The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Stimulation of the subthalamic nucleus and impulsivity: Release your horses
Open accessAbstract
Objective: In Parkinson disease (PD) patients, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may contribute to certain impulsive behavior during high‐conflict decisions. A neurocomputational model of the basal ganglia has recently been proposed that suggests this behavioral aspect may be related to the role played by the STN in relaying a “hold your horses” signal intended to allow more time to settle on the best option. The aim of the present study was 2‐fold: 1) to extend these observations by providing evidence that the STN may influence and prevent the execution of any response even during low‐conflict decisions; and 2) to identify the neural correlates of this effect. Methods: We measured regional cerebral blood flow during a Go/NoGo and a control (Go) task to study the motor improvement and response inhibition deficits associated with STN‐DBS in patients with PD. Results: Although it improved Unified Parkinson Disease Rating Scale motor ratings and induced a global decrease in reaction time during task performance, STN‐DBS impaired response inhibition, as revealed by an increase in commission errors in NoGo trials. These behavioral effects were accompanied by changes in synaptic activity consisting of a reduced activation in the cortical networks responsible for reactive and proactive response inhibition. Interpretation: The present results suggest that although it improves motor functions in PD patients, modulation of STN hyperactivity with DBS may tend at the same time to favor the appearance of impulsive behavior by acting on the gating mechanism involved in response initiation. Ann Neurol 2009;66:817–824
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“This hypothesis is consistent with the observed deactivation of the precuneus/PCC node, which plays a pivotal role within the default network, acting as a convergence node where cognitive information arising from different subsystems interact.(37) Thus a deactivation of this node would have a significant detrimental e…”
ResultDetecting activations in PET and fMRI: levels of inference and power
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“001 uncorrected at the voxel level, and a restricted volume analysis was used to test specific a priori hypotheses.(21,22) This analysis considered all voxels within a mask image that included regions of interest (ROIs).”
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Cited by
Inhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921
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Neurophysiology of performance monitoring and adaptive behavior
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A fronto–striato–subthalamic–pallidal network for goal-directed and habitual inhibition
Jahanshahi, M., Obeso, I., Rothwell, J. C., & Obeso, J. A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4038 · Cited by 521
Criaud, M., & Boulinguez, P. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.11.003 · Cited by 368
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Metadata
- Authors
- Ballanger, B., van Eimeren, T., Moro, E., Lozano, A. M., Hamani, C., Boulinguez, P., Pellecchia, G., Houle, S., Poon, Y. Y., Lang, A. E., & Strafella, A. P.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2009-12
- Volume
- 66
- Issue
- 6
- Pages
- 817-824
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2096435819
- Cited by
- 264
- References
- 13
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- green
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