The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
In vivo detection of microglial activation in frontotemporal dementia
Open accessAbstract
Using positron emission tomography and [(11)C](R)-PK11195, a marker of "peripheral benzodiazepine sites" that is upregulated on activated microglia during progressive tissue pathology, we show increased binding of [(11)C](R)-PK11195 in frontotemporal lobar degeneration in the typically affected frontotemporal brain regions. This implies the presence of an active glial response reflecting progressive neuronal degeneration. It also suggests that increased [(11)C](R)-PK11195 binding, previously demonstrated for Alzheimer's disease, may occur independently from increased amyloid plaque formation, given that it is not a characteristic feature of frontotemporal lobar degeneration.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In vivo PET studies320,321 and immunohistochemistry studies322–324 have found increased microglial activation in the frontal and temporal cortices of patients with FTD.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [320]
Citations
Cites
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047
In-vivo measurement of activated microglia in dementia
Cagnin, A., Brooks, D. J., Kennedy, A. M., Gunn, R. N., Myers, R., Turkheimer, F. E., Jones, T., & Banati, R. B. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05625-2 · Cited by 1,054
Self-citationThe peripheral benzodiazepine binding site in the brain in multiple sclerosis
Banati, R. B., Newcombe, J., Gunn, R. N., Cagnin, A., Turkheimer, F., Heppner, F., Price, G., Wegner, F., Giovannoni, G., Miller, D. H., et al. (2000) · Brain · doi:10.1093/brain/123.11.2321 · Cited by 661
Self-citationBruyn, R. P. M. (2003) · Clinical Neurology and Neurosurgery · doi:10.1016/s0303-8467(02)00110-5 · Cited by 510
Thalamic microglial activation in ischemic stroke detected in vivo by PET and [ 11 C]PK11195
Pappatà, S., Levasseur, M., Gunn, R. N., Myers, R., Crouzel, C., Syrota, A., Jones, T., Kreutzberg, G. W., & Banati, R. B. (2000) · Neurology · doi:10.1212/wnl.55.7.1052 · Cited by 252
Self-citationMyers, R., Manjil, L. G., Cullen, B. M., Price, G. W., Frackowiak, R. S. J., & Cremer, J. E. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.64 · Cited by 182
Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD
Rosen, H., Hartikainen, K. M., Jagust, W., Kramer, J. H., Reed, B., Cummings, J. L., Boone, K., Ellis, W. G., Miller, C. A., & Miller, B. L. (2002) · Neurology · doi:10.1212/wnl.58.11.1608 · Cited by 175
The neuropathology and biochemistry of frontotemporal dementia
Muñoz, D. G., Dickson, D. W., Bergeron, C., Mackenzie, I. R., Delacourte, A., & Zhukareva, V. A. (2003) · Annals of Neurology · doi:10.1002/ana.10571 · Cited by 83
Microglial reaction in Pick's disease
Paulus, W., Bancher, C., & Jellinger, K. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90147-d · Cited by 42
Pick body disease and Pick syndrome*
Uchihara, T., Ikeda, K., & Tsuchiya, K. (2003) · Neuropathology · doi:10.1046/j.1440-1789.2003.00523.x · Cited by 33
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–188 of 188
In vivo evidence for pre‐symptomatic neuroinflammation in a MAPT mutation carrier
Bevan‐Jones, W. R., Cope, T. E., Jones, P. S., Passamonti, L., Hong, Y. T., Fryer, T., Arnold, R., Coles, J. P., Aigbirhio, F. I., O'Brien, J. T., et al. (2019) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.683 · Cited by 36
“Neuroinflammation has been implicated in FTD by cerebrospinal fluid,(6) genetic, and PET studies.(10) Microglial activation may alter brain homeostasis in protective or deleterious manners through inflammatory pathways, cytotoxicity, and changes in neuronal plasticity.”
BackgroundEvaluation of Methods for Generating Parametric ( R )-[ 11 C]PK11195 Binding Images
Schuitemaker, A., van Berckel, B. N. M., Kropholler, M. A., Kloet, R. W., Jonker, C., Scheltens, P., Lammertsma, A. A., & Boellaard, R. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600459 · Cited by 36
Intrinsic timescales and predictive allostatic interoception in brain health and disease
Ibanez, A., & Northoff, G. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105510 · Cited by 36
“Soysal et al., 2020), inflammatory (Cagnin et al., 2004; Sj ¨ ogren et al., 2004; Yaffe et al., 2004; Rentzos et al., 2006; Dik et al., 2007; Seeman et al., 2008; Zhang, 2015; Bright et al., 2019; Duran-Aniotz et al., 2021), stress hormone (Woolley et al., 2014), and neurodegenerative factors…”
Nanomedicine in cerebral palsy
Kannan, S., Balakrishnan, B., Nance, E., Johnston, M., & Rangaramanujam, K. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s35979 · Cited by 33
Novel PET Biomarkers to Disentangle Molecular Pathways across Age-Related Neurodegenerative Diseases
Wilson, H., Politis, M., Rabiner, E. A., & Middleton, L. T. (2020) · Cells · doi:10.3390/cells9122581 · Cited by 34
“Increased binding of TSPO PET radioligands, interpreted as microglia activation, has been reported in PD [85–88], PDD [89], MSA [90], PSP [91], CBS [92], HD [93], AD [94,95], FTD [96,97] and ALS [98,99].”
BackgroundLiu, E., Karpf, L., & Bohl, D. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.767041 · Cited by 32
“− PET scanning: TSPO binding in cortical frontal, mesial temporal, subcortical regions, prefrontal cortex, hippocampal, and parahippocampal regions (Cagnin et al., 2004; Turner et al., 2004; Miyoshi et al., 2010; Chew and Atassi, 2019).”
BackgroundCannabidiol (CBD) treatment improves spatial memory in 14-month-old female TAU58/2 transgenic mice
Kreilaus, F., Przybyla, M., Ittner, L. M., & Karl, T. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113812 · Cited by 33
Fujinaga, M., Luo, R., Kumata, K., Zhang, Y., Hatori, A., Yamasaki, T., Xie, L., Mori, W., Kurihara, Y., Ogawa, M., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00374 · Cited by 30
The translocator protein (18 kDa) and its role in neuropsychiatric disorders
Barichello, T., Simões, L. R., Collodel, A., Giridharan, V. V., Dal‐Pizzol, F., Macêdo, D. S., & Quevedo, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.010 · Cited by 30
“…(MS) (Janssen et al., 2016), traumatic brain injury (Papadopoulos and Lecanu, 2009), ischaemic stroke (Gerhard et al., 2005), frontotemporal dementia (Cagnin et al., 2004), human immunodeficiency virus (HIV) (Zhou et al., 2014), and paediatric autoimmune neuropsychiatric disorders associated with…”
Inflammatory and Pro-resolving Mediators in Frontotemporal Dementia and Alzheimer’s Disease
Fraga, V. G., Magalhaes, C. A., Loures, C. D. M. G., de Souza, L. C., Guimarães, H. C., Zauli, D. A. G., Ferriani, M. D. G. C., Ferreira, C. N., Caramelli, P., Sousa, L. P., et al. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.008 · Cited by 28
Neuroinflammatory Pathways in the ALS-FTD Continuum: A Focus on Genetic Variants
Marchi, F. D., Tondo, G., Corrado, L., Menegon, F., Aprile, D., Anselmi, M., D’Alfonso, S., Comi, C., & Mazzini, L. (2023) · Genes · doi:10.3390/genes14081658 · Cited by 31
“Since the early studies in FTD, the topographical distribution of microglia activation visualized using [11C]PK11195, the first and most widely used TSPO-PET tracer, colocalize with the distribution of neuronal damage and pathology, thus including frontal, prefrontal, and temporal cortices [148,149].”
BackgroundSchuitemaker, A., van Berckel, B. N. M., Kropholler, M. A., Veltman, D. J., Scheltens, P., Jonker, C., Lammertsma, A. A., & Boellaard, R. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.02.013 · Cited by 28
Neuroinflammation in frontotemporal lobar degeneration revealed by 11 C‐PBR28 PET
Kim, M.-J., McGwier, M., Jenko, K. J., Snow, J., Morse, C. L., Zoghbi, S. S., Pike, V. W., Innis, R. B., & Kreisl, W. C. (2019) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.50802 · Cited by 29
“In contrast to a previous study using (11)C-(R)-PK11195 that found increased TSPO binding mainly in medial temporal, subcortical, and some frontal cortical regions,(5) the present (11)C-PBR28 study found that the highest increases in binding were observed in neocortical regions – including frontal, lateral temporal, p…”
ResultNew Molecular Targets for PET and SPECT Imaging in Neurodegenerative Diseases
Benadiba, M., Luurtsema, G., Wichert‐Ana, L., Buchpiguel, C. A., & Busatto, G. F. (2012) · Brazilian Journal of Psychiatry · doi:10.1016/j.rbp.2012.07.002 · Cited by 29
Ridolfi, E., Barone, C., Scarpini, E. A., & Galimberti, D. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/939786 · Cited by 28
“of [(11)C] (R)-PK11195 in the typically affected frontotemporal brain regions, which implied the presence of activated microglia response reflecting progressive neuronal degeneration [118].”
BackgroundDuran-Aniotz, C. A., Orellana, P., Rodríguez, T. L., Henríquez, F., Cabello, V., Aguirre-Pinto, M. F., Escobedo, T., Takada, L. T., Piña‐Escudero, S. D., López, O. L., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.663407 · Cited by 27
“Patients with FTD show overexpression of tumor necrosis factor (TNF) and transforming growth factor (TGF-b1) in CSF, as well as microglia activation in atrophic areas of the brain (190, 191).”
BackgroundPerani, D., Iaccarino, L., Lammertsma, A. A., Windhorst, A. D., Edison, P., Boellaard, R., Hansson, O., Nordberg, A. K., Jacobs, A. H., & IMBI Project (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.02.004 · Cited by 25
“A PET study in FTD using (R)-[(11)C]PK11195 has shown increased uptake in frontotemporal regions and basal ganglia [51], in keeping with neuropathological findings [204].”
BackgroundHedde, J. R., Hanks, A. N., Schmidt, C. J., & Hughes, Z. A. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.04.015 · Cited by 24
Cranston, A., Wysocka, A., Steczkowska, M., Zadrożny, M., Pałasz, E., Harrington, C. R., Theuring, F., Wischik, C. M., Riedel, G., & Niewiadomska, G. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa033 · Cited by 22
“, 2014), and in dorsolateral prefrontal cortex and hippocampus (Cagnin et al., 2004).”
BackgroundPET Neuroimaging in Dementia Conditions
Perani, D., Caminiti, S. P., Carli, G., & Tondo, G. (2020) · Springer eBooks · doi:10.1007/978-3-030-53168-3_9 · Cited by 20
Brainstem glucose hypermetabolism in ALS/FTD and shorten survival: a 18 F-FDG PET/MR study
Zanovello, M., Sorarú, G., Campi, C., Anglani, M., Spimpolo, A., Berti, S., Bussè, C., Mozzetta, S., Cagnin, A., & Cecchin, D. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.262232 · Cited by 28
“As predicted, both activated microglia and astrocyte markers have been observed in imaging studies of ALS (4,5) and FTD patients (6,7).”
BackgroundSelf-citationGalectin‐3 is upregulated in frontotemporal dementia patients with subtype specificity
Borrego‐Écija, S., Pérez‐Millan, A., Antonell, A., Fort‐Aznar, L., Tilki, E. K., León‐Halcón, A., Lladó, A., Molina‐Porcel, L., Balasa, M., Juncà‐Parella, J., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13536 · Cited by 22
Neurological update: neuroimaging in dementia
Rittman, T. (2020) · Journal of Neurology · doi:10.1007/s00415-020-10040-0 · Cited by 23
Zhang, H., Ma, L., Yin, Y., Dong, L.-Q., Cheng, G., Ma, Y., Li, Y., & Xu, B. (2016) · Brain Research · doi:10.1016/j.brainres.2016.06.001 · Cited by 19
Nuclear Imaging of Inflammation in Neurologic and Psychiatric Disorders
de Vries, E. F. J., Dierckx, R., & Klein, H. C. (2006) · Current Clinical Pharmacology · doi:10.2174/157488406778249334 · Cited by 20
“dementia, like frontotemporal dementia [50].”
Phenomic Microglia Diversity as a Druggable Target in the Hippocampus in Neurodegenerative Diseases
Lana, D., Magni, G., Landucci, E., Wenk, G. L., Pellegrini-Giampietro, D. E., & Giovannini, M. G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813668 · Cited by 20
Targeting Progranulin as an Immuno-Neurology Therapeutic Approach
Boylan, M. A., Pincetic, A., Romano, G. J., Tatton, N. A., Kenkare-Mitra, S., & Rosenthal, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115946 · Cited by 19
“In FTD patients, microglial activation can be assessed with imaging biomarkers utilizing the 11 C-PK11195 positron emission tomography (PET) ligand [73], where increased frontotemporal microglial activation has been described in sporadic and genetic forms of FTD [74–76].”
MethodJorge, L., Martins, R., Canário, N., Xavier, A. C., Abrunhosa, A., Santana, I. J., & Castelo-Branco, M. S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-200840 · Cited by 19
“Moreover, this pathologic event is also present in other neurodegenerative diseases [112, 113], which are not characterized by brain amyloidosis.”
BackgroundImaging neuroinflammation in Alzheimer’s and other dementias: recent advances and future directions
Brooks, D. J. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.01.049 · Cited by 17
Multimodality Imaging in Primary Progressive Aphasia
Roytman, M., Chiang, G. C.-Y., Gordon, M. L., & Franceschi, A. M. (2022) · American Journal of Neuroradiology · doi:10.3174/ajnr.a7613 · Cited by 17
“with behavioral-variant frontotemporal dementia) in regions such as the left dorsolateral prefrontal cortex, right hippocampus, and parahippocampus.(83)”
BackgroundReyes‐Leiva, D., Dols‐Icardo, O., Sirisi, S., Cortés‐Vicente, E., Turón‐Sans, J., de Luna, N., Blesa, R., Belbin, O., Montal, V., Alcolea, D. A., et al. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.750543 · Cited by 18
Downer, O. M., Marcus, R. E. G., Zürcher, N. R., & Hooker, J. M. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00362 · Cited by 15
Pro-Inflammatory Cytokine Genes Influence the Clinical Features of Frontotemporal Lobar Degeneration
Rainero, I., Rubino, E., Cappa, G., Rota, E., Valfrè, W., Ferrero, P., Fenoglio, P., Baci, D., D’Amico, G., Vaula, G., et al. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000225962 · Cited by 15
“Using PET, significant microglia activation was shown in FTLD patients and the pattern of glial activation strictly reflected selective neuronal degeneration [”
BackgroundNew PET markers for the diagnosis of dementia
Payoux, P., & Salabert, A. (2017) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000489 · Cited by 14
Emerging Theories of Allostatic-Interoceptive Overload in Neurodegeneration
Franco-O’Byrne, D., Santamaría‐García, H. A., Migeot, J., & Ibáñez, A. M. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_471 · Cited by 13
Plasma Translocator Protein Levels and Outcomes of Acute Ischemic Stroke: A Pilot Study
Chen, W.-H., Yeh, H., Tsao, C.-W., Lien, L.-M., Chiwaya, A., Alizargar, J., & Bai, C. (2018) · Disease Markers · doi:10.1155/2018/9831079 · Cited by 14
Lok, H. C., Katzeff, J. S., Hodges, J. R., Piguet, O., Fu, Y., Halliday, G. M., & Kim, W. S. (2023) · Scientific Reports · doi:10.1038/s41598-023-35945-4 · Cited by 12
C9orf72 dipeptides activate the NLRP3 inflammasome
Rivers‐Auty, J., Hoyle, C., Pointer, A., Lawrence, C. B., Pickering-Brown, S. M., Brough, D., & Ryan, S. (2024) · Brain Communications · doi:10.1093/braincomms/fcae282 · Cited by 11
“11,12 13-16 Emerging evidence from study of other neurodegenerative diseases suggests that inflammation is not simply a passive response to neuronal death, but that it directly contributes to disease pathogenesis.”
BackgroundFluid Biomarkers of Frontotemporal Lobar Degeneration
van der Ende, E. L., & Swieten, J. C. V. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-51140-1_9 · Cited by 11
Allostatic interoception and brain health: From neurodegeneration to social adversities
Migeot, J., & Ibáñez, A. (2025) · Encyclopedia of the Human Brain · doi:10.1016/b978-0-12-820480-1.00025-5 · Cited by 10
Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau
Iyer, A. K., Vermunt, L., Mirfakhar, F. S., Minaya, M., Acquarone, M., Koppisetti, R. K., Renganathan, A., You, S., Danhash, E., Schache, K. J., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03073-2 · Cited by 14
Ciarmiello, A. (2011) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-011-1959-x · Cited by 10
“Increased uptake of CPK11195 was also reported in frontotemporal lobar degeneration [14] and HD [15].”
BackgroundRelevance of raised cerebrospinal fluid monocyte levels in patients with frontotemporal dementia
Pawlowski, M., Lueg, G., Groß, C. C., Johnen, A., Krämer, J., Weckesser, M., Wiendl, H., Meuth, S. G., & Duning, T. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.032 · Cited by 12
“…et al., 2014), recent FTD studies demonstrated microglial activation in the cortical and subcortical regions of the frontal and temporal lobes (Cagnin et al., 2004; Lant et al., 2014), an increased prevalence of autoimmune diseases (Miller et al., 2013; Rosso et al., 2003), and risk…”
BackgroundSexton, M., Woodruff, G., Cudaback, E., Kreitzer, F. R., Xu, C., Lin, Y. H., Möller, T., Bai, M., Manning, H. C., Bornhop, D. J., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008271 · Cited by 9
“For example, [(11)C]-PK 11195 reliably monitors increases in TSPO expression in brain tumors (including malignant astrocytomas), as well as in the activated microglia found in patients with multiple sclerosis, stroke, epilepsy, Alzheimer’s disease, Huntington’s disease and AIDS [2,3,4,5,6,7,8,9,10].”
Radiopharmaceuticals for imaging chronic lymphocytic inflammation
Malviya, G., de Vries, E. F. J., Dierckx, R., & Signore, A. (2007) · Brazilian Archives of Biology and Technology · doi:10.1590/s1516-89132007000600002 · Cited by 9
“[11C]PK11195 PET could also demonstrate microglia activation in other forms of dementia, like frontotemporal dementia (Cagnin et al., 2004).”
Song, P.-J., Barc, C., Arlicot, N., Guilloteau, D., Bernard, S., Sarradin, P., Chalon, S., Garreau, L., Kung, H. F., Lantier, F., et al. (2010) · Molecular Imaging and Biology · doi:10.1007/s11307-010-0321-1 · Cited by 11
Cognitive Impairment and Dementias.
Khosravi, M., Newberg, A., & Alavi, A. (2018) · Seminars in nuclear medicine · doi:10.1053/j.semnuclmed.2018.07.005 · Cited by 8
Genetic and degenerative disorders primarily causing dementia
Masdeu, J. C., & Pascual, B. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53485-9.00026-x · Cited by 6
“In a small pilot study (Cagnin et al., 2004), 11C-PK11195 PET showed increased binding in the typically affected frontotemporal brain regions.”
Perspectives in TSPO PET Imaging for Neurologic Diseases
Song, Y. S. (2019) · Nuclear Medicine and Molecular Imaging · doi:10.1007/s13139-019-00620-y · Cited by 6
The behavioural phenotype of 14-month-old female TAU58/2 transgenic mice
Kreilaus, F., Masanetz, R. K., Watt, G., Przybyla, M., Ittner, A., Ittner, L. M., & Karl, T. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112943 · Cited by 6
Potential Protein Blood-based Biomarkers in Different Types of Dementia: A Therapeutic Overview
Manzine, P. R., Vatanabe, I. P., Grigoli, M. M., Pedroso, R. V., Monteiro, M. P. A. O., de Oliveira, D. D. S. M. S., Nascimento, C. M. C., Peron, R., Orlandi, F. D. S., & Cominetti, M. R. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220408124809 · Cited by 4
Newberg, A. B., Coble, R., Khosravi, M., & Alavi, A. A. (2022) · PET Clinics · doi:10.1016/j.cpet.2022.03.009 · Cited by 4
PET Imaging of Translocator Protein Expression in Neurological Disorders
Brooks, D. J. (2020) · Springer eBooks · doi:10.1007/978-3-030-53176-8_30 · Cited by 4
Herpes viruses and neuroinflammation: PET imaging and implication in schizophrenia
Doorduin, J. (2010) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 4
Neuroglia in neurodegeneration: Amyotrophic lateral sclerosis and frontotemporal dementia
Marchi, F. D., Spinelli, E. G., & Bendotti, C. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19102-2.00004-1 · Cited by 4
Nonfluent-Agrammatic Variant Primary Progressive Aphasia
Roytman, M., Gordon, M. L., & Franceschi, A. M. (2021) · Springer eBooks · doi:10.1007/978-3-030-82367-2_29 · Cited by 3
Cell autonomous microglia defects in a stem cell model of frontotemporal dementiaPreprint
Iyer, A. K., Vermunt, L., Mirfakhar, F. S., Minaya, M., Acquarone, M., Koppisetti, R. K., Renganathan, A., You, S., Danhash, E., Verbeck, A. C., et al. (2024) · medRxiv · doi:10.1101/2024.05.15.24307444 · Cited by 3
Guo, S., Jin, H., Sun, H., Huang, S., Chen, Y., Chang, Y., Zhang, Y., Ding, L., Chen, S., Fu, C., et al. (2026) · EMBO Molecular Medicine · doi:10.1038/s44321-026-00394-9 · Cited by 3
“Brain sections were incubated with 3% H 2 O 2 for 25 min to inhibit endogenous peroxidase, then blocked with 3% BSA with 0.3% Triton X-100 and 1% goat serum for 60 min and incubated with primary antibodies overnight at 4 °C. Subsequently, The paper explained Problem TAR DNA-binding protein-43 (TDP-43) pathology, chara…”
InfluentialPET Imaging of Translocator Protein Expression in Neurological Disorders
Brooks, D. J. (2014) · Springer eBooks · doi:10.1007/978-3-642-42014-6_22 · Cited by 2
Turner, M. R., & Pagani, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-53168-3_27 · Cited by 2
Alfaifi, B., Tuisku, J., Matilainen, M., Anton-Rodriguez, J., Lewis, D., Jackson, A., Coope, D., Airas, L., Deakin, B., Herholz, K., et al. (2025) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1177/0271678x251348790 · Cited by 1
Diagnosis of Dementia Using Nuclear Medicine Imaging Modalities
Merissa, N., Garrett, M., & Scott, P. J. H. (2011) · InTech eBooks · doi:10.5772/25283 · Cited by 2
Approach to the diagnosis of FTD
Dickerson, B. C. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781316091586.011 · Cited by 2
Evaluation of reference tissue models for analysing [11C](R)-PK11195 studies
Kropholler, M. A., van Berckel, B. N. M., Schuitemaker, A., Folkersma, H., Luurtsema, G., Windhorst, A. D., Boellaard, R., & Lammertsma, A. A. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9591524.0642 · Cited by 1
Turner, M. R. (2014) · Springer eBooks · doi:10.1007/978-3-642-54307-4_29 · Cited by 1
Biomarkers in Disease Diagnosis and Treatment
Hoffmann, R. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-4384-8_17
The Impact of Genetic Polymorphisms on Neuroreceptor Imaging
Willeit, M., Kasper, S. F., & Praschak-Rieder, N. (2014) · Springer eBooks · doi:10.1007/978-3-642-42014-6_6
“Expression of TSPO has been studied as a marker of microglia activation and inflammation in various disorders, including Alzheimer’s disease, multiple sclerosis, front-temporal dementia and schizophrenia (Debruyne et al. 2002; Cagnin et al. 2004; Edison et al. 2008; Kreisl et al. 2012) using a variety of TSPO radiolig…”
BackgroundAmyloid imaging in Alzheimer´s disease and mild cognitive impairment by Positron Emission Tomography
Forsberg, A. (2008) · Figshare
Constable, C. (2013) · The Sydney eScholarship Repository (The University of Sydney)
PET Imaging in Neuroinflammation
Brooks, D. J. (2014) · Springer eBooks · doi:10.1007/978-3-319-08046-8_9
Activated Microglia After Traumatic Brain Injury. The Neuroinflammatory Mastermind
Folkersma, I. H. (2015) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)
Imagingof frontotemporal dementia
Rohrer, J. D. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781316091586.013
Neural Substrates of Parkinson's Disease
Koshimori, Y. (2016) · TSpace (University of Toronto)
Graf, I., Willeit, M., Kasper, S. F., & Praschak-Rieder, N. (2020) · Springer eBooks · doi:10.1007/978-3-030-53176-8_6 · Cited by 1
Ghosh, S., Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., & O’Banion, M. K. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.10.430570
“Along those lines prominent microglial activation is present in the FTD brain as detected by PET (Cagnin et al. 2004), and parallels disease pathogenesis in PSP and CBD brains (Ishizawa and Dickson 2001).”
BackgroundRevista Brasileira de Psiquiatria
Benadiba, M., Luurtsema, G., Wichert‐Ana, L., Buchpiguel, C. A., & Busatto, G. F. (2012)
(2023) · Advances in magnetic resonance technology and applications · doi:10.1016/b978-0-323-91771-1.00026-5
Immune dysregulation and neurodegenerative diseases
Cipollini, V., Troili, F., & Giubilei, F. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85841-0.00015-8
Su, Y. R., Chu, M. K., Wang, H., Wu, L., & Gao, Y. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.25.625321
Fluid and Imaging Markers of Glial Reactivity
Suárez‐Calvet, M. (2025) · Springer eBooks · doi:10.1007/978-3-031-80849-4_6
Woollacott, I., Toomey, C. E., Strand, C., Courtney, R. J., Benson, B. C., Rohrer, J. D., & Lashley, T. (2020) · Figshare · doi:10.6084/m9.figshare.12788931
Woollacott, I., Toomey, C. E., Strand, C., Courtney, R. J., Benson, B. C., Rohrer, J. D., & Lashley, T. (2020) · Figshare · doi:10.6084/m9.figshare.12788937
Chu, M., Wen, L., Jiang, D., Liu, L., Nan, H., Yue, A., Wang, Y., Wang, Y., Qu, M., Wang, N., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22621133
Arlicot, N. (2009) · doi:10.70675/8c4fde33z9347z4619z9a5fz312d47055e8b
“…d’Alzheimer 5 37 20 MCI (Cagnin et al 2001a) (Tomasi et al 2008) (Edison et al 2008) (Wiley et al 2009) (Okello et al 2009) Démence fronto-temporale 1 5 (Cagnin et al 2004) Sclérose latérale amyotrophique 1 10 (Turner et al 2004) Schizophrénie 1 10 (van Berckel et al 2008) Chorée de…”
Étude de la composante neuroinflammatoire dans les DFT/SLA
Smeyers, J. (2020) · theses.fr (ABES) · doi:10.70675/219cfa6fz5b3az4198z9deczdfaad3cd784c
Russell, K. A., Shahrabi, A. A., Akerman, S. C., Byrne, M. D., Rothstein, J. D., Trotti, D., Jensen, B. K., & Haeusler, A. R. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02341-8
BindingDB (2012) · UC San Diego · doi:10.7270/q2222vp0
Metadata
- Authors
- Cagnin, A., Rossor, M., Sampson, E. L., MacKinnon, T., & Banati, R. B.
- Affiliations
- University of Padua (IT)
- National Hospital for Neurology and Neurosurgery (GB)
- Hammersmith Hospital (GB)
- The University of Sydney (AU)
- Corresponding author
- Banati, Richard B.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2004-11-23
- Volume
- 56
- Issue
- 6
- Pages
- 894-897
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2067897311
- Cited by
- 187
- References
- 10
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 14 · 2022: 7 · 2021: 11 · 2020: 22 · 2019: 13 · 2018: 7 · 2017: 16 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 7 · 2012: 7
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- microglial activation, frontotemporal lobar degeneration, frontotemporal dementia, [11C]PK11195, translocator protein (TSPO), positron emission tomography, glial response, neurodegeneration, amyloid plaques
- MeSH terms
- Aged, Dementia, Follow-Up Studies, Humans, Isoquinolines, Middle Aged, Protein Binding, Chi-Square Distribution, Microglia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
