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Cited by 524Epilepsy research and treatmentSuicide and Self-Harm StudiesElectroconvulsive Therapy Studies

The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.

Depression and suicide attempt as risk factors for incident unprovoked seizures

Hesdorffer, Dale C., Hauser, W. Allen, Olafsson, Elias, Ludvigsson, Petur, Kjartansson, Olafur·2006·Annals of Neurology
DOI 10.1002/ana.20685
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Abstract

Major depression has been shown to increase the risk for development of epilepsy, but prior studies have not evaluated whether this is due to specific symptoms of depression. We conducted a population‐based case–control study of all newly diagnosed unprovoked seizures among Icelandic children and adults aged 10 years and older to test the hypothesis that major depression is a risk factor for developing unprovoked seizure and epilepsy, and to address whether specific symptoms of depression account for this increased risk. Cases were matched to the next two same sex births from the population registry. Using standardized interviews, we ascertained symptoms of major depression to make a Diagnostic and Statistical Manual, Fourth Edition (DSM‐IV) diagnosis. A history of major depression was 1.7‐fold more common among cases than among controls (95% confidence interval, 1.1–2.7). A history of attempted suicide was 5.1‐fold more common among cases than among controls (95% confidence interval, 2.2–11.5). Attempted suicide increased seizure risk even after adjusting for age, sex, cumulative alcohol intake, and major depression or number of symptoms of depression. Major depression and attempted suicide independently increase the risk for unprovoked seizure. These data suggest that depression and suicide attempt may be due to different underlying neurochemical pathways, each of which is important in the development of epilepsy. Ann Neurol 2005

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Research works printed but not linked: 4

  1. Trimble MR, 1980, Epilepsy and behavior '79, 118
  2. Kogeogorgos J, 1991, Psychiatric symptom patterns of chronic epileptics attending a neurologic clinic: a controlled investigation, Br J Psychiatry, 30, 236
  3. 1997, Diagnostic and statistical manual of mental disorders
  4. First MB, 1999, Structured clinical interview for DSM‐IV Axis I disorders. Research version

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Metadata

Authors
Hesdorffer, D. C., Hauser, W. A., Olafsson, E., Ludvigsson, P., & Kjartansson, O.
Affiliations
Columbia University (US)
Corresponding author
Hesdorffer, Dale C.
ORCID
Venue
Annals of Neurology
Publisher
Wiley
Published
2005-12-22
Volume
59
Issue
1
Pages
35-41
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.20685
OpenAlex
W1991938716
Cited by
524
References
37
Citations by year
2026: 10 · 2025: 4 · 2024: 29 · 2023: 14 · 2022: 19 · 2021: 28 · 2020: 18 · 2019: 20 · 2018: 23 · 2017: 32 · 2016: 29 · 2015: 31 · 2014: 41 · 2013: 33 · 2012: 38
FWCI
12.03
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Hirsla (Landspítali University Hospital) (submittedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS032663, 5R01 NS 32663)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords
major depressive disorder, suicide attempts, unprovoked seizures, epilepsy, seizure risk factors, depressive symptoms, neurochemical pathways, alcohol consumption
MeSH terms
Adolescent, Adult, Child, Depression, Epilepsy, Female, Humans, Iceland, Male, Middle Aged, Risk Factors, Seizures, Suicide, Attempted

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