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In vivo detection of microglial activation in frontotemporal dementia
Open accessAbstract
Using positron emission tomography and [(11)C](R)-PK11195, a marker of "peripheral benzodiazepine sites" that is upregulated on activated microglia during progressive tissue pathology, we show increased binding of [(11)C](R)-PK11195 in frontotemporal lobar degeneration in the typically affected frontotemporal brain regions. This implies the presence of an active glial response reflecting progressive neuronal degeneration. It also suggests that increased [(11)C](R)-PK11195 binding, previously demonstrated for Alzheimer's disease, may occur independently from increased amyloid plaque formation, given that it is not a characteristic feature of frontotemporal lobar degeneration.
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“In vivo PET studies320,321 and immunohistochemistry studies322–324 have found increased microglial activation in the frontal and temporal cortices of patients with FTD.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [320]
Citations
Cites
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047
In-vivo measurement of activated microglia in dementia
Cagnin, A., Brooks, D. J., Kennedy, A. M., Gunn, R. N., Myers, R., Turkheimer, F. E., Jones, T., & Banati, R. B. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05625-2 · Cited by 1,054
Self-citationThe peripheral benzodiazepine binding site in the brain in multiple sclerosis
Banati, R. B., Newcombe, J., Gunn, R. N., Cagnin, A., Turkheimer, F., Heppner, F., Price, G., Wegner, F., Giovannoni, G., Miller, D. H., et al. (2000) · Brain · doi:10.1093/brain/123.11.2321 · Cited by 661
Self-citationBruyn, R. P. M. (2003) · Clinical Neurology and Neurosurgery · doi:10.1016/s0303-8467(02)00110-5 · Cited by 510
Thalamic microglial activation in ischemic stroke detected in vivo by PET and [ 11 C]PK11195
Pappatà, S., Levasseur, M., Gunn, R. N., Myers, R., Crouzel, C., Syrota, A., Jones, T., Kreutzberg, G. W., & Banati, R. B. (2000) · Neurology · doi:10.1212/wnl.55.7.1052 · Cited by 252
Self-citationMyers, R., Manjil, L. G., Cullen, B. M., Price, G. W., Frackowiak, R. S. J., & Cremer, J. E. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.64 · Cited by 182
Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD
Rosen, H., Hartikainen, K. M., Jagust, W., Kramer, J. H., Reed, B., Cummings, J. L., Boone, K., Ellis, W. G., Miller, C. A., & Miller, B. L. (2002) · Neurology · doi:10.1212/wnl.58.11.1608 · Cited by 175
The neuropathology and biochemistry of frontotemporal dementia
Muñoz, D. G., Dickson, D. W., Bergeron, C., Mackenzie, I. R., Delacourte, A., & Zhukareva, V. A. (2003) · Annals of Neurology · doi:10.1002/ana.10571 · Cited by 83
Microglial reaction in Pick's disease
Paulus, W., Bancher, C., & Jellinger, K. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90147-d · Cited by 42
Pick body disease and Pick syndrome*
Uchihara, T., Ikeda, K., & Tsuchiya, K. (2003) · Neuropathology · doi:10.1046/j.1440-1789.2003.00523.x · Cited by 33
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Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Gao, C., Jiang, J., Tan, Y., & Chen, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01588-0 · Cited by 1,616
“…in TBK1 are associated with developing FTD, 317,318 and variants in TREM2 increase an individual ’ s risk of developing FTD. 319 In vivo PET studies 320,321 and immunohistochemistry studies 322 – 324 have found increased microglial activation in the frontal and temporal cortices of patients with…”
BackgroundInnate immune activation in neurodegenerative disease
Heneka, M. T., Kummer, M. P., & Latz, E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3705 · Cited by 1,437
Rupprecht, R., Papadopoulos, V., Rammes, G., Baghai, T. C., Fan, J., Akula, N., Groyer, G., Adams, D., & Schumacher, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3295 · Cited by 930
Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response
Bachiller, S., Jiménez-Ferrer, I., Paulus, A., Yang, Y., Swanberg, M., Deierborg, T., & Boza‐Serrano, A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00488 · Cited by 750
Neuroinflammation as a common feature of neurodegenerative disorders
Guzman-Martinez, L., Maccioni, R. B., Andrade, V., Navarrete, L. P., Pastor, M. G., & Ramos-Escobar, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01008 · Cited by 702
“In this way, the neuroinflammatory process has been proposed as possible diagnostic tools, through in vivo uptake of the microglia, using positron emission tomography (PET) images with the translocator protein (TSPO) ligand [11C]-PK11195 in the FTD and other tauopathies (Cagnin et al., 2004; Venneti et al., 2009; Zhan…”
Method
Metadata
- Authors
- Cagnin, A., Rossor, M., Sampson, E. L., MacKinnon, T., & Banati, R. B.
- Affiliations
- University of Padua (IT)
- National Hospital for Neurology and Neurosurgery (GB)
- Hammersmith Hospital (GB)
- The University of Sydney (AU)
- Corresponding author
- Banati, Richard B.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2004-11-23
- Volume
- 56
- Issue
- 6
- Pages
- 894-897
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2067897311
- Cited by
- 187
- References
- 10
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 14 · 2022: 7 · 2021: 11 · 2020: 22 · 2019: 13 · 2018: 7 · 2017: 16 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 7 · 2012: 7
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- microglial activation, frontotemporal lobar degeneration, frontotemporal dementia, [11C]PK11195, translocator protein (TSPO), positron emission tomography, glial response, neurodegeneration, amyloid plaques
- MeSH terms
- Aged, Dementia, Follow-Up Studies, Humans, Isoquinolines, Middle Aged, Protein Binding, Chi-Square Distribution, Microglia
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