The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Nogo‐A antibody improves regeneration and locomotion of spinal cord–injured rats
Abstract
Spinal cord trauma leads to loss of motor, sensory and autonomic functions below the lesion. Recovery is very restricted, due in part to neurite growth inhibitory myelin proteins, in particular Nogo‐A. Two neutralizing antibodies against Nogo‐A were used to study recovery and axonal regeneration after spinal cord lesions. Three months old Lewis rats were tested in sensory‐motor tasks (open field locomotion, crossing of ladder rungs and narrow beams, the CatWalk® runway, reactions to heat and von Frey hairs). A T‐shaped lesion was made at T8, and an intrathecal catheter delivered highly purified anti‐Nogo‐A monoclonal IgGs or unspecific IgGs for 2 weeks. A better outcome in motor behavior was obtained as early as two weeks after lesion in the animals receiving the Nogo‐A antibodies. Withdrawal responses to heat and mechanical stimuli were not different between the groups. Histology showed enhanced regeneration of corticospinal axons in the anti‐Nogo‐A antibody groups. fMRI revealed significant cortical responses to stimulation of the hindpaw exclusively in anti‐Nogo‐A animals. These results demonstrate that neutralization of the neurite growth inhibitor Nogo‐A by intrathecal antibodies leads to enhanced regeneration and reorganization of the injured CNS, resulting in improved recovery of compromised functions in the absence of dysfunctions. Ann Neurol 2005
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Cites
A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats
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Self-citationSchnell, L., & Schwab, M. E. (1990) · Nature · doi:10.1038/343269a0 · Cited by 1,222
Self-citationIdentification of a receptor mediating Nogo-66 inhibition of axonal regeneration
Fournier, A. E., GrandPre, T., & Strittmatter, S. M. (2001) · Nature · doi:10.1038/35053072 · Cited by 1,080
Caroni, P., & Schwab, M. E. (1988) · Neuron · doi:10.1016/0896-6273(88)90212-7 · Cited by 884
Self-citationMyelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
Filbin, M. T. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1195 · Cited by 871
Plasticity of motor systems after incomplete spinal cord injury
Raineteau, O., & Schwab, M. E. (2001) · Nature Reviews Neuroscience · doi:10.1038/35067570 · Cited by 803
Self-citationRecovery from spinal cord injury mediated by antibodies to neurite growth inhibitors
Bregman, B. S., Kunkel-Bagden, E., Schnell, L., Dai, H. N., Gao, D., & Schwab, M. E. (1995) · Nature · doi:10.1038/378498a0 · Cited by 716
Self-citationNogo-66 receptor antagonist peptide promotes axonal regeneration
GrandPré, T., Li, S., & Strittmatter, S. M. (2002) · Nature · doi:10.1038/417547a · Cited by 711
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Cited by
Freund, P., Schmidlin, E., Wannier, T., Bloch, J., Mir, A., Schwab, M. E., & Rouiller, E. M. (2006) · Nature Medicine · doi:10.1038/nm1436 · Cited by 335
Self-citationPetratos, S., Li, Q.-X., George, A. J., Hou, X., Kerr, M. L., Unabia, S. E., Hatzinisiriou, I., Maksel, D., Aguilar, M.-I., & Small, D. H. (2008) · Brain · doi:10.1093/brain/awm260 · Cited by 197
A sulfated carbohydrate epitope inhibits axon regeneration after injury
Brown, J. M., Xia, J., Zhuang, B., Cho, K.-S., Rogers, C. J., Gama, C. I., Rawat, M., Tully, S. E., Uetani, N., Mason, D. E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121318109 · Cited by 154
Delayed anti-Nogo-A therapy improves function after chronic stroke in adult rats
Tsai, S.-Y., Papadopoulos, C. M., Schwab, M. E., & Kartje, G. L. (2011) · Stroke · doi:10.1161/strokeaha.110.590083 · Cited by 106
Self-citationRole of Nogo-A in neuronal survival in the reperfused ischemic brain
Kilic, E., ElAli, A., Kilic, Ü., Guo, Z., Ugur, M., Uslu, U., Bassetti, C. L., Schwab, M. E., & Hermann, D. M. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.268 · Cited by 79
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Metadata
- Authors
- Liebscher, T., Schnell, L., Schnell, D., Scholl, J., Schneider, R., Gullo, M., Fouad, K., Mir, A., Rausch, M., Kindler, D., Hamers, F. P. T., & Schwab, M. E.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2005-09-19
- Volume
- 58
- Issue
- 5
- Pages
- 706-719
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2035616055
- Cited by
- 351
- References
- 39
- FWCI
- 12.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liebscher, T., Schnell, L., Schnell, D., Scholl, J., Schneider, R., Gullo, M., Fouad, K., Mir, A., Rausch, M., Kindler, D., Hamers, F. P. T., & Schwab, M. E. (2005). Nogo‐A antibody improves regeneration and locomotion of spinal cord–injured rats. Annals of Neurology. https://doi.org/10.1002/ana.20627
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