The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Interleukin‐1β contributes to the generation of experimental febrile seizures
Open accessAbstract
Fever can provoke “febrile” seizures (FS). Because complex FS may promote development of temporal lobe epilepsy, understanding their mechanisms is clinically important. Using an immature rodent model and transgenic technology, we examined the role of interleukin‐1β, (IL‐1β), a pyrogenic, proinflammatory cytokine, in FS. IL‐1β receptor–deficient mice were resistant to experimental FS. This resistance appeared independent of genetic background and was attributed to lack of IL‐1β signaling, because exogenous cytokine reduced seizure threshold in wild‐type but not receptor‐deficient mice independent of strain. In addition, high IL‐1β doses induced seizures only in IL‐1β receptor–expressing mice. These data indicate that IL‐1β signaling contributes critically to fever‐induced hyperexcitability underlying FS, constituting a potential target for their prevention. Ann Neurol 2005;57:152–155 An Erratum has been published for this article in Ann Neurol 57: 609, 2005.
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Viviani, B., Bartesaghi, S., Gardoni, F., Vezzani, A., Behrens, M. M., Bartfai, T., Binaglia, M., Corsini, E., Di Luca, M., Galli, C. L., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08692.2003 · Cited by 893
Self-citationThe Prevalence and Incidence of Convulsive Disorders in Children
Hauser, W. A. (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb05932.x · Cited by 684
Vezzani, A., Conti, M., De Luigi, A., Ravizza, T., Moneta, D., Marchesi, F., & De Simoni, M. G. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05054.1999 · Cited by 584
Self-citationSchauwecker, P. E., & Steward, O. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4103 · Cited by 506
Cytokines as Endogenous Pyrogens
Dinarello, C. A. (1999) · The Journal of Infectious Diseases · doi:10.1086/513856 · Cited by 387
Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice
Labow, M., Shuster, D., Zetterstrom, M., Nunes, P., Terry, R., Cullinan, E. B., Bartfai, T., Solorzano, C., Moldawer, L. L., Chizzonite, R., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.5.2452 · Cited by 330
Self-citationInterleukin-1 Receptors in Mouse Brain:Characterization and Neuronal Localization
TAKAO, T., TRACEY, D. E., MITCHELL, W. M., & DE, E. B. S. (1990) · Endocrinology · doi:10.1210/endo-127-6-3070 · Cited by 290
Knockout mice: simple solutions to the problems of genetic background and flanking genes
Wolfer, D. P., Crusio, W. E., & Lipp, H.-P. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02192-6 · Cited by 270
Kanemoto, K., Kawasaki, J., Miyamoto, T., Obayashi, H., & Nishimura, M. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200005)47:5<571::aid-ana3>3.0.co;2-a · Cited by 263
Ichiyama, T., Nishikawa, M., Yoshitomi, T., Hayashi, T., & Furukawa, S. (1998) · Neurology · doi:10.1212/wnl.50.2.407 · Cited by 167
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Vezzani, A., French, J., Bartfai, T., & Baram, T. Z. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.178 · Cited by 1,876
Self-citationRavizza, T., Gagliardi, B., Noé, F., Boer, K., Aronica, E., & Vezzani, A. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.08.012 · Cited by 699
Self-citationEpilepsy and brain inflammation
Vezzani, A., Aronica, E., Mazarati, A., & Pittman, Q. J. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.033 · Cited by 603
Self-citationThe role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective
Shaftel, S. S., Griffin, W. S. T., & O'Banion, M. K. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-7 · Cited by 565
Targa Dias Anastacio, H., Matosin, N., & Ooi, L. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02024-7 · Cited by 401
Metadata
- Authors
- Dubé, C., Vezzani, A., Behrens, M., Bartfai, T., & Baram, T. Z.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2004-12-27
- Volume
- 57
- Issue
- 1
- Pages
- 152-155
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2167121498
- Cited by
- 423
- References
- 18
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- green
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