Cited by 139Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsGenetic Associations and Epidemiology

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APOE ε4 is not associated with Alzheimer's disease in elderly Nigerians

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Gureje, Oye, Ogunniyi, Adesola, Baiyewu, Olusegun, Price, Brandon, Unverzagt, Frederick W., Evans, Rebecca M., Smith‐Gamble, Valerie, Lane, Kathleen A., Gao, Sujuan, Hall, Kathleen S., Hendrie, Hugh C., Murrell, Jill R.·2006·Annals of Neurology

DOI 10.1002/ana.20694PMC PMC2855121

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Abstract

Since 1992, research teams from Indiana University and the University of Ibadan have been collecting and comparing data from two diverse, elderly populations to identify risk factors for dementia and Alzheimer's disease. Apolipoprotein E (APOE) was genotyped in 2,245 Nigerian samples. Of these, 830 had a diagnosis: 459 were normal, and 140 had dementia including 123 diagnosed with Alzheimer's disease. In contrast with other populations, the APOE ε4 allele was not significantly associated with Alzheimer's disease or dementia. This lack of association in the Yoruba might reflect genetic variation, environmental factors, as well as genetic/environmental interactions. Ann neurol 2006

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“…(Miyashita et al., 2013; Jun et al., 2017), whereas the association between ε4 and disease is reported to be weaker among African-American and Hispanic individuals (Farrer et al., 1997; Murrell et al., 2006; Rajabli et al., 2018) and nonexistent among Nigerian individuals (Gureje et al., 2006).”
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Authors: Gureje, O., Ogunniyi, A., Baiyewu, O., Price, B., Unverzagt, F. W., Evans, R. M., Smith‐Gamble, V., Lane, K. A., Gao, S., Hall, K. S., Hendrie, H. C., & Murrell, J. R.
Affiliations: University of Ibadan (NG)
Indiana University Indianapolis (US)
Indiana University School of Medicine (US)
Corresponding author: Murrell, Jill R.
ORCID: Gureje, Oye
Ogunniyi, Adesola
Baiyewu, Olusegun
Unverzagt, Frederick W.
Evans, Rebecca M.
Lane, Kathleen A.
Gao, Sujuan
Hendrie, Hugh C.
Murrell, Jill R.
Venue: Annals of Neurology
Publisher: Wiley
Published: 2005-12-22
Volume: 59
Issue: 1
Pages: 182-185
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.20694
PMC: PMC2855121
OpenAlex: W2160403558
Cited by: 139
References: 16
Citations by year: 2026: 6 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 10 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 7 · 2013: 2 · 2012: 6
FWCI: 4.63
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
Funders: National Institute on Aging (P30AG010133, R01AG09956, P30 AG-10133, R01AG009956)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: APOE ε4, Alzheimer's disease, dementia, apolipoprotein E, genetic association, Yoruba, genetic variation, gene-environment interaction, risk factors
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Ethnicity, Female, Genotype, Humans, Male, Mass Screening, Nigeria, Risk Factors, Protein Isoforms

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APOE ε4 is not associated with Alzheimer's disease in elderly Nigerians

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