The DOI matches its Crossref record.
Treatment of acute Nipah encephalitis with ribavirin
Abstract
Nipah virus, a newly identified paramyxovirus caused a severe outbreak of encephalitis in Malaysia with high fatalities. We report an open-label trial of ribavirin in 140 patients, with 54 patients who were managed prior to the availability of ribavirin or refused treatment as control. There were 45 deaths (32%) in the ribavirin arm; 29 deaths (54%) occurred in the control arm. This represents a 36% reduction in mortality (p = 0.011). There was no associated serious side effect. This study suggests that ribavirin is able to reduce the mortality of acute Nipah encephalitis.
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Cited by
Tunkel, A. R., Glaser, C. A., Bloch, K. C., Sejvar, J. J., Marra, C. M., Roos, K. L., Hartman, B. J., Kaplan, S. L., Scheld, W. M., & Whitley, R. J. (2008) · Clinical Infectious Diseases · doi:10.1086/589747 · Cited by 1,193
Nipah virus: Impact, origins, and causes of emergence
Epstein, J. H., Field, H. E., Luby, S., Pulliam, J. R. C., & Daszak, P. (2006) · Current Infectious Disease Reports · doi:10.1007/s11908-006-0036-2 · Cited by 272
Nipah Virus: Past Outbreaks and Future Containment
Soman Pillai, V., Krishna, G., & Valiya Veettil, M. (2020) · Viruses · doi:10.3390/v12040465 · Cited by 194
Griffin, B. D., Leung, A., Chan, M., Warner, B. M., Ranadheera, C., Tierney, K., Audet, J., Frost, K. L., Safronetz, D., Embury-Hyatt, C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-47549-y · Cited by 26
Metadata
- Authors
- Chong, H.-T., Kamarulzaman, A., Tan, C.-T., Goh, K.-J., Thayaparan, T., Kunjapan, S. R., Chew, N.-K., Chua, K.-B., & Lam, S.-K.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2001
- Volume
- 49
- Issue
- 6
- Pages
- 810-813
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2106093126
- Cited by
- 292
- References
- 0
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Treatment of acute Nipah encephalitis with ribavirin. https://app.cochat.ai/papers/10.1002/ana.1062
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- Chong, H.-T., Kamarulzaman, A., Tan, C.-T., Goh, K.-J., Thayaparan, T., Kunjapan, S. R., Chew, N.-K., Chua, K.-B., & Lam, S.-K. (2001). Treatment of acute Nipah encephalitis with ribavirin. Annals of Neurology. https://doi.org/10.1002/ana.1062
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
