Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease
Open accessAbstract
Cellular abnormalities in amyotrophic lateral sclerosis (ALS) are not limited to motor neurons. Astrocyte dysfunction also occurs in human ALS and transgenic rodents expressing mutant human SOD1 protein (SOD1(G93A)). Here we investigated focal enrichment of normal astrocytes using transplantation of lineage-restricted astrocyte precursors, called glial-restricted precursors (GRPs). We transplanted GRPs around cervical spinal cord respiratory motor neuron pools, the principal cells whose dysfunction precipitates death in ALS. GRPs survived in diseased tissue, differentiated efficiently into astrocytes and reduced microgliosis in the cervical spinal cords of SOD1(G93A) rats. GRPs also extended survival and disease duration, attenuated motor neuron loss and slowed declines in forelimb motor and respiratory physiological functions. Neuroprotection was mediated in part by the primary astrocyte glutamate transporter GLT1. These findings indicate the feasibility and efficacy of transplantation-based astrocyte replacement and show that targeted multisegmental cell delivery to the cervical spinal cord is a promising therapeutic strategy for slowing focal motor neuron loss associated with ALS.
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Transplantation of wild-type astrocytes into SOD1G93A rat spinal cords was neuroprotective.
“transplantation of wild-type astrocytes into SOD1G93A rat spinal cords was neuroprotective [348]”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [348]
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Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works
Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062 · see citing works
Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation
Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143 · see citing works
Rothstein, J. D., Dykes-Hoberg, M., Pardo, C. A., Bristol, L. A., Jin, L., Kuncl, R. W., Kanai, Y., Hediger, M. A., Wang, Y., Schielke, J. P., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80086-0 · Cited by 2,534 · see citing works
Self-citationLocalization of neuronal and glial glutamate transporters
Rothstein, J. D., Martin, L. J., Levey, A. I., Dykes‐Hoberg, M., Jin, L., Wu, D. M., Nash, N. R., & Kuncl, R. W. (1994) · Neuron · doi:10.1016/0896-6273(94)90038-8 · Cited by 1,703 · see citing works
Self-citationOnset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
Boillée, S., Yamanaka, K., Lobsiger, C. S., Copeland, N. G., Jenkins, N. A., Kassiotis, G., Kollias, G., & Cleveland, D. W. (2006) · Science · doi:10.1126/science.1123511 · Cited by 1,623 · see citing works
Astrocyte activation and reactive gliosis
Pekny, M., & Nilsson, M. (2005) · Glia · doi:10.1002/glia.20207 · Cited by 1,611 · see citing works
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
Rothstein, J. D., Patel, S., Regan, M. R., Haenggeli, C., Huang, Y. H., Bergles, D. E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D. S., et al. (2005) · Nature · doi:10.1038/nature03180 · Cited by 1,518 · see citing works
Self-citationSelective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis
Rothstein, J. D., Van Kammen, M., Levey, A. I., Martin, L. J., & Kuncl, R. W. (1995) · Annals of Neurology · doi:10.1002/ana.410380114 · Cited by 1,471 · see citing works
Self-citationWong, P. C., Pardo, C. A., Borchelt, D., Lee, M. K., Copeland, N. G., Jenkins, N. A., Sisodia, S. S., Cleveland, D. W., & Price, D. L. (1995) · Neuron · doi:10.1016/0896-6273(95)90259-7 · Cited by 1,439 · see citing works
UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS
Bruijn, L. I., Miller, T. M., & Cleveland, D. W. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144244 · Cited by 1,371 · see citing works
Bruijn, L. I., Becher, M. W., Lee, M. K., Anderson, K. L., Jenkins, N. A., Copeland, N. G., Sisodia, S. S., Rothstein, J. D., Borchelt, D. R., Price, D. L., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80272-x · Cited by 1,341 · see citing works
Self-citationAstrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Nagai, M., Re, D. B., Nagata, T., Chalazonitis, A., Jessell, T. M., Wichterle, H., & Przedborski, S. (2007) · Nature Neuroscience · doi:10.1038/nn1876 · Cited by 1,220 · see citing works
Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis
Rothstein, J. D., Martin, L. J., & Kuncl, R. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199205283262204 · Cited by 1,180 · see citing works
Self-citationAstrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
Yamanaka, K., Chun, S. J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D. H., Takahashi, R., Misawa, H., & Cleveland, D. W. (2008) · Nature Neuroscience · doi:10.1038/nn2047 · Cited by 1,140 · see citing works
Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice
Clement, A. M., Nguyen, M. D., Roberts, E. A., Garcia, M. L., Boillée, S., Rule, M., McMahon, A. P., Doucette, W. T., Siwek, D. F., Ferrante, R. J., et al. (2003) · Science · doi:10.1126/science.1086071 · Cited by 1,101 · see citing works
Howland, D., Liu, J., She, Y., Goad, B., Maragakis, N. J., Kim, B. B., Erickson, J., Kulik, J., DeVito, L., Psaltis, G. C., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032539299 · Cited by 841 · see citing works
Self-citationMechanisms of Disease: astrocytes in neurodegenerative disease
Maragakis, N., & Rothstein, J. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0355 · Cited by 834 · see citing works
Self-citationNon–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model
Di Giorgio, F. P., Carrasco, M. A., Siao, M. C., Maniatis, T., & Eggan, K. (2007) · Nature Neuroscience · doi:10.1038/nn1885 · Cited by 799 · see citing works
Reactive Astrocytes in Neural Repair and Protection
Sofroniew, M. V. (2005) · The Neuroscientist · doi:10.1177/1073858405278321 · Cited by 742 · see citing works
Pramatarova, A., Laganière, J., Roussel, J., Brisebois, K., & Rouleau, G. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03369.2001 · Cited by 482 · see citing works
Aebischer, P., Schluep, M., Déglon, N., Joseph, J., Hirt, L., Heyd, B., Goddard, M. B., Hammang, J. P., Zurn, A. D., Kato, A. C., et al. (1996) · Nature Medicine · doi:10.1038/nm0696-696 · Cited by 446 · see citing works
Lino, M. M., Schneider, C., & Caroni, P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-12-04825.2002 · Cited by 424 · see citing works
Glutamate transporters: animal models to neurologic disease
Maragakis, N. J., & Rothstein, J. D. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.007 · Cited by 352 · see citing works
Self-citationA tripotential glial precursor cell is present in the developing spinal cord
Rao, M. S., Noble, M. A., & Mayer-Pröschel, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3996 · Cited by 312 · see citing works
Self-citationSuzuki, M., McHugh, J., Tork, C. A., Shelley, B., Klein, S. M., Aebischer, P., & Svendsen, C. N. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000689 · Cited by 311 · see citing works
Garbuzova-Davis, S. N., Willing, A. E., Zigova, T., Saporta, S., Justen, E. B., Lane, J. C., Hudson, J. E., Chen, N., Davis, C. D., & Sanberg, P. R. (2003) · Stem Cells and Development · doi:10.1089/152581603322022990 · Cited by 308 · see citing works
Glial-Restricted Precursors Are Derived from Multipotent Neuroepithelial Stem Cells
Rao, M. S. R., & Mayer‐Pröschel, M. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8597 · Cited by 286 · see citing works
Self-citationRecovery from paralysis in adult rats using embryonic stem cells
Deshpande, D. M., Kim, Y., Martinez, T. L., Carmen, J., Dike, S., Shats, I., Rubin, L. L., Drummond, J., Krishnan, C., Höke, A., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20901 · Cited by 271 · see citing works
Self-citationGDNF Delivery Using Human Neural Progenitor Cells in a Rat Model of ALS
Klein, S. M., Behrstock, S. P., McHugh, J., Hoffmann, K., Wallace, K., Suzuki, M., Aebischer, P., & Svendsen, C. N. (2005) · Human Gene Therapy · doi:10.1089/hum.2005.16.509 · Cited by 265 · see citing works
Human Neural Stem Cell Grafts Ameliorate Motor Neuron Disease in SOD-1 Transgenic Rats
Xu, L., Yan, J., Chen, D., Welsh, A. M., Hazel, T. G., Johe, K. K., Hatfield, G. S., & Koliatsos, V. E. (2006) · Transplantation · doi:10.1097/01.tp.0000235532.00920.7a · Cited by 258 · see citing works
Kerr, D. A., Lladó, J., Shamblott, M. J., Maragakis, N. J., Irani, D. N., Crawford, T. O., Krishnan, C., Dike, S., Gearhart, J. D., & Rothstein, J. D. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05131.2003 · Cited by 251 · see citing works
Self-citationHarper, J. M., Krishnan, C., Darman, J., Deshpande, D. M., Peck, S., Shats, I., Backovic, S., Rothstein, J. D., & Kerr, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401103101 · Cited by 234 · see citing works
Self-citationWu, P., Tarasenko, Y. I., Gu, Y., Huang, L.-Y. M., Coggeshall, R. E., & Yu, Y. (2002) · Nature Neuroscience · doi:10.1038/nn974 · Cited by 221 · see citing works
Kiaei, M., KIPIANI, K., CHEN, J., Calingasan, N. Y., & Beal, M. F. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.10.007 · Cited by 215 · see citing works
Lladó, J., Haenggeli, C., Maragakis, N. J., Snyder, E. Y., & Rothstein, J. D. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.07.010 · Cited by 208 · see citing works
Self-citationCorti, S. P., Locatelli, F., Donadoni, C., Guglieri, M., Papadimitriou, D. A., Strazzer, S., Bo, R. D., & Comi, G. P. (2004) · Brain · doi:10.1093/brain/awh273 · Cited by 195 · see citing works
Corti, S. P., Locatelli, F., Papadimitriou, D. A., Bo, R. D., Nizzardo, M., Nardini, M., Donadoni, C., Salani, S., Fortunato, F., Strazzer, S., et al. (2007) · Brain · doi:10.1093/brain/awm043 · Cited by 137 · see citing works
Yan, J., Xu, L., Welsh, A. M., Chen, D., Hazel, T. G., Johe, K. K., & Koliatsos, V. E. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0518 · Cited by 133 · see citing works
Mitsui, T., Fischer, I., Shumsky, J. S., & Murray, M. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.02.022 · Cited by 111 · see citing works
Pochon, N. A.-M., Heyd, B., Déglon, N., et al. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.7-851 · Cited by 110 · see citing works
Garbuzova-Davis, S. N., Willing, A. E., Milliken, M., Saporta, S., Žigová, T., Cahill, D. W., & Sanberg, P. R. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7860 · Cited by 100 · see citing works
Disease progression of human SOD1 (G93A) transgenic ALS model rats
Matsumoto, A., Okada, Y., Nakamichi, M., Nakamura, M., Toyama, Y., Sobue, G., Nagai, M., Aoki, M., Itoyama, Y., & Okano, H. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20708 · Cited by 88 · see citing works
Degeneration of respiratory motor neurons in the SOD1 G93A transgenic rat model of ALS
Lladó, J., Haenggeli, C., Pardo, A. C., Wong, V., Benson, L. M., Coccia, C., Rothstein, J. D., Shefner, J. M., & Maragakis, N. J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.06.019 · Cited by 71 · see citing works
Self-citationRespiratory impairment in a mouse model of amyotrophic lateral sclerosis
Tankersley, C. G., Haenggeli, C., & Rothstein, J. D. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00193.2006 · Cited by 66 · see citing works
Self-citationGene‐based treatment of motor neuron diseases
Federici, T., & Boulis, N. M. (2005) · Muscle & Nerve · doi:10.1002/mus.20439 · Cited by 64 · see citing works
Hemendinger, R. A., Wang, J., Malik, S. Z., Persinski, R., Copeland, J., Emerich, D. F., Gores, P. F., Halberstadt, C. R., & Rosenfeld, J. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.07.025 · Cited by 60 · see citing works
Maragakis, N. J., Rao, M. S., Lladó, J., Wong, V., Xue, H., Pardo, A. C., Herring, J., Kerr, D. A., Coccia, C., & Rothstein, J. D. (2005) · Glia · doi:10.1002/glia.20161 · Cited by 46 · see citing works
Self-citationMartin, L. J., & Liu, Z. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318158822b · Cited by 42 · see citing works
Intraspinal implantation of hNT neurons into SOD1 mice with apparent motor deficit
Garbuzova-Davis, S. N., Willing, A. E., Milliken, M., et al. (2001) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/14660820152882179 · Cited by 30 · see citing works
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Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · see citing works
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Haidet-Phillips, A. M., Hester, M. E., Miranda, C. J., Meyer, K., Braun, L., Frakes, A., Song, S., Likhite, S., Murtha, M. J., Foust, K. D., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1957 · Cited by 782 · see citing works
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Phatnani, H., & Maniatis, T. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020628 · Cited by 420 · see citing works
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Li, K., Li, J., Zheng, J., & Qin, S. (2019) · Aging and disease · doi:10.14336/ad.2018.0720 · Cited by 398 · see citing works
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Bi, F., Huang, C., Tong, J., Qiu, G., Huang, B., Wu, Q., Li, F., Xu, Z., Bowser, R., Xia, X.-G., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218497110 · Cited by 371 · see citing works
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“In addition, transplantation of wild-type astrocytes into SOD1 rat spinal cords was neuroprotective [348], and limited overexpression of NRF2 in astrocytes mitigated neurodegeneration in SOD1 and SOD1 mice [340].”
BackgroundDe Feo, D., Merlini, A., Laterza, C., & Martino, G. (2012) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328352ec45 · Cited by 181 · see citing works
Humphrey, J., Venkatesh, S., Hasan, R., Herb, J. T., de Paiva Lopes, K., Küçükali, F., Byrska-Bishop, M., Evani, U. S., Narzisi, G., Fagegaltier, D., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-022-01205-3 · Cited by 138 · see citing works
Tripathi, P., Rodriguez-Muela, N., Klim, J. R., de Boer, A. S., Agrawal, S., Sandoe, J., Lopes, C. S., Ogliari, K. S., Williams, L. A., Shear, M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.06.008 · Cited by 123 · see citing works
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- Authors
- Lepore, A. C., Rauck, B., Dejea, C., Pardo, A. C., Rao, M. S., Rothstein, J. D., & Maragakis, N. J.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Maragakis, Nicholas J
- Venue
- Nature Neuroscience
- Published
- 2008-10-19
- Volume
- 11
- Issue
- 11
- Pages
- 1294-1301
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC2656686
- OpenAlex
- W2121396070
- Cited by
- 441
- References
- 51
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 16 · 2023: 34 · 2022: 22 · 2021: 25 · 2020: 23 · 2019: 19 · 2018: 22 · 2017: 15 · 2016: 20 · 2015: 28 · 2014: 34 · 2013: 21 · 2012: 39
- FWCI
- 22.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01 NS41680, R01NS041680, R01-NS33958, F32NS059155, R01NS033958)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
- Keywords
- amyotrophic lateral sclerosis, astrocyte transplantation, SOD1 G93A, superoxide dismutase 1, neuroprotection, motor neuron degeneration, microglial activation, cervical spinal cord, respiratory motor neurons, astrocyte dysfunction
- MeSH terms
- Action Potentials, Animals, Astrocytes, Calcium-Binding Proteins, Cell Differentiation, Cell Movement, Cell Survival, Disease Models, Animal, Glial Fibrillary Acidic Protein, Hindlimb, Humans, Microfilament Proteins, Neural Conduction, Phrenic Nerve, Spinal Cord, Stem Cells, Superoxide Dismutase, Motor Neuron Disease, Cell Transplantation, Muscle, Skeletal, Excitatory Amino Acid Transporter 2, Animals, Genetically Modified, Green Fluorescent Proteins, Rats
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