Comorbidities of epilepsy: current concepts and future perspectives

Keezer, Mark R; Sisodiya, Sanjay M; Sander, Josemir W

doi:10.1016/s1474-4422(15)00225-2

Cited by 778Epilepsy research and treatmentTuberous Sclerosis Complex ResearchPharmacological Effects and Toxicity Studies

Comorbidities of epilepsy: current concepts and future perspectives

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Keezer, Mark R, Sisodiya, Sanjay M, Sander, Josemir W·2016·The Lancet Neurology

DOI 10.1016/s1474-4422(15)00225-2

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Abstract

The burden of comorbidity in people with epilepsy is high. Several diseases, including depression, anxiety, dementia, migraine, heart disease, peptic ulcers, and arthritis are up to eight times more common in people with epilepsy than in the general population. Several mechanisms explain how epilepsy and comorbidities are associated, including shared risk factors and bidirectional relations. There is a pressing need for new and validated screening instruments and guidelines to help with the early detection and treatment of comorbid conditions. Preliminary evidence suggests that some conditions, such as depression and migraine, negatively affect seizure outcome and quality of life. Further investigation is needed to explore these relations and the effects of targeted interventions. Future advances in the investigation of the comorbidities of epilepsy will strengthen our understanding of epilepsy and could play an important part in stratification for genetic studies.

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Authors: Keezer, M. R., Sisodiya, S. M., & Sander, J. W.
Affiliations: National Institute for Health and Care Research (GB)
Corresponding author: Sander, Josemir W
ORCID: Keezer, Mark R
Sisodiya, Sanjay M
Sander, Josemir W
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2016-01
Volume: 15
Issue: 1
Pages: 106-115
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(15)00225-2
OpenAlex: W2146867319
Cited by: 778
References: 95
Citations by year: 2026: 78 · 2025: 109 · 2024: 119 · 2023: 86 · 2022: 91 · 2021: 77 · 2020: 72 · 2019: 58 · 2018: 35 · 2017: 21 · 2016: 29 · 2015: 1
FWCI: 3.94
Type: journal article
Language: en
Open access: green
discovery.ucl.ac.uk
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion, cc-by-nc-nd)
Funders: National Institute for Health and Care Research
University College London
Epilepsiefonds
University College London Hospitals NHS Foundation Trust
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
Health Sciences › Medicine › Physiology › Tuberous Sclerosis Complex Research
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Keywords: epilepsy, comorbidities, depression, anxiety, dementia, migraine, cardiovascular disease, peptic ulcer, arthritis, shared risk factors, bidirectional relations, screening tool, seizure outcome, quality of life, genetic stratification
MeSH terms: Mental Disorders, Epilepsy, Forecasting, Humans, Migraine Disorders, Risk Factors, Comorbidity

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Comorbidities of epilepsy: current concepts and future perspectives

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