The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis
Abstract
Objective: Enhanced lipid peroxidation is well established in traumatic brain injury. However, its molecular targets, identity of peroxidized phospholipid species, and their signaling role have not been deciphered. Methods: Using controlled cortical impact as a model of traumatic brain injury, we employed a newly developed oxidative lipidomics approach to qualitatively and quantitatively characterize the lipid peroxidation response. Results: Electrospray ionization and matrix‐assisted laser desorption/ionization mass spectrometry analysis of rat cortical mitochondrial/synaptosomal fractions demonstrated the presence of highly oxidizable molecular species containing C 22:6 fatty acid residues in all major classes of phospholipids. However, the pattern of phospholipid oxidation at 3 hours after injury displayed a nonrandom character independent of abundance of oxidizable species and included only one mitochondria‐specific phospholipid, cardiolipin (CL). This selective CL peroxidation was followed at 24 hours by peroxidation of other phospholipids, most prominently phosphatidylserine, but also phosphatidylcholine and phosphatidylethanolamine. CL oxidation preceded appearance of biomarkers of apoptosis (caspase‐3 activation, terminal deoxynucleotidyltransferase–mediated dUTP nick end labeling–positivity) and oxidative stress (loss of glutathione and ascorbate). Interpretation: The temporal sequence combined with the recently demonstrated role of CL hydroperoxides (CL‐OOH) in in vitro models of apoptosis suggest that CL‐OOH may be both a key in vivo trigger of apoptotic cell death and a therapeutic target in experimental traumatic brain injury. Ann Neurol 2007
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Self-citation[16] Isolation of subcellular organelles
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Cytochrome c/cardiolipin relations in mitochondria: a kiss of death
Kagan, V. E., Bayır, H. A., Belikova, N. A., Kapralov, O., Tyurina, Y. Y., Tyurin, V. A., Jiang, J., Stoyanovsky, D. A., Wipf, P., Kochanek, P. M., et al. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.03.004 · Cited by 444
Self-citationLipid analysis by thin-layer chromatography—A review of the current state
Fuchs, B., Süß, R., Teuber, K., Eibisch, M., & Schiller, J. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.11.066 · Cited by 377
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Metadata
- Authors
- Bayir, H., Tyurin, V. A., Tyurina, Y. Y., Viner, R., Ritov, V., Amoscato, A. A., Zhao, Q., Zhang, X. J., Janesko‐Feldman, K. L., Alexander, H., Basova, L. V., Clark, R. S. B., Kochanek, P. M., & Kagan, V. E.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2007-08
- Volume
- 62
- Issue
- 2
- Pages
- 154-169
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2010130396
- Cited by
- 190
- References
- 8
- FWCI
- 8.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bayir, H., Tyurin, V. A., Tyurina, Y. Y., Viner, R., Ritov, V., Amoscato, A. A., Zhao, Q., Zhang, X. J., Janesko‐Feldman, K. L., Alexander, H., Basova, L. V., Clark, R. S. B., Kochanek, P. M., & Kagan, V. E. (2007). Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis. Annals of Neurology. https://doi.org/10.1002/ana.21168
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