The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Depression and suicide attempt as risk factors for incident unprovoked seizures
Abstract
Major depression has been shown to increase the risk for development of epilepsy, but prior studies have not evaluated whether this is due to specific symptoms of depression. We conducted a population‐based case–control study of all newly diagnosed unprovoked seizures among Icelandic children and adults aged 10 years and older to test the hypothesis that major depression is a risk factor for developing unprovoked seizure and epilepsy, and to address whether specific symptoms of depression account for this increased risk. Cases were matched to the next two same sex births from the population registry. Using standardized interviews, we ascertained symptoms of major depression to make a Diagnostic and Statistical Manual, Fourth Edition (DSM‐IV) diagnosis. A history of major depression was 1.7‐fold more common among cases than among controls (95% confidence interval, 1.1–2.7). A history of attempted suicide was 5.1‐fold more common among cases than among controls (95% confidence interval, 2.2–11.5). Attempted suicide increased seizure risk even after adjusting for age, sex, cumulative alcohol intake, and major depression or number of symptoms of depression. Major depression and attempted suicide independently increase the risk for unprovoked seizure. These data suggest that depression and suicide attempt may be due to different underlying neurochemical pathways, each of which is important in the development of epilepsy. Ann Neurol 2005
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“Both population-based and experimental studies in human and animal models have demonstrated a robust relationship between seizures and psychiatric disorders.”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [12]
Citations
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Rossi, S., Antal, A., Bestmann, S., Bikson, M., Brewer, C., Brockmöller, J., Carpenter, L. L., Cincotta, M., Chen, R., Daskalakis, J. D., et al. (2021) · Clinical Neurophysiology · doi:10.1016/j.clinph.2020.10.003 · Cited by 1,573
Standards for epidemiologic studies and surveillance of epilepsy
Thurman, D. J., Beghi, E., Begley, C. E., Berg, A. T., Buchhalter, J., Ding, D., Hesdorffer, D. C., Hauser, W. A., Kazis, L. E., Kobau, R., et al. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2011.03121.x · Cited by 1,049
Self-citationComorbidities of epilepsy: current concepts and future perspectives
Keezer, M. R., Sisodiya, S. M., & Sander, J. W. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00225-2 · Cited by 778
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Epilepsy, suicidality, and psychiatric disorders: a bidirectional association
Hesdorffer, D. C., Ishihara, L., Mynepalli, L., Webb, D. J., Weil, J., & Hauser, W. A. (2012) · Annals of Neurology · doi:10.1002/ana.23601 · Cited by 610
Self-citation
Metadata
- Authors
- Hesdorffer, D. C., Hauser, W. A., Olafsson, E., Ludvigsson, P., & Kjartansson, O.
- Affiliations
- Columbia University (US)
- Corresponding author
- Hesdorffer, Dale C.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2005-12-22
- Volume
- 59
- Issue
- 1
- Pages
- 35-41
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1991938716
- Cited by
- 524
- References
- 37
- Citations by year
- 2026: 10 · 2025: 4 · 2024: 29 · 2023: 14 · 2022: 19 · 2021: 28 · 2020: 18 · 2019: 20 · 2018: 23 · 2017: 32 · 2016: 29 · 2015: 31 · 2014: 41 · 2013: 33 · 2012: 38
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS032663, 5R01 NS 32663)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- major depressive disorder, suicide attempts, unprovoked seizures, epilepsy, seizure risk factors, depressive symptoms, neurochemical pathways, alcohol consumption
- MeSH terms
- Adolescent, Adult, Child, Depression, Epilepsy, Female, Humans, Iceland, Male, Middle Aged, Risk Factors, Seizures, Suicide, Attempted
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