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Nrf2—a therapeutic target for the treatment of neurodegenerative diseases

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Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

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The IL-1β phenomena in neuroinflammatory diseases

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Cellular infiltration in traumatic brain injury

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Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment

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Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach

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The Nrf2–ARE cytoprotective pathway in astrocytes

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Oxidative stress and β-amyloid protein in Alzheimer’s disease

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Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer’s Disease

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SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β

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Cytokines in CAR T Cell–Associated Neurotoxicity

Gust, J., Ponce, R. A., Liles, W. C., Garden, G. A., & Turtle, C. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.577027 · Cited by 268 · see citing works

Emerging Roles for the Immune System in Traumatic Brain Injury

McKee, C. A., & Lukens, J. R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00556 · Cited by 265 · see citing works

microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF).

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Rodent models of neuroinflammation for Alzheimer’s disease

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The Nrf2-ARE Pathway: A Valuable Therapeutic Target for the Treatment of Neurodegenerative Diseases

Gururaj Joshi, A., & Johnson, J. A. (2012) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488912803252023 · Cited by 246 · see citing works

IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases

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Cathepsin B plays a critical role in inducing Alzheimer’s disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice

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The Link between Oxidative Stress, Mitochondrial Dysfunction and Neuroinflammation in the Pathophysiology of Alzheimer’s Disease: Therapeutic Implications and Future Perspectives

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PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

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Inhibition of NADPH oxidase promotes alternative and anti‐inflammatory microglial activation during neuroinflammation

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Increased Serum IL-1β Level in Alzheimer’s Disease and Mild Cognitive Impairment

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Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities

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Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats: Adolescent Sugar Intake Impairs Spatial Memory

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Metabolic Inflammation—A Role for Hepatic Inflammatory Pathways as Drivers of Comorbidities in Nonalcoholic Fatty Liver Disease?

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Toll-like receptor (TLR) and inflammasome actions in the central nervous system

Hanamsagar, R., Hanke, M. L., & Kielian, T. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.03.001 · Cited by 203 · see citing works

Peripheral inflammatory biomarkers in Alzheimer’s disease: a brief review

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Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents

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Innate Immunity and Neuroinflammation

Shastri, A., Bonifati, D. M., & Kishore, U. (2013) · Mediators of Inflammation · doi:10.1155/2013/342931 · Cited by 201 · see citing works

The role of inflammasome in Alzheimer's disease

Liu, L., & Chan, C. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2013.12.007 · Cited by 192 · see citing works

Inflammasome signaling at the heart of central nervous system pathology

Chakraborty, S., Kaushik, D. K., Gupta, M., & Basu, A. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22343 · Cited by 186 · see citing works

IL1β Induces Mesenchymal Stem Cells Migration and Leucocyte Chemotaxis Through NF-κB

Carrero, R., Cerrada, I., Lledó, E., Dopazo, J., Garcia‐García, F., Rubio, M., Trigueros, C., Dorronsoro, A., Ruiz‐Saurí, A., Montero, J., et al. (2012) · Stem Cell Reviews and Reports · doi:10.1007/s12015-012-9364-9 · Cited by 184 · see citing works

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease

Dionisio-Santos, D. A., Olschowka, J. A., & O’Banion, M. K. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1453-0 · Cited by 184 · see citing works

Impaired insulin signalling and allostatic load in Alzheimer disease

Felice, F. G. D., Gonçalves, R. A., & Ferreira, S. T. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00558-9 · Cited by 180 · see citing works

Tai Chi Improves Cognition and Plasma BDNF in Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial

Sungkarat, S., Boripuntakul, S., Kumfu, S., Lord, S., & Chattipakorn, N. (2018) · Neurorehabilitation and Neural Repair · doi:10.1177/1545968317753682 · Cited by 167 · see citing works

IL-1 family cytokines trigger sterile inflammatory disease

Lukens, J. R., Gross, J. M., & Kanneganti, T. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00315 · Cited by 172 · see citing works

Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease

Ting, K. K., Brew, B. J., & Guillemin, G. J. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-36 · Cited by 166 · see citing works

Sustained expression of interleukin-1β in mouse hippocampus impairs spatial memory

Moore, A. H., Wu, M., Shaftel, S. S., Graham, K. A., & O’Banion, M. K. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.073 · Cited by 159 · see citing works

Mechanisms of Oxidative Damage in Multiple Sclerosis and Neurodegenerative Diseases: Therapeutic Modulation via Fumaric Acid Esters

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Electrochemical immunosensor for simultaneous determination of interleukin-1 beta and tumor necrosis factor alpha in serum and saliva using dual screen printed electrodes modified with functionalized double–walled carbon nanotubes

Sánchez‐Tirado, E., Salvo, C., González-Cortés, A., Yáñez‐Sedeño, P., Langa, F., & Pingarrón, J. M. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2016.12.034 · Cited by 159 · see citing works

Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer’s Disease Patients, Possible Biomarkers for Early Diagnosis

Grimaldi, A., Pediconi, N., Oieni, F., Pizzarelli, R., Rosito, M., Giubettini, M., Santini, T., Limatola, C., Ruocco, G., Ragozzino, D., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00925 · Cited by 153 · see citing works

IL-1β induces rod degeneration through the disruption of retinal glutamate homeostasis

Charles‐Messance, H., Blot, G., Couturier, A., Vignaud, L., Touhami, S., Béguier, F., Siqueiros‐Márquez, L., Forster, V., Barmo, N., Augustin, S., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1655-5 · Cited by 154 · see citing works

Circulating levels of IL-1 family cytokines and receptors in Alzheimer’s disease: new markers of disease progression?

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Neuroinflammation as a Factor of Neurodegenerative Disease: Thalidomide Analogs as Treatments

Jung, Y. J., Tweedie, D., Scerba, M. T., & Greig, N. H. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00313 · Cited by 154 · see citing works

ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease

Evans, C. E., Miners, J. S., Piva, G., Willis, C. L., Heard, D. M., Kidd, E. J., Good, M. A., & Kehoe, P. G. (2020) · Acta Neuropathologica · doi:10.1007/s00401-019-02098-6 · Cited by 143 · see citing works

Alterations in Immune Cells and Mediators in the Brain: It's Not Always Neuroinflammation!

Estes, M. L., & McAllister, A. K. (2014) · Brain Pathology · doi:10.1111/bpa.12198 · Cited by 145 · see citing works

Peripheral Cytokines and Chemokines in Alzheimer’s Disease

Lee, K. S., Chung, J. H., Choi, T.-K., Suh, S. Y., Oh, B. H., & Hong, C. H. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000245156 · Cited by 140 · see citing works

Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events

Bhaskar, K., Maphis, N. M., Xu, G., Varvel, N. H., Kokiko‐Cochran, O. N., Weick, J. P., Staugaitis, S. M., Cardona, A. E., Ransohoff, R. M., Herrup, K., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.007 · Cited by 138 · see citing works

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

Masters, S. L., & O'Neill, L. A. J. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.01.005 · Cited by 134 · see citing works

1α,25-Dihydroxyvitamin D3 and Resolvin D1 Retune the Balance between Amyloid-β Phagocytosis and Inflammation in Alzheimer's Disease Patients

Mizwicki, M. T., Liu, G., Fiala, M., Magpantay, L. I., Sayre, J. W., Siani, A., Mahanian, M., Weitzman, R. E., Hayden, E. Y., Rosenthal, M. J., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121735 · Cited by 135 · see citing works

Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment

Chakrabarti, S., Kumar Khemka, V., Banerjee, A., Chatterjee, G., Ganguly, A., & Biswas, A. (2015) · Aging and disease · doi:10.14336/ad.2014.002 · Cited by 134 · see citing works

Caffeine Protects Against Disruptions of the Blood-Brain Barrier in Animal Models of Alzheimer's and Parkinson's Diseases

Chen, X., Ghribi, O., & Geiger, J. D. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1376 · Cited by 133 · see citing works

The IL-1 family cytokines and receptors in autoimmune diseases

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SIMVASTATIN ATTENUATES MICROGLIAL CELLS AND ASTROCYTE ACTIVATION AND DECREASES INTERLEUKIN-1B LEVEL AFTER TRAUMATIC BRAIN INJURY

Li, B., Mahmood, A., Lu, D., Wu, H., Xiong, Y., Qu, C., & Chopp, M. (2009) · Neurosurgery · doi:10.1227/01.neu.0000346272.76537.dc · Cited by 133 · see citing works

Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore

Monif, M., Reid, C. A., Powell, K. L., Drummond, K., O’Brien, T. J., & Williams, D. A. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0621-8 · Cited by 129 · see citing works

Neuronal Mitochondria Modulation of LPS-Induced Neuroinflammation

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Neuronal death in Alzheimer’s disease and therapeutic opportunities

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Targeting innate immunity for neurodegenerative disorders of the central nervous system

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BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer’s Disease Pathology

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Cardiovascular comorbidities, inflammation, and cerebral small vessel disease

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Inflammation and Anti-Inflammatory Strategies for Alzheimer’s Disease – A Mini-Review

McNaull, B., Todd, S., McGuinness, B., & Passmore, A. (2009) · Gerontology · doi:10.1159/000237873 · Cited by 120 · see citing works

Toll-Like Receptor 2 and NLRP3 Cooperate To Recognize a Functional Bacterial Amyloid, Curli

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Interleukin-1β in Central Nervous System Injury and Repair.

Hewett, S. J., Jackman, N. A., & Claycomb, R. (2012) · PubMed · Cited by 121 · see citing works

The Obese Brain: Mechanisms of Systemic and Local Inflammation, and Interventions to Reverse the Cognitive Deficit

Salas-Venegas, V., Flores-Torres, R. P., Rodríguez-Cortés, Y. M., Rodríguez-Retana, D., Carreto, R. J. R., Concepción-Carrillo, L. E., Pérez-Flores, L. J., Alarcón‐Aguilar, A., López‐Díazguerrero, N. E., Gómez‐González, B., et al. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.798995 · Cited by 118 · see citing works

Assessing the contribution of inflammation in models of Alzheimer's disease

Johnston, H. R., Boutin, H., & Allan, S. M. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390886 · Cited by 112 · see citing works

Thioredoxin-Interacting Protein (TXNIP) Associated NLRP3 Inflammasome Activation in Human Alzheimer’s Disease Brain

Li, L., Ismael, S., Nasoohi, S., Sakata, K., Liao, F., McDonald, M. P., & Ishrat, T. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180814 · Cited by 113 · see citing works

Adverse Oral Health and Cognitive Decline: The Health, Aging and Body Composition Study

Stewart, R. J., Weyant, R. J., Garcia, M. E., Harris, T. B., Launer, L. J., Satterfield, S., Simonsick, E. M., Yaffe, K. S., & Newman, A. B. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12094 · Cited by 110 · see citing works

Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction in a Mouse Model That Exhibits Age-Dependent Progression of Alzheimer's Disease-Related Pathology

Bachstetter, A. D., Norris, C. M., Sompol, P. M., Wilcock, D. M., Goulding, D. S., Neltner, J. H., Clair, D. K. S., Watterson, D. M., & Eldik, L. J. V. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1496-12.2012 · Cited by 105 · see citing works

Purinergic receptors as potential therapeutic targets in Alzheimer's disease

Woods, L. T., Ajit, D., Camden, J. M., Erb, L., & Weisman, G. A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.031 · Cited by 106 · see citing works

Neuroinflammation, myelin and behavior: Temporal patterns following mild traumatic brain injury in mice

Taib, T., Leconte, C., Steenwinckel, J. V., Cho, A. H., Palmier, B., Torsello, E., Lai–Kuen, R., Onyeomah, S., Ecomard, K., Benedetto, C., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184811 · Cited by 105 · see citing works

New Insights into Neuroinflammation Involved in Pathogenic Mechanism of Alzheimer’s Disease and Its Potential for Therapeutic Intervention

Li, T., Lu, L., Pember, E., Li, X., Zhang, B., & Zhu, Z. (2022) · Cells · doi:10.3390/cells11121925 · Cited by 109 · see citing works

Expression Profiles of Cytokines in the Brains of Alzheimer's Disease (AD) Patients Compared to the Brains of Non-Demented Patients with and without Increasing AD Pathology

Morimoto, K., Horio, J., Satoh, H., Sue, L. I., Beach, T. G., Arita, S., Tooyama, I., & Konishi, Y. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101815 · Cited by 105 · see citing works

Interleukin-1β induces an inflammatory response and the breakdown of the endothelial cell layer in an improved human THBMEC-based in vitro blood–brain barrier model

Labus, J., Häckel, S., Lucka, L., & Danker, K. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.03.002 · Cited by 104 · see citing works

Acetate supplementation modulates brain histone acetylation and decreases interleukin-1β expression in a rat model of neuroinflammation

Soliman, M. L., Smith, M. D., Houdek, H. M., & Rosenberger, T. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-51 · Cited by 105 · see citing works

Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine

Fresta, C. G., Fidilio, A., Lazzarino, G., Musso, N., Grasso, M., Merlo, S., Amorini, A. M., Bucolo, C., Tavazzi, B., Lazzarino, G., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030776 · Cited by 99 · see citing works

Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)

Qin, P., Sun, Y., & Li, L. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5371 · Cited by 104 · see citing works

Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice

Babcock, A. A., Ilkjær, L., Clausen, B. H., Villadsen, B., Dissing-Olesen, L., Bendixen, A. T. M., Lyck, L., Lambertsen, K. L., & Finsen, B. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.006 · Cited by 107 · see citing works

Aluminum chloride induces neuroinflammation, loss of neuronal dendritic spine and cognition impairment in developing rat

Cao, Z., Yang, X., Zhang, H., Wang, H., Huang, W., Xu, F., Zhuang, C., Wang, X., & Li, Y. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.02.092 · Cited by 98 · see citing works

Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice

Latta, C. H., Sudduth, T. L., Weekman, E. M., Brothers, H. M., Abner, E. L., Popa, G. J., Mendenhall, M. D., Gonzalez-Oregon, F., Braun, K. J., & Wilcock, D. M. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0243-6 · Cited by 95 · see citing works

Farnesol quells oxidative stress, reactive gliosis and inflammation during acrylamide-induced neurotoxicity: Behavioral and biochemical evidence

Santhanasabapathy, R., Vasudevan, S., Anupriya, K., Pabitha, R., & Sudhandiran, G. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.067 · Cited by 96 · see citing works

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

Couturier, J., Stancu, I., Schakman, O., Pierrot, N., Huaux, F., Kienlen-Campard, P., Dewachter, I., & Octave, J. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0477-y · Cited by 92 · see citing works

Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease

Terzioglu, G., & Young-Pearse, T. L. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00674-9 · Cited by 95 · see citing works

Upregulation of P2RX7 inCx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1β Secretion and Photoreceptor Neurodegeneration

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