The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Quantifying axonal loss after optic neuritis with optical coherence tomography
Abstract
Objective: To determine to what degree changes in retinal nerve fiber layer (RNFL) thickness after optic neuritis (ON) correlate with either visual recovery or impairment. Methods: ON can cause visible defects within the RNFL, which can be quantified using optical coherence tomography (OCT). It may be possible to predict visual recovery by measuring RNFL loss after ON. Fifty‐four patients underwent repeated evaluations with optical coherence tomography and standardized ophthalmic testing after ON. Regression analyses were used to determine the relationship between RNFL thickness and visual function. Results: Thinning of the RNFL was seen in the majority of patients (74%), and it tended to occur within 3 to 6 months of ON. The average RNFL value was thinner (p < 0.0001) in the affected (78μm) compared with the unaffected eye (100μm). Patients with incomplete visual recovery demonstrated greater RNFL loss after ON. Regression analyses demonstrated a threshold of RNFL thickness (75μm), below which RNFL measurements predicted persistent visual dysfunction. Interpretation: Determination of RNFL thickness may predict visual recovery after ON, and lower RNFL values correlate with impaired visual function. Optical coherence tomography may have a potential role as a surrogate marker for axonal integrity within the optic nerve among patients with ON. Ann Neurol 2006;59:963–969
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Cites
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
Cited by
Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis
Gordon-Lipkin, E., Chodkowski, B., Reich, D. S., Smith, S. A., Pulicken, M., Balcer, L. J., Frohman, E. M., Cutter, G., & Calabresi, P. A. (2007) · Neurology · doi:10.1212/01.wnl.0000295995.46586.ae · Cited by 419
Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis
Talman, L. S., Bisker, E. R., Sackel, D. J., Long, D. A., Galetta, K. M., Ratchford, J. N., Lile, D. J., Farrell, S. K., Loguidice, M. J., Remington, G., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22005 · Cited by 366
Microcystic macular oedema in multiple sclerosis is associated with disease severity
Gelfand, J. M., Nolan, R., Schwartz, D. M., Graves, J., & Green, A. J. (2012) · Brain · doi:10.1093/brain/aws098 · Cited by 331
Optical coherence tomography: a window into the mechanisms of multiple sclerosis
Frohman, E. M., Fujimoto, J. G., Frohman, T. C., Calabresi, P. A., Cutter, G., & Balcer, L. J. (2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0950 · Cited by 326
Sechi, E., Cacciaguerra, L., Chen, J. J., Mariotto, S., Fadda, G., Dinoto, A., Lopez-Chiriboga, A. S., Pittock, S. J., & Flanagan, E. P. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.885218 · Cited by 325
Metadata
- Authors
- Costello, F., Coupland, S., Hodge, W., Lorello, G. R., Koroluk, J., Pan, Y. I., Freedman, M. S., Zackon, D. H., & Kardon, R. H.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2006-05-22
- Volume
- 59
- Issue
- 6
- Pages
- 963-969
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2115404493
- Cited by
- 610
- References
- 1
- FWCI
- 20.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Costello, F., Coupland, S., Hodge, W., Lorello, G. R., Koroluk, J., Pan, Y. I., Freedman, M. S., Zackon, D. H., & Kardon, R. H. (2006). Quantifying axonal loss after optic neuritis with optical coherence tomography. Annals of Neurology. https://doi.org/10.1002/ana.20851
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