Affiliations
- Utah State University (US)
- ORCID
- SINGH, VIJENDRA K.
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 1990-11
- Volume
- 29
- Issue
- 6
- Pages
- 873-877
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W1993823030
- Cited by
- 82
- References
- 14
- Citations by year
- 2024: 3 · 2023: 3 · 2021: 1 · 2020: 3 · 2019: 6 · 2018: 3 · 2016: 6 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 7
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH42119)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Keywords
- infantile autism, maternal antibodies, pregnancy disorders, miscarriage, stillbirth, cell surface antigens, fetal death, maternal-fetal immune interaction
- MeSH terms
- Adolescent, Autistic Disorder, Child, Child, Preschool, Female, Humans, Isoantibodies, Isoantigens, Lymphocytes, Male, Maternal-Fetal Exchange, Pregnancy
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