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APOE ε4 is not associated with Alzheimer's disease in elderly Nigerians
Open accessAbstract
Since 1992, research teams from Indiana University and the University of Ibadan have been collecting and comparing data from two diverse, elderly populations to identify risk factors for dementia and Alzheimer's disease. Apolipoprotein E (APOE) was genotyped in 2,245 Nigerian samples. Of these, 830 had a diagnosis: 459 were normal, and 140 had dementia including 123 diagnosed with Alzheimer's disease. In contrast with other populations, the APOE ε4 allele was not significantly associated with Alzheimer's disease or dementia. This lack of association in the Yoruba might reflect genetic variation, environmental factors, as well as genetic/environmental interactions. Ann neurol 2006
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“the association between ε4 and disease is reported to be weaker among African-American and Hispanic individuals [58, 61, 62] and nonexistent among Nigerian individuals [63].”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [63]
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Metadata
- Authors
- Gureje, O., Ogunniyi, A., Baiyewu, O., Price, B., Unverzagt, F. W., Evans, R. M., Smith‐Gamble, V., Lane, K. A., Gao, S., Hall, K. S., Hendrie, H. C., & Murrell, J. R.
- Affiliations
- University of Ibadan (NG)
- Indiana University Indianapolis (US)
- Indiana University School of Medicine (US)
- Corresponding author
- Murrell, Jill R.
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2005-12-22
- Volume
- 59
- Issue
- 1
- Pages
- 182-185
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC2855121
- OpenAlex
- W2160403558
- Cited by
- 139
- References
- 16
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 10 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 7 · 2013: 2 · 2012: 6
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- National Institute on Aging (P30AG010133, R01AG09956, P30 AG-10133, R01AG009956)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- APOE ε4, Alzheimer's disease, dementia, apolipoprotein E, genetic association, Yoruba, genetic variation, gene-environment interaction, risk factors
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Ethnicity, Female, Genotype, Humans, Male, Mass Screening, Nigeria, Risk Factors, Protein Isoforms
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