The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis
Open accessAbstract
Objective: Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motor neurons, of unknown etiology. Previous studies showed reverse transcriptase in serum of ALS patients at levels comparable to human immunodeficiency virus‐infected patients; however, the source and significance of the retroviral elements is uncertain. Methods: Expression of a human endogenous retrovirus (HERV‐K) was determined in autopsy brain tissue of patients with ALS and compared to control populations by real‐time polymerase chain reaction followed by sequencing of the amplified genes and confirmed by immunostaining. Results: HERV‐K pol transcripts were increased in patients with ALS compared to those with chronic systemic illness, but could not be detected in Parkinson disease or in the accidental death controls. Sequencing revealed several actively transcribed loci in the HML‐2 and 3 subfamilies of HERV‐K, with a specific pattern of expression including intact open reading frames and the transcription of a unique locus in ALS. The frequency of intact pol transcripts was highest in the motor cortex, and the reverse transcriptase protein was localized to cortical neurons of ALS patients. HERV‐K expression strongly correlated with TDP‐43, a multifunctional protein known to be dysregulated in ALS. Interpretation: We have identified a specific pattern of HERV‐K expression in ALS, which may potentially define the pathophysiology of ALS. Targeting of activated genome‐encoded retroviral elements may open new prospects for the treatment of ALS. Ann Neurol 2011;69:141–151.
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CDD: specific functional annotation with the Conserved Domain Database
Marchler-Bauer, A., Anderson, J. B., Chitsaz, F., Derbyshire, M. K., DeWeese-Scott, C., Fong, J. H., Geer, L. Y., Geer, R. C., Gonzales, N. R., Gwadz, M., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn845 · Cited by 1,071
Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition
Muotri, A. R., Chu, V. T., Marchetto, M. C. N., Deng, W., Moran, J. V., & Gage, F. H. (2005) · Nature · doi:10.1038/nature03663 · Cited by 942
Ou, S. H., Wu, F., Harrich, D., García-Martínez, L. F., & Gaynor, R. B. (1995) · Journal of Virology · doi:10.1128/jvi.69.6.3584-3596.1995 · Cited by 758
Are amyotrophic lateral sclerosis patients cognitively normal?
Lomen-Hoerth, C., Murphy, J., Langmore, S., Kramer, J. H., Olney, R. K., & Miller, B. (2003) · Neurology · doi:10.1212/01.wnl.0000055861.95202.8d · Cited by 620
Intrinsic immunity: a front-line defense against viral attack
Bieniasz, P. D. (2004) · Nature Immunology · doi:10.1038/ni1125 · Cited by 454
The Evolutionary Dynamics of Human Endogenous Retroviral Families
Bannert, N., & Kurth, R. (2006) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115700 · Cited by 371
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
van Es, M. A., van Vught, P. W., Blauw, H. M., Franke, L., Saris, C. G., Van Den Bosch, L., de Jong, S. W., de Jong, V., Baas, F., van't Slot, R., et al. (2008) · Nature Genetics · doi:10.1038/ng.2007.52 · Cited by 214
Johnston, J. B., Silva, C., Holden, J., Warren, K. G., Clark, A. W., & Power, C. (2001) · Annals of Neurology · doi:10.1002/ana.1131 · Cited by 207
Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases
Geser, F., Martinez-Lage, M., Kwong, L. K., Lee, V. M.-Y., & Trojanowski, J. Q. (2009) · Journal of Neurology · doi:10.1007/s00415-009-5069-7 · Cited by 194
Identification of endogenous retroviral reading frames in the human genome
Villesen, P., Aagaard, L., Wiuf, C., & Pedersen, F. S. (2004) · Retrovirology · doi:10.1186/1742-4690-1-32 · Cited by 186
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Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
Ferraiuolo, L., Kirby, J., Grierson, A. J., Sendtner, M., & Shaw, P. J. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.152 · Cited by 615
Human endogenous retrovirus-K contributes to motor neuron disease
Li, W., Lee, M.-H., Henderson, L., Tyagi, R., Bachani, M., Steiner, J., Campanac, E., Hoffman, D. A., von Geldern, G., Johnson, K., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac8201 · Cited by 482
Self-citationRestricting retrotransposons: a review
Goodier, J. L. (2016) · Mobile DNA · doi:10.1186/s13100-016-0070-z · Cited by 436
Risk factors for amyotrophic lateral sclerosis
Fang, F., Ingre, C., Roos, P., Kamel, F., & Piehl, F. (2015) · Clinical Epidemiology · doi:10.2147/clep.s37505 · Cited by 462
Resurrection of endogenous retroviruses during aging reinforces senescence
Liu, X., Liu, Z., Wu, Z., Ren, J., Fan, Y., Sun, L., Cao, G., Niu, Y., Zhang, B., Ji, Q., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.017 · Cited by 390
Metadata
- Authors
- Douville, R., Liu, J., Rothstein, J., & Nath, A.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2011-01
- Volume
- 69
- Issue
- 1
- Pages
- 141-151
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2116710635
- Cited by
- 317
- References
- 38
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- green
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