A fronto–striato–subthalamic–pallidal network for goal-directed and habitual inhibition

Jahanshahi, Marjan; Obeso, Ignacio; Rothwell, John C.; Obeso, José A.

doi:10.1038/nrn4038

Cited by 521Neurological disorders and treatmentsNeural and Behavioral Psychology StudiesObsessive-Compulsive Spectrum Disorders

A fronto–striato–subthalamic–pallidal network for goal-directed and habitual inhibition

Jahanshahi, Marjan, Obeso, Ignacio, Rothwell, John C., Obeso, José A.·2015·Nature Reviews Neuroscience

DOI 10.1038/nrn4038

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Abstract

Classically, the basal ganglia have been considered to have a role in producing habitual and goal-directed behaviours. In this article, we review recent evidence that expands this role, indicating that the basal ganglia are also involved in neural and behavioural inhibition in the motor and non-motor domains. We then distinguish between goal-directed and habitual (also known as automatic) inhibition mediated by fronto-striato-subthalamic-pallido-thalamo-cortical networks. We also suggest that imbalance between goal-directed and habitual action and inhibition contributes to some manifestations of Parkinson's disease, Tourette syndrome and obsessive-compulsive disorder. Finally, we propose that basal ganglia surgery improves these disorders by restoring a functional balance between facilitation and inhibition.

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Converging lines of evidence have implicated these fronto-striatal circuits in the pathophysiology of OCD.
“which converging lines of evidence have implicated in the pathophysiology of OCD (Burguière et al., 2015, Jahanshahi et al., 2015, Pauls et al., 2014).”
From Inhibitory control in obsessive compulsive disorder: a systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies (2022) · cites this paper as Jahanshahi et al., 2015

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Authors: Jahanshahi, M., Obeso, I., Rothwell, J. C., & Obeso, J. A.
Affiliations: National Hospital for Neurology and Neurosurgery (GB)
Universidad San Pablo CEU (ES)
Corresponding author: Jahanshahi, Marjan
ORCID: Jahanshahi, Marjan
Obeso, Ignacio
Rothwell, John C.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2015-11-04
Volume: 16
Issue: 12
Pages: 719-732
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn4038
OpenAlex: W2256669593
Cited by: 521
References: 194
Citations by year: 2026: 39 · 2025: 36 · 2024: 38 · 2023: 35 · 2022: 58 · 2021: 52 · 2020: 66 · 2019: 63 · 2018: 64 · 2017: 52 · 2016: 16
FWCI: 5.79
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Keywords: basal ganglia, cortico-basal ganglia circuits, Parkinson's disease, Tourette syndrome, obsessive-compulsive disorder, basal ganglia surgery, motor inhibition
MeSH terms: Animals, Brain, Goals, Habituation, Psychophysiologic, Humans, Inhibition, Psychological, Nerve Net, Neural Pathways

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A fronto–striato–subthalamic–pallidal network for goal-directed and habitual inhibition

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