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Recovery from paralysis in adult rats using embryonic stem cells
Abstract
Objective: We explored the potential of embryonic stem cell–derived motor neurons to functionally replace those cells destroyed in paralyzed adult rats. Methods: We administered a phosphodiesterase type 4 inhibitor and dibutyryl cyclic adenosine monophosphate to overcome myelin‐mediated repulsion and provided glial cell–derived neurotrophic factor within the sciatic nerve to attract transplanted embryonic stem cell–derived axons toward skeletal muscle targets. Results: We found that these strategies significantly increased the success of transplanted axons extending out of the spinal cord into ventral roots. Furthermore, transplant‐derived axons reached muscle, formed neuromuscular junctions, were physiologically active, and mediated partial recovery from paralysis. Interpretation: We conclude that restoration of functional motor units by embryonic stem cells is possible and represents a potential therapeutic strategy for patients with paralysis. To our knowledge, this is the first report of the anatomical and functional replacement of a motor neuron circuit within the adult mammalian host. Ann Neurol 2006;60:32–44
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Stem cells in human neurodegenerative disorders — time for clinical translation?
Lindvall, O., & Kokaia, Z. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40543 · Cited by 614
Lepore, A. C., Rauck, B., Dejea, C., Pardo, A. C., Rao, M. S., Rothstein, J. D., & Maragakis, N. J. (2008) · Nature Neuroscience · doi:10.1038/nn.2210 · Cited by 441
Self-citationCofano, F., Boido, M., Monticelli, M., Zenga, F., Ducati, A., Vercelli, A., & Garbossa, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112698 · Cited by 398
Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial
Mazzini, L., Ferrero, I., Luparello, V., Rustichelli, D., Gunetti, M., Mareschi, K., Testa, L., Stecco, A., Tarletti, R., Miglioretti, M., et al. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2009.08.007 · Cited by 396
Metadata
- Authors
- Deshpande, D. M., Kim, Y., Martinez, T., Carmen, J., Dike, S., Shats, I., Rubin, L. L., Drummond, J., Krishnan, C., Hoke, A., Maragakis, N., Shefner, J., Rothstein, J. D., & Kerr, D. A.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2006-06-26
- Volume
- 60
- Issue
- 1
- Pages
- 32-44
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2121904811
- Cited by
- 272
- References
- 1
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Deshpande, D. M., Kim, Y., Martinez, T., Carmen, J., Dike, S., Shats, I., Rubin, L. L., Drummond, J., Krishnan, C., Hoke, A., Maragakis, N., Shefner, J., Rothstein, J. D., & Kerr, D. A. (2006). Recovery from paralysis in adult rats using embryonic stem cells. Annals of Neurology. https://doi.org/10.1002/ana.20901
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