The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cytokines as Endogenous Pyrogens
Abstract
Cytokines are pleiotropic molecules mediating several pathologic processes. Long before the discovery of cytokines as immune system growth factors or as bone marrow stimulants, investigators learned a great deal about cytokines when they studied them as the endogenous mediators of fever. The terms "granulocytic" or "endogenous pyrogen" were used to describe substances with the biologic property of fever induction. Today, we recognize that pyrogenicity is a fundamental biologic property of several cytokines and hence the clinically recognizeable property of fever links host perturbations during disease with fundamental perturbations in cell biology. In this review, the discoveries made on endogenous pyrogens are revisited, with insights into the importance of the earlier work to the present-day understanding of cytokines in health and in disease.
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Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
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Suppression of fever after lesions of the anteroventral third ventricle in guinea pigs
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Cited by
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073
The who's who of T ‐cell differentiation: Human memory T ‐cell subsets
Mahnke, Y. D., Brodie, T. M., Sallusto, F., Roederer, M., & Lugli, E. (2013) · European Journal of Immunology · doi:10.1002/eji.201343751 · Cited by 817
Interleukin‐1β contributes to the generation of experimental febrile seizures
Dubé, C., Vezzani, A., Behrens, M., Bartfai, T., & Baram, T. Z. (2005) · Annals of Neurology · doi:10.1002/ana.20358 · Cited by 423
The role of IL-1 in the pathogenesis of heart disease
Bujak, M., & Frangogiannis, N. G. (2009) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-009-0024-y · Cited by 307
Metadata
- Authors
- Dinarello, C. A.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03
- Volume
- 179
- Issue
- s2
- Pages
- S294-S304
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2141498118
- Cited by
- 387
- References
- 5
- FWCI
- 14.51
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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