PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET

Venneti, Sriram; Lopresti, Brian J.; Wang, Guoji; Hamilton, Ronald L.; Mathis, Chester A.; Klunk, William E.; Apte, Udayan M.; Wiley, Clayton A.

doi:10.1016/j.neurobiolaging.2007.11.005

Cited by 138Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET

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Venneti, Sriram, Lopresti, Brian J., Wang, Guoji, Hamilton, Ronald L., Mathis, Chester A., Klunk, William E., Apte, Udayan M., Wiley, Clayton A.·2009·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2007.11.005PMC PMC2745919

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Abstract

Activated microglia may promote neurodegeneration in Alzheimer's disease (AD) and may also help in amyloid clearance in immunization therapies. In vivo imaging of activated microglia using positron emission tomography (PET) could assist in defining the role of activated microglia during AD progression and therapeutics. We hypothesized that PK11195, a ligand that binds activated microglia, could label these cells in postmortem AD tissues and in vivo in an animal model of AD using PET. [(3)H](R)-PK11195 binding was significantly higher in AD frontal cortex compared to controls and correlated mainly with the abundance of immunohistochemically labeled activated microglia. With age, the brains of APP/PS1 transgenic mice showed progressive increase in [(3)H](R)-PK11195 binding and [(11)C](R)-PK11195 retention in vivo assessed using microPET, which correlated with the histopathological abundance of activated microglia. These results suggest that PK11195 binding in AD postmortem tissue and transgenic mice in vivo correlates with the extent of microglial activation and may help define the role of activated microglia in the pathogenesis and treatment of AD.

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It is generally accepted that microglia and macrophages are the primary cell types exhibiting an increased number of TSPO binding sites in human pathologies, and that astrocytes are not significant contributors to increased TSPO binding sites.
“It is generally accepted that microglia and macrophages are the primary cell types exhibiting an increased number of TSPO binding sites in human pathologies, and that astrocytes are not significant contributors to increased TSPO binding sites [44;45].”
From Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain (2009) · cites this paper as [44]
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Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160 · see citing works
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990 · see citing works
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., et al. (2000) · Nature Medicine · doi:10.1038/78682 · Cited by 2,012 · see citing works
Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report
Nicoll, J. A. R., Wilkinson, D., Holmes, C., Steart, P., Markham, H., & Weller, R. O. (2003) · Nature Medicine · doi:10.1038/nm840 · Cited by 1,397 · see citing works
Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease
Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265 · see citing works
Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease
Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239 · see citing works
Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease
in 't Veld, B. A., Ruitenberg, A., Hofman, A., Launer, L. J., van Duijn, C. M., Stijnen, T., Breteler, M. M. B., & Stricker, B. H. C. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010178 · Cited by 1,196 · see citing works
Risk of Alzheimer's disease and duration of NSAID use
Stewart, W. F., Kawas, C., Corrada, M., & Metter, E. J. (1997) · Neurology · doi:10.1212/wnl.48.3.626 · Cited by 1,132 · see citing works
In-vivo measurement of activated microglia in dementia
Cagnin, A., Brooks, D. J., Kennedy, A. M., Gunn, R. N., Myers, R., Turkheimer, F. E., Jones, T., & Banati, R. B. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05625-2 · Cited by 1,054 · see citing works
Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins
Borchelt, D. R., Ratovitski, T., van Lare, J., Lee, M. K., Gonzales, V., Jenkins, N. A., Copeland, N. G., Price, D. L., & Sisodia, S. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80974-5 · Cited by 1,023 · see citing works
MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES
González-Scarano, F., & Baltuch, G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.219 · Cited by 984 · see citing works
Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease
Kitazawa, M., Oddo, S., Yamasaki, T. R., Green, K. N., & LaFerla, F. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2868-05.2005 · Cited by 697 · see citing works
The peripheral benzodiazepine binding site in the brain in multiple sclerosis
Banati, R. B., Newcombe, J., Gunn, R. N., Cagnin, A., Turkheimer, F., Heppner, F., Price, G., Wegner, F., Giovannoni, G., Miller, D. H., et al. (2000) · Brain · doi:10.1093/brain/123.11.2321 · Cited by 661 · see citing works
Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease
Ferrer, I., Boada, M., Guerra, M. L. S., Rey, M. J., & Costa‐Jussà, F. R. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00493.x · Cited by 567 · see citing works
Binding of the Positron Emission Tomography Tracer Pittsburgh Compound-B Reflects the Amount of Amyloid-β in Alzheimer's Disease Brain But Not in Transgenic Mouse Brain
Klunk, W. E., Lopresti, B. J., Ikonomović, M. D., Lefterov, I. M., Koldamova, R. P., Abrahamson, E. E., Debnath, M. L., Holt, D. P., Huang, G.-F., Shao, L., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2990-05.2005 · Cited by 376 · see citing works
Self-citation
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Masliah, E., Hansen, L., Adame, A., Crews, L. A., Bard, F., Lee, C., Seubert, P. A., Games, D., Kirby, L., & Schenk, D. (2005) · Neurology · doi:10.1212/01.wnl.0000148590.39911.df · Cited by 355 · see citing works
Microglial Activation Resulting from CD40-CD40L Interaction After β-Amyloid Stimulation
Tan, J., Town, T., Paris, D., Mori, T., Suo, Z., Crawford, F., Mattson, M. P., Flavell, R. A., & MULLAN, M. J. (1999) · Science · doi:10.1126/science.286.5448.2352 · Cited by 352 · see citing works
Association of Microglia with Amyloid Plaques in Brains of APP23 Transgenic Mice
Stalder, M., Phinney, A., Probst, A., Sommer, B., Staufenbiel, M., & Jucker, M. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65423-5 · Cited by 345 · see citing works
β-Amyloid Activates the O⨪2 Forming NADPH Oxidase in Microglia, Monocytes, and Neutrophils
Della Bianca, V., Dusi, S., Bianchini, E., Dal Prà, I., & Rossi, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.22.15493 · Cited by 324 · see citing works
Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to β-amyloid deposition in APP/PS1 double transgenic Alzheimer mice
Malm, T. M., Koistinaho, M., Pärepalo, M., Vatanen, T., Ooka, A., Karlsson, S., & Koistinaho, J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.009 · Cited by 301 · see citing works
PK (‘peripheral benzodiazepine’) – binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK 11195 binding to activated microglia
Banati, R. B., Myers, R., & Kreutzberg, G. W. (1997) · Journal of Neurocytology · doi:10.1023/a:1018567510105 · Cited by 299 · see citing works
Passive Amyloid Immunotherapy Clears Amyloid and Transiently Activates Microglia in a Transgenic Mouse Model of Amyloid Deposition
Wilcock, D. M., Rojiani, A. M., Rosenthal, A., Levkowitz, G., Subbarao, S., Alamed, J., Wilson, D. H., Wilson, N., Freeman, M. J., Gordon, M. N., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1090-04.2004 · Cited by 298 · see citing works
Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat
Stephenson, D., Schober, D. A., Smalstig, E. B., Mincy, R. E., Gehlert, D. R., & Clemens, J. A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-05263.1995 · Cited by 220 · see citing works
Cellular and Subcellular Localization of Peripheral Benzodiazepine Receptors After Trimethyltin Neurotoxicity
Kuhlmann, A. C., & Guilarte, T. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741694.x · Cited by 215 · see citing works
Immunological aspects of microglia: relevance to Alzheimer's disease
Benveniste, E. N., Nguyen, V. T., & O'Keefe, G. M. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00045-6 · Cited by 188 · see citing works
Traumatic brain injury leads to increased expression of peripheral-type benzodiazepine receptors, neuronal death, and activation of astrocytes and microglia in rat thalamus.
Rao, V. L. R., Dogan, A., Bowen, K., & Dempsey, R. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7269 · Cited by 183 · see citing works
Macrophage and Astrocyte Populations in Relation to [ 3 H]PK 11195 Binding in Rat Cerebral Cortex following a Local Ischaemic Lesion
Myers, R., Manjil, L. G., Cullen, B. M., Price, G. W., Frackowiak, R. S. J., & Cremer, J. E. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.64 · Cited by 182 · see citing works
Dynamic Complexity of the Microglial Activation Response in Transgenic Models of Amyloid Deposition: Implications for Alzheimer Therapeutics
Morgan, D., Gordon, M. N., Tan, J., Wilcock, D. M., & Rojiani, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000178444.33972.e0 · Cited by 174 · see citing works
Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization
Chen, M., Baidoo, K. E., Verina, T., & Guilarte, T. R. (2004) · Brain · doi:10.1093/brain/awh161 · Cited by 136 · see citing works
Untitled work
(1995) · PubMed · Cited by 122 · see citing works
Microglial interaction with β‐amyloid: Implications for the pathogenesis of Alzheimer's disease
Bamberger, M. E., & Landreth, G. E. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1121 · Cited by 71 · see citing works
PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS
Venneti, S., Lopresti, B. J., Wang, G., Bissel, S. J., Mathis, C. A., MELTZER, C. C., Boada, F. E., Capuano, S., Kress, G. J., Davis, D. K., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20227 · Cited by 53 · see citing works
Self-citation
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Dickson, D. W. (1999) · American Journal of Pathology · doi:10.1016/s0002-9440(10)65416-8 · Cited by 46 · see citing works
The role of microglia in Alzheimer’s disease: friend or foe?
Schenk, D., & Yednock, T. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00034-9 · Cited by 32 · see citing works
Up‐regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain
Pedersen, M. D., Minuzzi, L., Wirenfeldt, M., Meldgaard, M., Slidsborg, C., Cumming, P. D., & Finsen, B. R. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04975.x · Cited by 26 · see citing works
Effects of Rofecoxib or Naproxen vs Placebo on Alzheimer Disease Progression: A Randomized Controlled Trial
Aisen, P. S., Schafer, K. A., Grundman, M., Pfeiffer, E., Sano, M., Davis, K. L., Farlow, M. R., Jin, S., Thomas, R. G., Thal, L. J., et al. (2003) · JAMA · doi:10.1001/jama.289.21.2819 · Cited by 5 · see citing works
A Free Community Approach to Classifying Disease
Graeber, M. B., Lowe, J. S., & Radotra, B. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010016 · Cited by 2 · see citing works
Untitled work
(1997) · doi:10.1002/(sici)1097-4547(19971015)50:2

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Uddin, M. S., Kabir, M. T., Jalouli, M., Rahman, M. A., Jeandet, P., Behl, T., Alexiou, A. T., Albadrani, G. M., Abdel‐Daim, M. M., Perveen, A., et al. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210826130210 · Cited by 76 · see citing works
PET imaging of neuroinflammation in a rat traumatic brain injury model with radiolabeled TSPO ligand DPA-714
Wang, Y., Yue, X., Kiesewetter, D. O., Niu, G., Teng, G., & Chen, X. S. (2014) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-014-2727-5 · Cited by 77 · see citing works
[18F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease
James, M. L., Belichenko, N. P., Shuhendler, A. J., Höhne, A., Andrews, L., Condon, C., Nguyen, T. V., Reiser, V., Jones, P. A., Trigg, W., et al. (2017) · Theranostics · doi:10.7150/thno.17666 · Cited by 73 · see citing works
Neuroinflammation in healthy aging: A PET study using a novel Translocator Protein 18kDa (TSPO) radioligand, [18F]-FEPPA
Suridjan, I., Rusjan, P. M., Voineskos, A. N., Selvanathan, T., Setiawan, E., Strafella, A. P., Wilson, A. A., Meyer, J. H., Houle, S., & Mizrahi, R. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.09.021 · Cited by 71 · see citing works
Diagnostic and Therapeutic Potential of TSPO Studies Regarding Neurodegenerative Diseases, Psychiatric Disorders, Alcohol Use Disorders, Traumatic Brain Injury, and Stroke: An Update
Dimitrova‐Shumkovska, J., Krstanoski, L., & Veenman, L. (2020) · Cells · doi:10.3390/cells9040870 · Cited by 70 · see citing works
Chronic Treatment with 50 mg/kg Cannabidiol Improves Cognition and Moderately Reduces Aβ40 Levels in 12-Month-Old Male AβPPswe/PS1ΔE9 Transgenic Mice
Watt, G., Shang, K., Zieba, J., Olaya, J. C., Li, H., Garner, B., & Karl, T. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191242 · Cited by 68 · see citing works
Microglial toll-like receptors and Alzheimer’s disease
Su, F., Bai, F., Zhou, H., & Zhang, Z. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.10.010 · Cited by 67 · see citing works
Neuroinflammation PET imaging of the translocator protein (TSPO) in Alzheimer's disease: An update
Gouilly, D., Saint‐Aubert, L., Ribeiro, M. J., Salabert, A., Tauber, C., Péran, P., Arlicot, N., Pariente, J., & Payoux, P. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15613 · Cited by 66 · see citing works
Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18 F-FDG and 18 F-DPA-714 PET imaging
Helin, J. S., Lopez‐Picon, F. R., Majidi, R. A., Eskola, O., Krzyczmonik, A., Keller, T., Löyttyniemi, E., Solin, O. H., Rinne, J. O., & Haaparanta‐Solin, M. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16677990 · Cited by 66 · see citing works
Astrocytic TSPO upregulation appears before microglial TSPO in Alzheimer’s disease
Tournier, B. B., Tsartsalis, S., Ceyzériat, K., Fraser, B. H., Grégoire, M.-C., Kövari, E., & Millet, P. (2020) · Journal of Alzheimer’s Disease · doi:10.3233/jad-200136 · Cited by 65 · see citing works
Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders
Virdee, K., Cumming, P. D., Caprioli, D., Jupp, B., Rominger, A., Aigbirhio, F. I., Fryer, T. D., Riss, P. J., & Dalley, J. W. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.01.009 · Cited by 60 · see citing works
TSPO and amyloid deposits in sub-regions of the hippocampus in the 3xTgAD mouse model of Alzheimer’s disease
Tournier, B. B., Tsartsalis, S., Rigaud, D., Fossey, C., Cailly, T., Fabis, F., Pham, T., Grégoire, M.-C., Kövari, E., Moulin-Sallanon, M., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.09.022 · Cited by 62 · see citing works
PET Imaging for Early Detection of Alzheimer’s Disease
Bao, W., Jia, H., Finnema, S. J., Cai, Z., Carson, R. E., & Huang, Y. H. (2017) · PET Clinics · doi:10.1016/j.cpet.2017.03.001 · Cited by 54 · see citing works
Imaging microglial activation and glucose consumption in a mouse model of Alzheimer's disease
Rapic, S., Backes, H., Viel, T., Kummer, M. P., Monfared, P., Neumaier, B., Vollmar, S., Hoehn, M., der Linden, A. V., Heneka, M. T., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.04.016 · Cited by 52 · see citing works
PET Imaging of Translocator Protein (18 kDa) in a Mouse Model of Alzheimer's Disease UsingN-(2,5-Dimethoxybenzyl)-2-18F-Fluoro-N-(2-Phenoxyphenyl)Acetamide
James, M. L., Belichenko, N. P., Nguyen, T. V., Andrews, L., Ding, Z., Liu, H., Bodapati, D., Arksey, N., Shen, B., Cheng, Z., et al. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.114.141648 · Cited by 52 · see citing works
[18F]FEPPA a TSPO Radioligand: Optimized Radiosynthesis and Evaluation as a PET Radiotracer for Brain Inflammation in a Peripheral LPS-Injected Mouse Model
Vignal, N., Cisternino, S., Rizzo-Padoin, N., San, C., Hontonnou, F., Gelé, T., Declèves, X., Sarda‐Mantel, L., & Hosten, B. (2018) · Molecules · doi:10.3390/molecules23061375 · Cited by 51 · see citing works
Amyloid load and translocator protein 18 kDa in APPswePS1-dE9 mice: a longitudinal study
Sérrière, S., Tauber, C., Vercouillie, J., Mothes, C., Pruckner, C., Guilloteau, D., Kassiou, M., Doméné, A., Garreau, L., Page, G., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.11.023 · Cited by 49 · see citing works
Fluorescence-activated cell sorting to reveal the cell origin of radioligand binding
Tournier, B., Tsartsalis, S., Ceyzériat, K., Medina, Z., Fraser, B. H., Grégoire, M., Kövari, E., & Millet, P. (2020) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1177/0271678x19860408 · Cited by 42 · see citing works
Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis
Pal, A., Rani, I., Pawar, A. T., Picozza, M., Rongioletti, M. C. A., & Squitti, R. (2021) · Biomolecules · doi:10.3390/biom11111598 · Cited by 47 · see citing works
The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: an update
Bales, K. R. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2012.666234 · Cited by 45 · see citing works
In vitro Characterization of the Regional Binding Distribution of Amyloid PET Tracer Florbetaben and the Glia Tracers Deprenyl and PK11195 in Autopsy Alzheimer’s Brain Tissue
Ni, R., Röjdner, J., Voytenko, L., Dyrks, T., Thiele, A., Marutle, A., & Nordberg, A. (2021) · Journal of Alzheimer's Disease · doi:10.3233/jad-201344 · Cited by 35 · see citing works
βCTF-Correlated Burst of Hippocampal TNFα Occurs at a Very Early, Pre-Plaque Stage in the TgCRND8 Mouse Model of Alzheimer's Disease
Cavanagh, C., Colby-Milley, J., Bouvier, D. S., Farso, M. C., Chabot, J., Quirion, R., & Krantic, S. M. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122131 · Cited by 42 · see citing works
[11C]PK11195 PET imaging of spinal glial activation after nerve injury in rats
Imamoto, N., Momosaki, S., Fujita, M., Omachi, S., Yamato, H., Kimura, M., Kanegawa, N., Shinohara, S., & Abe, K. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.039 · Cited by 42 · see citing works
Neurosteroid Metabolites of Gonadal Steroid Hormones in Neuroprotection: Implications for Sex Differences in Neurodegenerative Disease
Mendell, A. L., & MacLusky, N. J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00359 · Cited by 41 · see citing works
Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer’s Disease Patients
Metaxas, A., Thygesen, C., Briting, S. R. R., Landau, A. M., Darvesh, S., & Finsen, B. R. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00538 · Cited by 41 · see citing works
Evaluation of neuroprotective effect of glucagon‐like peptide 1 analogs using neuroimaging
Femminella, G. D., & Edison, P. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.12.012 · Cited by 41 · see citing works
Normobaric hyperoxia markedly reduces brain damage and sensorimotor deficits following brief focal ischaemia
Ejaz, S., Emmrich, J., Sitnikov, S., Hong, Y. T., Sawiak, S. J., Fryer, T. D., Aigbirhio, F. I., Williamson, D. J., & Baron, J. (2016) · Brain · doi:10.1093/brain/awv391 · Cited by 40 · see citing works
Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice
Kelso, M. L., Scheff, S. W., Pauly, J. R., & Loftin, C. D. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-108 · Cited by 40 · see citing works
Imaging Neuroinflammation – from Bench to Bedside
Pulli, B. (2014) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000226 · Cited by 39 · see citing works
A microPET study of the regional distribution of [11C]-PK11195 binding following temporary focal cerebral ischemia in the rat. Correlation with post mortem mapping of microglia activation
Hughes, J. L., Jones, P. S., Beech, J. S., Wang, D., Menon, D. K., Aigbirhio, F. I., Fryer, T. D., & Baron, J. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.060 · Cited by 39 · see citing works
MicroPET imaging and transgenic models: a blueprint for Alzheimer's disease clinical research
Zimmer, E. R., Parent, M. J., Cuello, A. C., Gauthier, S. G., & Rosa‐Neto, P. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.07.002 · Cited by 37 · see citing works
Longitudinal translocator protein-18 kDa–positron emission tomography imaging of peripheral and central myeloid cells in a mouse model of complex regional pain syndrome
Cropper, H. C., Johnson, E. M., Haight, E. S., Cordonnier, S. A., Chaney, A. M., Forman, T. E., Biswal, A., Stevens, M. Y., James, M. L., & Tawfik, V. L. (2019) · Pain · doi:10.1097/j.pain.0000000000001607 · Cited by 37 · see citing works
Longitudinal investigation of neuroinflammation and metabolite profiles in the APP swe× PS 1Δe9 transgenic mouse model of Alzheimer's disease
Chaney, A. M., Bauer, M., Bochicchio, D., Smigova, A., Kassiou, M., Davies, K. E., Williams, S. R., & Boutin, H. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14251 · Cited by 37 · see citing works
[ 11 C]PBR28 PET Imaging is Sensitive to Neuroinflammation in the Aged Rat
Walker, M. D., Dinelle, K., Kornelsen, R. A., Lee, N. V., Miao, Q., Adam, M., Takhar, C., Mak, E., Schulzer, M., Farrer, M. J., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.54 · Cited by 35 · see citing works
Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET
Barron, A. M., Tokunaga, M., Zhang, M., Ji, B., Suhara, T., & Higuchi, M. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0700-x · Cited by 36 · see citing works
Current neuroimaging techniques in Alzheimer's disease and applications in animal models.
Zhang, L., Chang, R. C., Chu, L., & Mak, H. K. (2012) · Europe PMC (PubMed Central) · Cited by 31 · see citing works
Heterogeneity of Microglia Phenotypes: Developmental, Functional and Some Therapeutic Considerations
Yuan, Y., Wu, C., & Ling, E. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190722114248 · Cited by 30 · see citing works
APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly
Snellman, A., Ekblad, L. L., Tuisku, J., Koivumäki, M., Ashton, N. J., Lantero‐Rodriguez, J., Karikari, T. K., Helin, S., Bucci, M., Löyttyniemi, E., et al. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01209-6 · Cited by 30 · see citing works
Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression
Teipel, S. J., Buchert, R., Thome, J., Hampel, H. J., & Pahnke, J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.004 · Cited by 29 · see citing works
The translocator protein (18 kDa) and its role in neuropsychiatric disorders
Barichello, T., Simões, L. R., Collodel, A., Giridharan, V. V., Dal‐Pizzol, F., Macêdo, D. S., & Quevedo, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.010 · Cited by 29 · see citing works
Alzheimer's disease biomarkers: correspondence between human studies and animal models
Sabbagh, J. J., Kinney, J. W., & Cummings, J. L. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.04.010 · Cited by 27 · see citing works
[64Cu]Cu-ATSM: an emerging theranostic agent for cancer and neuroinflammation
Xie, F., & Wei, W. (2022) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-022-05887-6 · Cited by 26 · see citing works
Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review
Woodcock, E. A., Hillmer, A. T., Mason, G. F., & Cosgrove, K. (2019) · Complex Psychiatry · doi:10.1159/000499621 · Cited by 25 · see citing works
Alzheimer's disease biomarkers in animal models: closing the translational gap.
Sabbagh, J. J., Kinney, J. W., & Cummings, J. L. (2013) · Europe PMC (PubMed Central) · Cited by 24 · see citing works
PET Imaging for Dynamically Monitoring Neuroinflammation in APP/PS1 Mouse Model Using [18F]DPA714
Hu, W., Pan, D., Wang, Y., Bao, W., Zuo, C., Guan, Y., Hua, F., Yang, M., & Zhao, J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00810 · Cited by 22 · see citing works
Spinal microglial activation in rat models of neuropathic and osteoarthritic pain: An autoradiographic study using [ 3H]PK 11195
Miller, T. R., Wetter, J. B., Jarvis, M. F., & Bitner, R. S. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00232.x · Cited by 22 · see citing works
Heterogeneity of Neuroinflammatory Responses in Amyotrophic Lateral Sclerosis: A Challenge or an Opportunity?
Cipollina, G., Serej, A. D., Nolfi, G. D., Gazzano, A., Marsala, A., Spatafora, M. G., & Peviani, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217923 · Cited by 20 · see citing works
Autoradiographical imaging of PPARγ agonist effects on PBR/TSPO binding in TASTPM mice
Roberts, J. C., Friel, S. L., Roman, S. A., Perren, M. J., Harper, A. J., Davis, J. B., Richardson, J. C., Virley, D. J., & Medhurst, A. D. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.01.002 · Cited by 21 · see citing works
Differential effects of age on human striatal adenosine A1and A2Areceptors
Mishina, M., Kimura, Y., Naganawa, M., Ishii, K., Oda, K., Sakata, M., Toyohara, J., Kobayashi, S., Katayama, Y., & Ishiwata, K. (2012) · Synapse · doi:10.1002/syn.21573 · Cited by 20 · see citing works
Quantitative imaging of neuroinflammation in human white matter: A positron emission tomography study with translocator protein 18 kDa radioligand, [18F]‐FEPPA
Suridjan, I., Rusjan, P., Kenk, M., Verhoeff, N. P. L. G., Voineskos, A. N., Rotenberg, D. J., Wilson, A. A., Meyer, J. H., Houle, S., & Mizrahi, R. (2014) · Synapse · doi:10.1002/syn.21765 · Cited by 20 · see citing works
The translocator protein as a drug target in Alzheimer’s disease
Chua, S. W., Kassiou, M., & Ittner, L. M. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.896201 · Cited by 20 · see citing works
In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: Insights from neuroimaging research in humans and rodent models
Higuchi, M., Maeda, J., Ji, B., Maruyama, M., Okauchi, T., Tokunaga, M., Ono, M., & Suhara, T. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.01.003 · Cited by 20 · see citing works
Reprint of: Microglial toll-like receptors and Alzheimer’s disease
Su, F., Bai, F., Zhou, H., & Zhang, Z. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.05.016 · Cited by 19 · see citing works
Amyloid-β Immunotherapy Reduces Amyloid Plaques and Astroglial Reaction in Aged Domestic Dogs
Bosch, M. N., Pugliese, M., Andrade, C., Gimeno‐Bayón, J., Mahy, N., & Rodríguez, M. J. (2014) · Neurodegenerative Diseases · doi:10.1159/000368672 · Cited by 19 · see citing works
Unveiling Molecular Events in the Brain by Noninvasive Imaging
Klohs, J., & Rudin, M. (2011) · The Neuroscientist · doi:10.1177/1073858410383433 · Cited by 22 · see citing works
Positron Emission Tomography in Animal Models of Alzheimer’s Disease Amyloidosis: Translational Implications
Ni, R. (2021) · Pharmaceuticals · doi:10.3390/ph14111179 · Cited by 18 · see citing works
Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies
Tong, J., Williams, B., Rusjan, P., Mizrahi, R., Lacapere, J., McCluskey, T., Furukawa, Y., Guttman, M., Ang, L., Boileau, I., et al. (2020) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1177/0271678x19858003 · Cited by 14 · see citing works
The Role of Glia in Wilson’s Disease: Clinical, Neuroimaging, Neuropathological and Molecular Perspectives
Gromadzka, G., Wilkaniec, A., Tarnacka, B., Hadrian, K., Bendykowska, M., Przybyłkowski, A., & Litwin, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147545 · Cited by 15 · see citing works
Imaging neuroinflammation in Alzheimer’s and other dementias: recent advances and future directions
Brooks, D. J. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.01.049 · Cited by 17 · see citing works
Alzheimer's disease and type 2 diabetes: Two diseases, one common link?
Bartl, J., Monoranu, C., Schilling, A.-K., Kolter, J. F., Riederer, P., & Grünblatt, E. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.650204 · Cited by 17 · see citing works
Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia
Yu, Z., Sakai, M., Fukushima, H., Ono, C., Kikuchi, Y., Koyama, R., Matsui, K., Furuyashiki, T., Kida, S., & Tomita, H. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.08.017 · Cited by 16 · see citing works
Beyond monoamines: I. Novel targets and radiotracers for Positron emission tomography imaging in psychiatric disorders
Lopresti, B. J., Royse, S. K., Mathis, C. A., Tollefson, S., & Narendran, R. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15615 · Cited by 16 · see citing works
Self-citation
Mouse models of neurodegenerative disease: preclinical imaging and neurovascular component
Albanese, S., Greco, A., Auletta, L., & Mancini, M. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9770-3 · Cited by 16 · see citing works
Relationship Between Reactive Astrocytes, by [18F]SMBT-1 Imaging, with Amyloid-Beta, Tau, Glucose Metabolism, and TSPO in Mouse Models of Alzheimer’s Disease
Kong, Y., Maschio, C., Shi, X., Yao, B., Xie, F., Zuo, C., Konietzko, U., Shi, K., Rominger, A., Xiao, J., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04106-7 · Cited by 17 · see citing works

P2–312: PET imaging of microglia in a mouse model of Alzheimer's disease
Venneti, S., Lopresti, B. J., Wang, G., Mathis, C. A., Klunk, W. E., Shmookler, A. D., Hamilton, R. L., Apte, U. M., & Wiley, C. A. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.1152
Self-citation
Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study
Schuitemaker, A., Kropholler, M. A., Boellaard, R., van der Flier, W. M., Kloet, R. W., van der Doef, T. F., Knol, D. L., Windhorst, A. D., Luurtsema, G., Barkhof, F., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.04.021 · Cited by 167 · see citing works
Imaging microglial activation and glucose consumption in a mouse model of Alzheimer's disease
Rapic, S., Backes, H., Viel, T., Kummer, M. P., Monfared, P., Neumaier, B., Vollmar, S., Hoehn, M., der Linden, A. V., Heneka, M. T., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.04.016 · Cited by 52 · see citing works
In-vivo measurement of activated microglia in dementia
Cagnin, A., Brooks, D. J., Kennedy, A. M., Gunn, R. N., Myers, R., Turkheimer, F. E., Jones, T., & Banati, R. B. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05625-2 · Cited by 1,054 · see citing works
O1–03–01: Microglial activation in patients with mild cognitive impairment and Alzheimer's disease: A study using [11C](R)–PK11195 and PET
Schuitemaker, A., van Berckel, B. N. M., Boellaard, R., Kropholler, M. A., Lubberink, M., Jonker, C., Lammertsma, A. A., & Scheltens, P. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.044

Authors: Venneti, S., Lopresti, B. J., Wang, G., Hamilton, R. L., Mathis, C. A., Klunk, W. E., Apte, U. M., & Wiley, C. A.
Affiliations: University of Pittsburgh (US)
Corresponding author: Wiley, Clayton A.
ORCID: Venneti, Sriram
Lopresti, Brian J.
Wang, Guoji
Hamilton, Ronald L.
Mathis, Chester A.
Klunk, William E.
Apte, Udayan M.
Wiley, Clayton A.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2009-08
Volume: 30
Issue: 8
Pages: 1217-1226
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2007.11.005
PMC: PMC2745919
OpenAlex: W2011239875
Cited by: 138
References: 39
Citations by year: 2025: 3 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 9 · 2020: 11 · 2019: 9 · 2018: 9 · 2017: 11 · 2016: 8 · 2015: 10 · 2014: 13 · 2013: 7 · 2012: 13
FWCI: 3.96
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: University of Pittsburgh
National Institutes of Health
National Institute on Aging (R21AG025829, P50AG005133, R01AG020226, P50 AG05133-21)
National Institute of Mental Health (R01 MH-64921, K24 MH01717, R01MH064921, K24MH001717, R01MH071151)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: PK11195, activated microglia, Alzheimer's disease, positron emission tomography, APP/PS1 mice, microglial activation, amyloid clearance, neurodegeneration, frontal cortex, radioligand binding, in vivo imaging
MeSH terms: Aged, Aged, 80 and over, Aging, Alzheimer Disease, Animals, Astrocytes, Brain, Disease Models, Animal, Female, Frontal Lobe, Humans, Isoquinolines, Male, Mice, Transgenic, Receptors, Cell Surface, Tritium, Amyloid beta-Protein Precursor, Microglia, Disease Progression, Positron-Emission Tomography, Mice, Presenilin-1, Protease Nexins

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PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET

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